The impact of hypogammagammaglobulinemia on infection outcome in patients undergoing ventricular assist device implantation.
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Agammaglobulinemia↗
Biomedical subjects
S Hacker
Publications and source records attributed to S Hacker.
Recovery from giant cell myocarditis with ECMO support and utilisation of polyclonal antithymocyte globulin: a case report.
Giant cell myocarditis (GCM) is a rare and frequently fatal disorder. Patients suffer of ventricular arrhythmias or congestive heart failure. Here we describe a patient with cardiogenic shock and histological verified GCM. The patient was saved by implantation of extracorporeal membrane oxygeneation (ECMO) device and concomitant application of Rabbit antithymocyte globuline (rATG, Thymoglobulin, Sangstat), cyclosporine, and steroids in the acute event. 12 months after the crisis the patient evidences NYHA class I heart function and only a moderate impairment of heart function (EF 55%). The novel utilisation of ECMO in GCM related cardiogenic shock and application of rATG have prooven life-saving in this patient. Studies utilizing rATG in the treatment of GCM are warrented.
Antilymphocyte Serum↗
EUS Meets Voxel-Man: three-dimensional anatomic animation of linear-array endoscopic ultrasound images.
Endoscopic ultrasonography (EUS) is a widely used imaging modality in gastroenterology. The development of linear-array endoscopic ultrasound transducers, with facilities for EUS-guided diagnostic and therapeutic procedures, led to increasingly widespread use in different areas of the body. Examiners need to have excellent knowledge of anatomy. Orientation in linear EUS is more difficult and the learning curve is long. In an effort to shorten the training, reducing the risk to the patient and to allow a faster learning of the basic anatomic structures EUS meets VOXEL-MAN, an interactive three-dimensional anatomic simulation program has been developed for linear EUS for the purposes of private and independent study.
Anatomy, Artistic↗
Smoking, dietary, and breast and cervical cancer screening knowledge and screening practices of employees in an urban medical center.
This paper reports results of a survey of 500 health care workers in a private New York City Hospital that assessed knowledge and behaviors in the areas of smoking and cancer, diet and cancer, and breast and cervical cancer screening. Given the small number of knowledge items, the results indicated good knowledge concerning diet and cancer, smoking and cancer, and mammography and Pap test guidelines. Conformity with American Cancer Society guidelines for Pap testing was comparable to national figures, but with women over 50 as likely to obtain Pap smears as younger women. Conformity with mammography guidelines was excellent, although compliance with breast self-examination recommendations was low (25.4%). Of female employees over age 50, 87.4% had ever had mammography and 77.6% reported yearly mammography. Only 19% of the respondents admitted to current smoking. Although methodologic differences made comparison of knowledge of diet and cancer with the work of others difficult, knowledge of the risks of smoking was comparable to levels found in other studies.
Adult↗
[Early vectorcardiographic diagnosis of rejection in long-term follow-up of heart transplantation].
A series of 194 transplant subjects was followed-up by over 2,600 vectorcardiograms. Several cases of rejection were chosen among the most patent and best documented cases (eight cases of acute rejection and seven cases of chronic rejection) and 15 control cases where all tests, including the vectorcardiogram, had always remained negative. Two criteria of rejection were used, i.e. the amplitude of the left maximum QRS vector less than 1.10 mV and relative right spatial area greater than 35 per cent. By accumulating all traces for each patient, recorded during and outside the rejection phase, it was found that the mean of the individual means was 0.96 mV for the left amplitude in cases of rejection versus 1.74 mV in the control group, and 44 versus 22 per cent for the right area. The first trace which, on the curves showing the progress of each patient, was likely to signal acute or chronic rejection always had a left amplitude less than 1 mV (mean 0.89 mV) and a right area greater than 33 per cent (mean 45%). The first suspicious trace always preceded the detection of signs by echography or biopsy (except in one case where it occurred at the same time). The interval varied from 16 to 112 days in five cases of rejection assessed as acute, and from 63 to 600 days in seven cases of chronic rejection. There was no echographic control in two other cases, but death occurred 45 and 63 days after the first vectorcardiographic signs. The vectorcardiogram improves after recovery from acute rejection.(ABSTRACT TRUNCATED AT 250 WORDS)
Follow-Up Studies↗
Independent regulation of beta 1- and beta 2-adrenoceptors.
1 The down-regulation of beta-adrenoceptors has been postulated as a biochemical marker of antidepressant efficacy. Here we demonstrate that chronic treatment with desipramine down-regulates beta 1-adrenoceptors in rat cerebral cortex and that beta-adrenoceptor subtypes can be independently regulated by treatment with different beta-adrenoceptor agonists. 2 Desipramine, (+/-)-clenbuterol, prenalterol, corwin (20 mg kg-1 daily) and corwin (10 mg kg-1 daily) were administered to male, Sprague-Dawley rats, over eight days, by means of osmotic Alzet pumps placed subcutaneously and removed 24 h before analysis. Control rats received vehicle only. The beta 1- and beta 2-adrenoceptor populations were measured in cerebral cortex by a modified (-)-[125I]-pindolol receptor binding assay. 3 The conventional antidepressant, desipramine, preferentially down-regulated beta 1-adrenoceptors whereas the non-selective beta-adrenoceptor agonist (+/-)-clenbuterol preferentially down-regulated beta 2-adrenoceptors. The beta 1-selective partial agonist, prenalterol, up-regulated beta 1-adrenoceptors perhaps acting more as an antagonist than as an agonist. Finally, neither dose of corwin had any significant effect on beta-adrenoceptor number.
Adrenergic beta-Agonists↗
Obstacles in coordinating services for the care of the psychiatrically ill aged.
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Age Factors↗