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Biomedical subjects

S Hasan

Publications and source records attributed to S Hasan.

At least 55 records · Page 3Linked to original sources
PubMed1989

Effect of selective endoperoxide/thromboxane A2 receptor antagonism with sulotroban on tPA-induced thrombolysis in a rabbit model of femoral arterial thrombosis.

The thrombolytic efficacy of recombinant tissue-type plasminogen activator (tPA) in the presence and absence of the selective endoperoxide/thromboxane A2 (TXA2) receptor antagonist, sulotroban (BM 13.177, SK&F 95587) was studied in a model of femoral artery thrombosis in the anesthetized rabbit. The thrombus was formed by injection of thrombin, CaCl2 and whole blood into an isolated segment of the femoral artery. After 30 min of stable thrombotic occlusion of the femoral artery, tPA was infused IV for 90 min at doses of 5.0, 7.5 and 10.0 micrograms/kg/min. In other experiments, sulotroban was administered as a bolus dose of 1 mg/kg/IV, followed by a constant infusion of 1 mg/kg/hr concurrent with tPA infusion. Sulotroban had no effect on the incidence of tPA-induced reperfusion at any dose studied or on residual clot weight. However, at a tPA dose of 10 micrograms/kg/min, IV lysis time was reduced in sulotroban treated animals from 65 min to 29 min (P less than 0.05), and the magnitude of femoral artery blood flow achieved as a result of tPA-induced reperfusion was greater in sulotroban-treated animals. These data suggest that adjunctive therapy with a selective endoperoxide/TXA2 antagonist improves the response to tPA when tPA is administered at a maximal or near maximally effective pharmacological dose.

Animals↗
PubMed1988

A validation of a scoring system to evaluate the condition of transported very-low-birthweight neonates.

A scoring system was developed to objectively evaluate the condition of transported preterm infants. The "transport score" used five variables: blood glucose, blood pressure, pH, pO2, and temperature. Each variable was scored 0, 1, or 2, with a total achievable score from 0 to 10. Twenty-one matched pairs of infants included one infant who lived and one who died. The transport scores upon admission of infants who lived was significantly greater than the scores of those who died (P less than 0.01). Scores less than eight were predictive of death (sensitivity 62%, specificity 81%). The system was then applied prospectively to 106 different infants after stabilization by the hospital-of-origin (pre-transport) and upon admission to the neonatal intensive care unit (post-transport). Although 75 (76%) of the 99 surviving infants had both stabilization and admissions scores of eight or more, only 2 (29%) of the 7 infants who died had both scores of eight or more. Of 85 infants with a stabilization score of eight or greater, only 3 (3.5%) died, while of 21 infants with stabilization scores less than eight, 4 (19%) died. Similarly, of 90 infants with an admission score of eight or more, only 4 (4.4%) died, while of 16 with an admission score of less than eight, 3 (19%) died. We conclude that transport scores provide a valid indication of the condition of preterm infants and may be used to provide quality assurance for stabilization and transport efforts.

Academic Medical Centers↗
PubMed1988

The potential of antiestrogens as centrally-acting antihostility agents: recent animal data.

Recent studies suggest that motivations for certain forms of masculine behavior including social aggression are mediated by central estrogen receptors. Two studies using antiestrogens in rodent species were performed. Intact male LH rats were given Tamoxifen or vehicle for 4 or 8 days. The three possible pairings were videotaped for 60 min. Intact male OF1 mice were given CI-680 or vehicle over 25 days. Similar pairings were carried out but some CI-680 or vehicle animals were paired with anosmic opponents. Encounters were videotaped for 10 min. In both experiments evidence was obtained that the antiestrogen markedly reduced time allocated to offense. Any variations in defense were a consequence of the level of attack to which animals were subjected. Neither compound greatly influenced the androgen-dependent sex accessory glands. Antiestrogens consequently have potential as antihostility agents in some forms of attack.

Aggression↗
PubMed1988

Studies on the effects of the antiandrogen cyproterone acetate on social encounters between pairs of male mice.

An attempt was made in two experiments to reinvestigate the effects of the antiandrogen cyproterone acetate (CA) on mouse social behavior in a variety of ethologically-assessed paired encounters. The data confirm that CA reduces offense (threat and attack) in animals when both subjects receive the material but that CA has no such action in other pairings. This suggests that CA's major suppressive effect on "hostility" is expressed in mice via a reduction in "attack-promoting" pheromone production. Indeed, there was evidence in the more chronic study that CA, could augment (via a central mechanism?) offense in subjects paired with docile anosmic opponents. Changes in defense were largely responses to variations in the degree of attack to which animals were subjected. The antihormone also had actions on other aspects of behavior including sexual activity, social investigation and immobility in such tests. CA had a potent suppressive action on the weights of sex accessory glands. The data do not suggest that CA can be used as a specific antihostility agent.

Androgen Antagonists↗
PubMed1987

An evaluation of a computer program to predict the outcome of hyaline membrane disease.

A computerized model was developed to predict the severity of hyaline membrane disease. This study compared the program's predictive ability with that of three neonatologists. Blood gas and respiratory support data of 33 infants were entered into the computer which then predicted the severity of disease. The computer predicted 18 outcomes correctly. The neonatologists, provided with the same data, predicted 24 outcomes correctly. Both sets of predictions--computer and physician--found that patients predicted to have mild outcomes had the shortest oxygen requirements, duration of mechanical ventilation, and length of hospitalization, and infants predicted to have severe outcomes had the greatest oxygen requirements, duration of mechanical ventilation, and length of hospitalization. While actual severity was linked to birth weight, the model did not utilize birth weight in its predictive algorithm. Consequently, although the computer program predicted the outcomes with moderate success, it was less accurate than the neonatologists.

Blood Gas Analysis↗
PubMed1986

The prenatal diagnosis of ventral abdominal wall defects.

Ventral abdominal defects are frequently diagnosed by prenatal ultrasonography. This review of 47 infants with ventral defects was designed to determine the effect of prenatal diagnosis on neonatal outcome. All nine infants with prenatal diagnosis were delivered by cesarean section at tertiary level hospitals. Only 13 (34%) of 38 infants with unsuspected defects were delivered by cesarean section and 15 (39%) were delivered at tertiary level hospitals. There was no difference in mortality between infants with prenatal diagnosis (44%) and those with unsuspected defects (37%). Increased mortality correlated with the presence of other major anomalies (79% mortality), with birth weight less than 1500 gm (80%), and with omphaloceles (65%). We conclude that infants with other associated defects or with birth weight less than 1500 gm have poor outcomes and cesarean section may not be justifiable. However, in larger infants without other anomalies, prenatal diagnosis was followed by cesarean section and a good prognosis.

Abdominal Muscles↗
PubMed1986

The action of a dopamine (DA1) receptor agonist, fenoldopam in human vasculature in vivo and in vitro.

This study was designed to investigate dopaminergic mechanisms in human vasculature using the selective vascular dopamine receptor agonist fenoldopam in vivo and in vitro. In vivo, forearm blood flow was measured plethysmographically and in vitro isolated rings of human blood vessels from a variety of sites were used for tissue bath studies. Intra-arterial fenoldopam markedly increased forearm blood flow, this effect was antagonised by (R) sulpiride, a vascular dopamine (DA1) antagonist, but not by metoclopramide, a neuronal (DA2) antagonist, or by guanethidine, an adrenergic neurone blocking agent. In vitro, fenoldopam relaxed preconstricted human renal, mesenteric and lumbar arteries, but not saphenous vein in a concentration dependent manner. (RS) sulpiride and SCH 23390 competitively antagonised this effect. These studies demonstrate the presence of a vasodilatory vascular dopamine receptor in man both in vivo and in vitro.

Adolescent↗
PubMed1986

Importance of using standardized birth weight increments to report neonatal mortality data.

Neonatal mortality statistics are frequently reported in 100-g increments of birth weight. We tabulated our mortality statistics using two methods of incrementation: 500 to 599 g, 600 to 699 g, 700 to 799 g, etc. (method A) and 501 to 600 g, 601 to 700 g, 701 to 800 g, etc (method B). In each 100-g weight group, the mortality was less using method B. The average reduction in mortality using method B was 4.1%. Use of the two different methods creates difficulty in making meaningful comparisons of various published reports. We recommend that all future studies use method A, as that method is more consistent with previous recommendations of the World Health Organization.

Birth Weight↗
PubMed1985

Human vasodilator responses to a dopamine agonist: possible mechanisms.

The action of fenoldopam, a selective dopamine DA1 agonist, on resting forearm blood flow was studied in healthy male volunteers by venous plethysmography. Metoclopramide and (+/-) sulpiride were used as dopamine antagonists. Intra-arterial fenoldopam over the range (100 ng/min to 1 microgram/min) produced a dose-related increase in forearm blood flow without evidence of systemic effects. The response to fenoldopam was not antagonized by metoclopramide or (+/-) sulpiride and neither antagonist alone altered resting forearm blood flow. It is unclear whether the effects of fenoldopam in the forearm vasculature are mediated through the vascular dopamine receptor.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗
PubMed1981

The aims and methods of physiotherapy in field conditions in the National Leprosy Control Programme.

The main aim of physiotherapy in field conditions in National Leprosy Control Programme is preventive rehabilitation which can be achieved by systematic recording and reporting on the individual deformity status of all the patients followed by standardized methods of preventive management at peripheral clinics run single handedly by para-medical workers. The few patients in acute conditions and still fewer in need of surgical rehabilitation etc, require special reporting and special attention afforded by collective efforts of all the categories of workers engaged at a control unit. The system of reporting on deformity based on the W.H.O. Classification of deformities (1960) and of preventive management introduced at the Leprosy Control Unit, West, Hyderabad is found to be appropriate, statistically appreciable and sound in principle. The idea to avoid surgeon's knife and sophisticated methods of physical rehabilitation in field work as much as possible, and yet achieve the objectives of preventive rehabilitation of leprosy patients is feasible and successfully maintainable.

Face↗
PubMed1977

A survey of leprosy deformities among the patients of Hyderabad city.

Neuropathic deformity is a major problem among the patients of Hyderabad city. Nearly 44.3% of the patients have one or the other kind of deformity of the hand, foot or face. 29.1% of the upper limbs, 30.7% of the lower limbs and 5.2% of the faces were affected. The patients with Lepromatous Leprosy showed greater tendency to deformity (66.4%). Patients with simply anaesthesia in hands and feet formed the majority among the deformity cases, a total of 41.6%. Education of the patients in the hand and foot care is an essential feature of the clinic physiotherapy technician.

Adolescent↗