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Biomedical subjects

S Hartmann

Publications and source records attributed to S Hartmann.

85 records · Page 5Linked to original sources
PubMed1976

[Severe coagulopathy due to inhibitors of several clotting factors in IgM paraproteinaemia (author's transl)].

A 62-year-old man presented with an IgM paraproteinaemia and then suddenly developed an haemophilia-like haemorrhagic diathesis. Clotting tests revealed markedly prolonged Quick prothrombin times (more than 2 min) and much diminished factor II, V, VII, and X activities. Cross-mixing experiments indicated the presence of a circulating inhibitor, which specifically blocked the activity of these factors. But the exact mechanism remains uncertain, no inhibitor of this type having been previously reported. In addition to the clotting defect there was a probably monoclonal immunoglobulin IgM. Complete remission occurred and has now persisted for 18 months, after immuno-suppressive treatment with azathioprine and prednisone. It is suggested that the inhibitory capacity is confined to the abnormal IgM, due to a primary immunological disorder. A review of similar reported cases emphasizes the importance of immunosuppressive treatment in this disorder.

Azathioprine↗
PubMed1975

The influence of urea and guanidine chloride on the binding of the binding of the bacterial substrate and inhibitors to hen lysozyme at physiological temperature (40 degrees) (*).

The influence of urea and of guanidine chloride on the binding of the bacterial substrate and of inhibitors such as N-acetylglucosamine or chitotetraose to hen lysozyme were studied at 20 degrees and at 40 degrees C (physiological temperature). The action of urea did not prevent a certain degree of organization of the enzyme compatible with its usual behaviour in the presence of some inhibitors and with its crystallization ; guanidine chloride, already at low concentrations, seemed to have a more severe effect on lysozyme.

Acetylglucosamine↗
PubMedDate not supplied

[The model of the non-trivial machine or the semiotic alternative. Remarks to Th. v. Uexkülls and W. Weisiacks regarding the theoretical basis of human medicine].

The authors discuss the attempt by v. Uexküll and Wesiack to formulate the basics of human medicine within the framework of a sign theory. They criticize this attempt mainly in three points: 1. Central concepts of their model--i.e. "meaning", "sign" or "signcoupling"--are only used as general concepts and not in the differentiated manner they are conventionally used in semiotics. 2. Human behavior is reduced to conditioned reflex systems which are merely described in a different, semiotic way. 3. Problems evolving from the epistemology of a radical constructivism on which their model of a "bio-psycho-social medicine" is based, remain not only unsolved but also undiscussed.

Humans↗
PubMedDate not supplied

[Neonatal ultrasonographic cerebral findings: association with risk factor for cerebral palsy].

BACKGROUND: Is it possible to identify patients with cerebral palsy (CP) with postnatal ultrasound scan? Which risk factors are associated with an increased risk of CP?. PATIENTS AND METHODS: The data of 37 children with CP, who were sonographically investigated during the first 24 hours of life were analyzed retrospectively. The data of 21 preterm infants with gestational age </= 32 wk were compared with the data of 59 without CP. RESULTS: A tetraparesis was found in 15/21 of preterm babies </= 32 wk, a hemiparesis in 4/8 of premature infants >/= 33 wk and in 5/8 of the mature babies. The mature babies had prenatal brain atrophy or hypoxic-ischaemic cerebral lesions. Cytomegaly and encephalitis were detected in two babies. Immature babies >/= 33 wk showed prenatal porencephaly or encephalomalacia after asphyxia. Premature babies </= 32 wk had cystic periventricular leucomalacia (n=12) or cerebral haemorrhage (n=3); 3 babies had meningitis. Only two prematures </= 32 wk with mild CP had inconspicuous ultrasound scans. Factors associated with cerebral palsy were: cystic periventricular leucomalacia (OR 24,89; 95 % CI: 5,85 - 105,87), cerebral atrophy (OR 4,84; 95 % CI: 1,61 - 14,51), fetal hypoxia (CTG) - (OR 4,78; 95 % CI: 1,31 - 17,45), abruptio placentae (OR 4,32; 95 % CI: 1,16 - 16,13), anemia after birth (OR 18,13; 95 % CI: 1,97 - 166,43), abnormal neurological behavior at term (OR 14,00; 95 % CI: 3,29 - 59,55). CONCLUSION: Cerebral ultrasound scan after birth is a useful method detect for cerebral lesions in patients with CP-risks.

Abruptio Placentae↗
PubMedDate not supplied

Effects of age, gender and ear side on SOAE parameters in infancy and childhood.

We investigated 267 infants and children aged 9 days to 16.8 years to study the spontaneous otoacoustic emission (SOAE) data prevalence, number per ear, level and frequency as a function of growth. Dependence on age, gender and ear side was statistically analyzed using the method of generalized estimation equations. Except in the 1st year of life, SOAE prevalence per ear and SOAE number per ear decreased significantly with increasing age. Both SOAE parameters were significantly higher in female than in male subjects, with gender difference of SOAE prevalence per ear being more distinct in the 1st year of life. Although a clear ear side effect on SOAE prevalence per ear could already be seen in ears of female children in this age group, only SOAE number per ear was significantly higher in right ears than in left ears from the 1st year of life on. Except in the first 12 months, SOAE level and SOAE frequency decreased significantly with increasing age. Neither a significant gender difference nor a significant ear side difference could be determined. Our results found in infancy and childhood are discussed within the framework of the current literature.

Adolescent↗
PubMedDate not supplied

[Work site health promotion in Germany--1: Program availability and effect on occupational characteristics].

Worksite health promotion and disease prevention is becoming more and more established in Germany. This study investigates the state of the health programmes utilising a representative sample of 116 companies with company health insurance. 105 companies answered the detailed questions during phone interviews or using written questionnaires. 60% of the companies offer worksite health promotion and disease prevention programmes. The focus is mainly on behavioural aspects, while structural aspects play a minor role within the programmes. To a great extent the health promotion and disease prevention programmes are independent of structural characteristics of the company and the company location. At present, an evaluation of the health benefits and cost-effectiveness of the health programmes is only of secondary interest.

Forecasting↗