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Biomedical subjects

S Heaton

Publications and source records attributed to S Heaton.

7 recordsLinked to original sources
PubMed1979

Comparison of natriuretic, uricosuric, and antihypertensive properties of tienilic acid, bendrofluazide, and spironolactone.

The antihypertensive properties of the new diuretic tienilic acid were investigated. Thirteen previously untreated hypertensive patients took part in a double-blind crossover study in which 30 days' treatment with tienilic acid 250 mg, bendrofluazide 5 mg, and spironolactone 100 mg were compared. Bendrofluazide caused the greatest natriuresis on the first treatment day and the most rapid fall in blood pressure. The ultimate antihypertensive effect of all three drugs was similar. Tienilic acid caused a noticeable reduction in serum urate concentrations and a rise in urate clearance, in contrast to the other two agents, which caused slight urate retention. Tienilic acid and bendrofluazide caused falls and spironolactone a rise in plasma potassium concentrations. No untoward effects were seen from any of the drugs. It is concluded that tienilic acid is a moderately potent diuretic that lowers plasma urate concentrations. It may be the drug of first choice for hypertensive patients who already have gout or are likely to develop it when taking thiazide diuretics.

Bendroflumethiazide↗
PubMed1979

Dose response for blood pressure and degree of cardiac beta-blockade with atenolol.

The hypotensive effect of 25 mg, 50 mg, 75 mg, 100 mg and 0 mg of atenolol daily were compared in a double-blind within-patient study. The fall in blood pressure with 25 mg daily was not significantly different than with 100 mg. The dose response curve lies between 0 and 25 mg daily. Cardiac beta-blockade (measured by suppression of exercise tachycardia) was not maximal with 25 mg of atenolol daily. The dose response curves for beta-blockade and the hypotensive effect are not parallel.

Adult↗
PubMed1976

Comparison of oxprenolol and methyldopa in hypertension. A within-patient double-blind trial.

Oxprenolol or methyldopa were administered in double-blind fashion to 29 patients shown to be persistently hypertensive. After a dose-finding, assessment, and washout period, the second drug was given. 24 patients completed a period of treatment with each drug. Blood-pressure falls were similar with each drug in the supine, standing, and post-exercise state. Half the patients responded will to low dosage (oxprenolol less than or equal to 320 mg, methyldopa less than or equal to 1 g, a day) and 9 of 11 such patients responded satisfactorily to each drug. In those whose response was inadequate, oxprenolol was increased to 960 mg or methyldopa to 3 g a day. Increasing dosage had no consistent pressure-lowering effect. Side-effects were assessed by questionnaire and no clear preference emerged. It is recommended that an inadequate response to modest dosage of either drug should lead to the use of an additional agent rather than heavier dosage.

Adult↗
PubMed1976

Clostridia isolated from faeces.

Clostridia were isolated from human faecal samples from England, Scotland, Wales, USA, Hong Kong, Uganda and Japan. Strains were identified on the basis of various biochemical reactions and on the type of fatty acid produced from glucose. Analysis of these acids was by gas-liquid chromatography. Clostridium paraputrificum was common in stool samples from England, Scotland, Wales, and USA, but rare in samples from Hong Kong, Uganda and Japan.

Adult↗