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Biomedical subjects

S Henley

Publications and source records attributed to S Henley.

11 recordsLinked to original sources
PubMed1989

The Type A behaviour pattern and self-evaluation.

This paper is concerned with how Type A and B subjects perceive themselves. Subjects first completed a unidimensional A type measure, then rated themselves and their ideal selves on various personality traits. As expected, Type A was associated with negative self-ratings and high actual-ideal self-discrepancy scores. However, it is argued that self-evaluation in negative terms by Type As is not necessarily synonymous with low self-esteem. Negative self-ratings may be an important factor in the aetiology and maintenance of the Type A behaviour pattern.

Adult↗
PubMed1989

The effects of platelet-derived growth factor in cultured microvessel endothelial cells.

The effects of platelet-derived growth factor (PDGF) on thymidine incorporation into DNA and glucose and neutral amino acid uptake were studied in endothelial cells cultured from macrovessels (bovine aorta and pulmonary artery) and microvessels (bovine fat and mouse brain). Similar to previous studies, PDGF did not bind to macrovessel cells, nor did it influence their metabolic function. In contrast, PDGF bound specifically to the two types of microvessel cell culture and in these cells also stimulated the uptake of glucose and neutral amino acids as well as the incorporation of thymidine into DNA. Stimulatory effects of PDGF occurred at concentrations of 2 ng/ml, with maximal stimulation up to 5-fold of the control value for amino isobutyric acid and glucose uptake and up to 8- to 10-fold for thymidine incorporation. The maximal effects of PDGF were additive to those of insulin-like growth factor, I, a known stimulator of all three metabolic processes in microvessel endothelial cells. The binding of PDGF to the endothelial cells was, in general, equivalent to PDGF binding to human foreskin fibroblasts, both in the magnitude of tracer binding and in the affinity of binding. Similar effects were found with recombinant and platelet-derived PDGF. We conclude that these two cultured microvessel endothelial cells not only produce PDGF-like material, but are capable of binding and responding to PDGF.

Adipose Tissue↗
PubMed1988

The attribution of cure.

Subjects rated the importance of 24 different contributors towards overcoming four relatively common problems: alcoholism, depression, sexual problems and shyness. Factor analysis revealed seven almost identical clusters for each problem, which were labelled inner control, receiving help, understanding, social consequences, physical basis, avoidance and fate. Items loading on the first three factors were thought to be generally important, and those on the last three relatively unimportant. However, the degree of importance attributed to each factor varied considerably between problems.

Adolescent↗
PubMed1987

Prophylactic antiarrhythmic therapy of high-risk survivors of myocardial infarction: lower mortality at 1 month but not at 1 year.

To determine whether prophylactic antiarrhythmic therapy influences mortality in high-risk patients after acute myocardial infarction, 143 such patients were randomized in a double-blind individually dose-adjusted, placebo-controlled trial an average of 14 +/- 7 days after myocardial infarction and followed for 1 year. Patients were judged to be at high risk on the basis of (1) ejection fraction less than 40% (n = 60), (2) arrhythmias of Lown class 3 or higher (n = 26), or (3) both (n = 57). Aprindine was chosen because of its long half-life, few side effects, and antiarrhythmic efficacy. Baseline characteristics in the treatment arms did not differ. Holter-detected arrhythmias were reduced in aprindine-treated patients at 3 months (p less than .001) and at 1 year (p less than .001). One patient was lost to follow-up; in the remaining patients 1 year mortality was 20% (28/142; 12 aprindine and 16 placebo). There was no significant difference between the two study arms in overall mortality and sudden death. However, among those who died, median duration of survival was longer in aprindine-treated patients (86 vs 21.5 days) (p = .04). Although antiarrhythmic treatment with aprindine of high-risk patients after myocardial infarction does not affect 1 year survival, mortality appears to be delayed; thus there may be a role for short-term treatment before more definitive therapy such as surgery.

Aprindine↗
PubMed1986

A new projective test: the Caine-Marteau-Dympna Test (CMD).

The Caine-Marteau-Dympna (CMD) Test, a new thematic apperception projective test, has acceptable inter-rater reliability. Validity was demonstrated by its ability to differentiate psychiatric in-patients from out-patients and non-patients, and by the relationships found between ratings derived from the test protocols and various questionnaires. These latter provide measures associated with either an inner or outer orientation towards the world. This has implications for many different areas of life, including occupational preference and adjustment, psychiatric symptom formation, psychological treatment expectancies and therapeutic outcome. Thus, the inner oriented individual, who is likely to be responsive to interpretative psychotherapy, tends to produce CMD responses displaying individualistic, abstract themes; a concern with intrapsychic conflict, deficiencies in social interaction and lack of structure; and internal control.

Adult↗
PubMed1986

Type A behaviour pattern, the recall of positive personality information and self-evaluations.

This paper reports on two studies of how Type A and B subjects perceive themselves. Both studies investigated differences in self-ratings of personality by Type As and Bs, and differences in the recall of positive and negative personality information. As predicted, a modest significant positive correlation was found in both studies between Type A scores and number of positive traits remembered, suggesting that Type A behaviours are associated with a tendency to process information about the self in such a way as to bolster self-esteem. Self-ratings of positive and negative personality traits showed that Type As tended to rate themselves much more negatively than Type Bs. This provides support for a self-evaluative model of Type A behaviour. The results are discussed in terms of the paradoxical nature of the Type A behaviour pattern.

Adult↗
PubMed1985

Who goes home? Predictive factors in stroke recovery.

One hundred and seventy two stroke patients were assessed two weeks post-stroke by a multi-disciplinary team. The predictive ability of a number of variables, including social, psychological and physical factors, was estimated for four outcome groups. Highly significant factors for good and bad outcome for one year were identified.

Activities of Daily Living↗