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Biomedical subjects

S Hague

Publications and source records attributed to S Hague.

13 recordsLinked to original sources
PubMed1998

PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium.

Tamoxifen is currently the most widely used drug for the treatment of breast cancer, but there now exists considerable evidence that tamoxifen can also induce endometrial hyperplasia in pre menopausal women. We have used PCR differential display on primary human endometrial isolates in an attempt to identify genes induced by tamoxifen but not estrogen. Eight such differentially expressed bands were cloned and sequenced, one of which was found to be the peptide adrenomedullin. We have shown that adrenomedullin is a novel growth factor for endothelial cells and is angiogenic in vivo in the chick chorioallantoic membrane assay. Immunohistochemical analysis of endometrial sections have shown that while macrophages in the endometrium express adrenomedullin at a low level, endometrial macrophages of women receiving tamoxifen strongly express adrenomedullin (P=0.008). We postulate that endometrial induction of the angiogenic factor adrenomedullin by tamoxifen is part of the mechanism by which tamoxifen results in endometrial hyperplasia.

Adrenomedullin↗
PubMed1998

Multifocal choroiditis: clinicopathologic correlation.

Many of the white dot syndromes are considered to have a granulomatous pathogenesis. The histopathologic characteristics of this case of multifocal choroiditis seen within 15 months of apparent clinical onset show that the white dot lesions were nongranulomatous perivascular choroidal infiltrates, consisting mainly of B lymphocytes. Early choroidal neovascularization was also seen.

Adult↗
PubMed1997

Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome.

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 10% of women of reproductive age. Women with anovulatory PCOS have hyperinsulinaemia, insulin resistance, and dyslipidaemia, and the syndrome is associated with greatly increased risks of non-insulin-dependent diabetes mellitus and cardiovascular disease and it often clusters in families. The VNTR (variable number of tandem repeats) locus upstream of the insulin gene (INS) regulates insulin expression. We have studied INS VNTR as a candidate genetic locus for susceptibility to PCOS. METHODS: We evaluated linkage of PCOS to the INS VNTR locus on chromosome 11p15.5 in 17 families with several cases, and looked for an association between VNTR and PCOS in two additional clinic populations. VNTR genotypes were designated I/I, I/III, and III/III and linkage disequilibrium mapping was used to test the primary role of the VNTR. FINDINGS: In a group of PCOS/male pattern baldness families, we obtained positive evidence for linkage to 11p15.5 (p = 0.002). The INS VNTR III/III genotype was associated with an increased risk of PCOS in two independent case-control studies (odds ratios 8.20 [p = 0.005] and 5.70 [p = 0.043]). Multilocus linkage disequilibrium mapping suggests that VNTR itself is the predisposing locus. INTERPRETATION: Mapping of susceptibility to PCOS to the INS VNTR implies that PCOS is due, in part, to an inherited alteration in insulin production. The data suggest a mechanistic link between type 2 diabetes and PCOS, which is a risk factor for diabetes later in life.

Alleles↗
PubMed1997

Motion detection deficits in infantile esotropia without nystagmus.

PURPOSE: To investigate whether adults with infantile strabismus but without latent nystagmus have abnormalities of horizontal motion detection. METHODS: Eleven adult subjects with infantile esotropia but without latent nystagmus and 15 control subjects were required to detect the onset of motion and drift direction of a sinusoidal, spatial frequency grating that moved with linearly increasing velocity. The grating was presented monocularly in paracentral vision at an eccentricity of 16.5 degrees with a field size of 18 degrees. The contrast of the grating was just above contrast threshold for visibility. RESULTS: The mean velocity threshold for detection of motion was raised significantly in the patient group compared with the control group. Nine of the 11 subjects with infantile esotropia demonstrated directional asymmetry for the detection of motion. Thresholds were elevated more often when the grating was moving nasally in the squinting eye and temporally in the nonsquinting eye, and raised thresholds were more prevalent in the squinting eye. CONCLUSIONS: The findings indicate that in infantile esotropia, the presence of motion perception deficits are not always associated with the development of latent nystagmus. The predominance of nasally directed motion deficits in the squinting eye and temporally directed motion deficits in the nonsquinting eye was unexpected and may have been caused by abnormal development of cortical motion processing.

Adult↗
PubMed1994

Blepharoplasty and ptosis.

Recent advances in local anesthetic techniques have led to suggestions that buffered solutions for infiltration increase patient comfort. The use of an eutectic mixture of local anesthetics cream has however proved to be disappointing. The use of monopolar electrocautery, carbon dioxide lasers, and high-frequency radio wave electrosection provide the surgeon with new modes of cutting and coagulation. Lower lid blepharoplasty via a conjunctival approach may avoid many of the complications of the anterior approach. Such complications may also be minimized by careful preoperative planning and frequently the inclusion of a lateral canthopexy in the surgical procedure. The lid height after anterior and posterior levator resection can now be set more accurately with adjustable suture techniques. A new technique combining a superior tarsectomy with levator resection is described. A range of materials for brow suspension are now available. Autogenous fascia lata remains the material of choice when available.

Anesthesia, Local↗
PubMed1991

Collaborative research: benefits and guidelines.

Several benefits of collaborative research and guidelines for strengthening collaborative mechanisms have been described here, but the impetus for research and development of competent research teams must come from health professionals themselves. The literature makes it apparent that allied health professionals need to devote a considerable amount of energy and resources to develop a knowledge base for the health-related professions, similar to those in medicine and the biological sciences. Research projects, particularly collaborative ones, can make significant contributions to the body of professional knowledge, the knowledge-generation process, the health care practitioner, and the patient. The results of research should not be judged successful until its ultimate goal (ie, impact on patients and practice) has been measured. In collaborative research, relationships should be based on systems thinking, making networking into a scientific approach--a true partnership approach--which is crucial in dealing with the problems of health care today.

Allied Health Occupations↗
PubMed1989

Children presenting to an ophthalmic casualty department.

A five month prospective survey of all children (0-14 years) attending an ophthalmic accident and emergency department was carried out to determine the disease profile and the primary ophthalmic health care provided. A data base was used to collect and analyse all cases. Seventy three per cent of 475 children attending had non-traumatic ophthalmic diagnoses, less than half being referred from their general practitioners. The remaining children had minor ophthalmic injuries of which less than one quarter were referred from their general practitioners. Four of the minor ophthalmic injuries were suspected of being non-accidental injury. The management of such cases is discussed. The ophthalmologist in an ophthalmic casualty department has an important role in the provision of primary ophthalmic care for children. In the management of minor ophthalmic injuries, the alerting factors for non-accidental injury should be sought, although the apparent incidence is low.

Adolescent↗
PubMed1988

Ocular trauma.

Explore the source record for details and available documents.

Eye↗
PubMed1988

The calibre changes of retinal vessels subject to prolonged hyperoxia.

The constriction of retinal vessels occurring in response to breathing 100% oxygen was studied in 10 normal subjects over a period of 30 min. Brachial blood pressure, radial pulse and end tidal CO2 were recorded throughout. The mean arteriolar constriction was 15.3% +/- 4.6 and venous constriction 21.8% +/- 4.3. Time constants (the time for 95% of the maximal response to have occurred) were 2.25 min +/- 0.75 and 2.37 min +/- 0.57 for arterioles and veins respectively. A highly variable late vascular response was recorded. A small proportion of arterial vessels showing a response were nonuniform while a larger proportion of veins showed a significant dilatation.

Adult↗
PubMed1988

Ocular quinine toxicity.

A case of ocular quinine toxicity is described which showed the typical acute visual loss and subsequent recovery. Vermiform motion of the pupil was noted 48 hours after overdose. This acute effect has not been reported before. Although acute systemic intoxication may respond to removal of quinine from the gut and circulation, there is no evidence that any treatment affects the visual prognosis. The action of quinine on the retina is unknown. We suggest it may block cholinergic neurotransmission in the inner synaptic layer.

Adult↗
PubMed1988

Postural changes in perfusion pressure and retinal arteriolar calibre.

Ophthalmic artery perfusion pressures and retinal arteriolar calibres were studied in 10 human subjects when sitting, standing, and lying. Differing responses in perfusion pressure were found; autoregulatory responses were found in 13 of the 18 significant calibre changes on moving from sitting to standing and 13 of 22 significant calibre changes on moving from standing to lying. The remaining significant calibre changes were non-autoregulatory, the arterioles dilating with perfusion pressure increase and constricting with decrease.

Adult↗
PubMed1987

Morphological changes in the human corneal epithelium associated with surgical corneal clouding.

Light microscopy and electron microscopy were used to define morphological changes occurring in human corneal epithelium during surgery. No correlation was established between preoperative medication or peroperative fluids and corneal epithelial clouding. It is suggested that the changes we observed in relation to epithelial clouding were the direct result of disturbance to endothelial pump functions.

Cell Nucleus↗