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Biomedical subjects

S Hartzman

Publications and source records attributed to S Hartzman.

9 recordsLinked to original sources
PubMed1995

Technetium-99m-sestamibi single agent localization versus high resolution ultrasonography for the preoperative localization of parathyroid glands in patients with primary hyperparathyroidism.

Technetium 99m sestamibi, a newer radionuclide agent, has shown promise in parathyroid scintigraphy. Recent studies using technetium 99m sestamibi in conjunction with subtraction iodine I123 imaging have demonstrated accuracy for localizing parathyroid glands in patients with hyperparathyroidism. The effectiveness of technetium 99m sestamibi scanning as a single agent was compared prospectively with conventional high resolution ultrasonography for the preoperative localization of abnormal parathyroid glands in patients with primary hyperparathyroidism. Seventeen patients with primary hyperparathyroidism had preoperative evaluation with high resolution ultrasonography and technetium 99m sestamibi radionuclide scanning. All patients underwent bilateral neck exploration. Ultrasound results were made available to the surgeon preoperatively; however, technetium 99m sestamibi results were withheld unless specifically asked for by the surgeon intraoperatively. Comparison of the imaging studies were correlated with the operative and histological findings. Of 17 patients, 12 had solitary adenomas and four had diffuse hyperplasia. In one patient no abnormal glands were discovered. In patients with technetium 99m sestamibi localization, a solitary adenoma was identified correctly in 10 of 12 patients (83%). Three of four patients with diffuse hyperplasia had parathyroid sestamibi scans showing nonfocal or diffuse uptake in multiple glands. High resolution ultrasonography correctly identified only six of 12 patients with solitary parathyroid adenomas (50%). Of the patients with diffuse hyperplasia, two ultrasound studies showed a single enlarged gland, one study was negative, and one localized two questionable, enlarged glands. Technetium 99m sestamibi is effective as a single agent for preoperative parathyroid scintigraphy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenoma↗
PubMed1989

Acute renal dysfunction in high-risk patients after angiography: comparison of ionic and nonionic contrast media.

A group of 145 high-risk patients who underwent angiography after administration of the nonionic contrast agent iohexol were monitored for the development of acute renal dysfunction. The results in this group were compared with those in 202 high-risk historical control subjects who had undergone angiography after administration of ionic contrast material. All patients in both groups received similar pre- and postangiographic treatment. A greater number of patients in the ionic group had preexisting renal disease, were of advanced age, and had received large volumes of contrast material. Acute renal dysfunction occurred in 20 of the 202 (10%) patients in the ionic group, compared with eight of the 145 (5.5%) patients in the nonionic group; this difference is not statistically significant. Five patients in the ionic group, but none of the patients in the nonionic group, ultimately required dialysis; this difference is not statistically significant. The findings suggest that a randomized trial in high-risk patients should be undertaken before a clinical advantage of the nonionic contrast agent iohexol with regard to renal function can be assumed.

Acute Kidney Injury↗
PubMed1989

Budd-Chiari syndrome: treatment with percutaneous transhepatic recanalization and dilation.

The authors describe a child with Budd-Chiari syndrome secondary to membranous obstruction of the hepatic veins and a web in the inferior vena cava. Transhepatic catheter venography demonstrated the occlusion, which was recanalized and dilated percutaneously via a transhepatic approach. Hepatomegaly and ascites decreased promptly and the prothrombin time became normal.

Angioplasty, Balloon↗
PubMed1988

The use of MRI to assist in diagnosis of pigmented villonodular synovitis of the knee joint.

Pigmented villonodular synovitis (PVNS) of the knee joint remains a difficult and elusive entity to define and characterize. This entity most often appears in the young adult knee with nonspecific clinical features, including a painful range of motion and perhaps a sensation of locking. Detection and diagnosis of this localized soft-tissue mass are difficult because plain roentgenograms may be totally within normal limits. The case of a 21-year-old woman illustrates the use of magnetic resonance imaging (MRI) as an effective technique to define and characterize PVNS. Advantages of MRI include high-resolution/high-contrast multiplanar sections that depict bone, marrow, ligaments and tendons, fat, menisci, and articular cartilage in one image. In addition, MRI is noninvasive and requires no ionized radiation. MRI is an excellent clinical tool for the evaluation of intraarticular tumors of the knee joint.

Adult↗
PubMed1987

MR imaging of the knee. Part I. Traumatic disorders.

One hundred thirty patients with a diversity of knee joint injuries were evaluated with a high-resolution magnetic resonance (MR) imaging technique. The authors report the accuracy of this technique in the evaluation of 105 patients with suspected meniscal tears, 26 patients with suspected cruciate ligament tears, and eight patients with suspected patellar tendon injuries. Of those menisci rated as definitely or probably torn on MR imaging, 80% were found to be torn at subsequent arthroscopy. The predictive value of negative MR imaging results was 100%. MR imaging was 92% accurate in predicting the clinical outcome in patients with suspected meniscal tears who did not undergo surgery. MR permitted complete disruption of the patellar tendon to be differentiated from partial tears, ligamentous inflammation, and localized effusion of the infrapatellar bursa. Injuries to the anterior and posterior cruciate ligaments were identified on MR images, and the status of synthetic grafts of the anterior cruciate ligament was ascertained.

Humans↗
PubMed1987

MR imaging of the knee. Part II. Chronic disorders.

Sixty patients with symptoms of chronic disease of the knee joint were evaluated with high-resolution, thin-section magnetic resonance (MR) imaging. MR imaging depicted a wide variety of knee joint abnormalities including osteochondritis dissecans, medullary infarcts, epiphyseal osteonecrosis, intraarticular osteochondral fragments, synovial cysts, joint effusions, intraarticular soft-tissue tumors, synovial disease, leukemic infiltration of bone marrow, Osgood-Schlatter disease, and nonossifying fibroma. In two cases MR imaging depicted bone infarcts not seen on both radionuclide bone scans and standard radiographs. The highly detailed depiction of the articular cartilage was of particular importance in predicting arthroscopic findings in cases of osteochondritis dissecans. In two cases, a soft-tissue mass (pigmented villonodular synovitis) and a large osteochondral fragment undetected at arthroscopy were accurately localized with MR imaging. The results indicate that MR imaging is capable of providing information that might otherwise require multiple, sometimes invasive diagnostic procedures.

Chronic Disease↗
PubMed1986

Meniscal injuries: detection using MR imaging.

Both retrospective and blinded analyses of thin-section, high-resolution magnetic resonance (MR) images of the knee joint, produced using a solenoid surface coil, indicate that MR imaging is an effective technique for evaluating meniscal injuries. Images of 49 patients were evaluated, and the results were correlated with those of subsequent arthroscopy. A grading scale was developed to rate the index of suspicion of a meniscal tear based on the MR images. Overall, approximately 80% of menisci rated grade 4 (definite tear) or 3 (probable tear) were found to have corresponding tears at arthroscopy. In many other patients with a grade 4 or 3 meniscus in whom a corresponding tear was not found arthroscopically, meniscal tears at other sites or other abnormalities were correctly diagnosed using MR. A majority of the false-positive MR images involved the posterior horns of the menisci, the sites of most false-negative arthroscopic diagnoses. The predictive value of a negative MR image was almost 100%. Even in patients with moderate-to-large effusions, the menisci were accurately evaluated. The results imply that MR imaging is useful in the preoperative evaluation of suspected meniscal tears.

Adolescent↗
PubMedDate not supplied

Magnetic resonance imaging as a tool for evaluation of traumatic knee injuries. Anatomical and pathoanatomical correlations.

Traumatic injury to the knee remains a diagnostic and therapeutic challenge. Magnetic resonance imaging (MRI) has been applied to musculoskeletal pathoanatomy and has been shown to be an effective tool for definition and characterization of knee pathology. A systematic approach is taken to establish anatomical and pathoanatomical correlations, as well as the role of MRI in the management of knee injuries. Imaging was performed at the UCLA Medical Center using a permanent magnet system and a combination of solenoidal surface coils and thin-section, high-resolution scanning techniques. Images depict structural anatomical and spatial details of the knee that correlate well with corresponding cadaveric cryosections. To determine pathoanatomical correlations and the efficacy of MRI, 105 patients with preoperative diagnoses of meniscal tears, anterior and posterior cruciate ligament tears, tibial plateau fracture, and patella and quadriceps injuries were imaged. Results indicated that for the medial meniscus MRI demonstrated a 95.7% sensitivity, 81.8% specificity, 90% accuracy, 88.2% positive predictive value (PPV), and 93.1% negative predictive value (NPV). Imaging of the lateral meniscus demonstrated a 75% sensitivity, 95% specificity, 91% accuracy, 80% PPV, and 94% NPV. MRI of the ACL revealed 100% sensitivity, specificity, accuracy, positive and negative predictive values. MRI is a noninvasive tool which uses no ionizing radiation and can accurately define and characterize anatomy and pathoanatomy. This study indicates that MRI in conjunction with clinical evaluation can contribute to treatment decision-making processes and assist in preoperative planning. An algorithm demonstrating the potential clinical use of MRI is presented.

Humans↗