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Biomedical subjects

S Hanley

Publications and source records attributed to S Hanley.

22 records · Page 2Linked to original sources
PubMed1985

Sciatic neuropathy secondary to migration of trochanteric wire following total hip arthroplasty.

Delayed sciatic neuropathy secondary to migration of a free segment of trochanteric wire in an otherwise successful total hip arthroplasty seems not to have been reported previously. A 60-year-old woman with a total hip arthroplasty with a lateral transtrochanteric approach had the trochanter reattached with two 18-gauge Vitallium wires. The osteotomy healed uneventfully despite a break in the vertical wire ten days after surgery. Five years and ten months later, the patient began to have severe sciatic pain. Roentgenograms showed a free fragment of trochanteric wire posterior to the hip joint. On exploration, the 2-cm wire fragment was found to lie entirely within the epineurium of the sciatic nerve.

Female↗
PubMed1984

Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.

We present the DNA sequence of a 914-base pair fragment from Saccharomyces cerevisiae that contains the GAL1-GAL10 divergent promoter, 140 base pairs of GAL10 coding sequence, and 87 base pairs of GAL1 coding sequence. From this fragment, we constructed four pairs of GAL1-lacZ and GAL10-lacZ fusions on various types of yeast plasmid vectors. On each type of vector, the fused genes were induced by galactose and repressed by glucose. The response of a GAL1-lacZ fusion to gal4 and gal80 regulatory mutations was similar to the response of intact chromosomal GAL1 and GAL10 genes. A set of deletions that removed various portions of the GAL10 regulatory sequences from a GAL10-CYC1-lacZ fusion was constructed in vitro. These deletions defined a relatively guanine-cytosine-rich region of 45 base pairs that contained sequences necessary for full-strength galactose induction and an adjacent guanine-cytosine rich 55 base pairs that contained sequences sufficient for weak induction.

Alleles↗
PubMed1983

Monoamine oxidase activity in diabetes.

Monoamine oxidase (MAO) activities were measured in platelets from insulin-dependent and non-insulin-dependent diabetic subjects and in platelets from nondiabetic controls. Circulating levels of glycosylated hemoglobin (HbA1) were determined simultaneously. Mean MAO activities were not significantly different in any of these groups. MAO activity did not relate to the age of the individual, but mean values for females were higher than mean values for males in healthy controls and in insulin-dependent diabetics. In this study mean HbA1 levels were higher in female than in male diabetics. There was no relationship between MAO activity and HbA, level when results for males and females were analyzed separately.

Adolescent↗