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Biomedical subjects

S Henschen

Publications and source records attributed to S Henschen.

8 recordsLinked to original sources
PubMed2005

[Diagnosis and therapy of gestational diabetes--comparison of two surveys of established gynecologists in Berlin and Saxonia-Anhalt ].

PURPOSE: The diagnosis and treatment of gestational diabetes mellitus is controversial. We undertook a survey of obstetricians/gynaecologists to identify current screening practices and differences between Saxonia-Anhalt and Berlin. METHODS: A questionnaire was sent to 267 practicing obstetricians/gynaecologists in Saxonia-Anhalt and 441 in Berlin. The questionnaires included items on the diagnosis and treatment of gestational diabetes. RESULTS: A response rate of 37 % in Saxonia-Anhalt and 35 % in Berlin was achieved. 90 % of the respondents would welcome the integration of a general screening for gestational diabetes into the standard German prenatal care plan. In spite of this great support only 37 % of the obstetricians/gynaecologists in Saxonia-Anhalt and 36 % in Berlin screened their patients generally. Important risk factors for the screening were rarely or not mentioned. CONCLUSION AND DISCUSSION: The survey confirms disparate policies regarding the screening for and treatment of gestational diabetes. There are differences between Saxonia-Anhalt and Berlin. This can only be changed by appropriate inclusion in the German prenatal care plan.

Attitude of Health Personnel↗
PubMed2000

Orthotopic liver transplantation for complicated HELLP syndrome. Case report and review of the literature.

A case of hepatic complication in a pregnant woman suffering from HELLP syndrome resulting in the need for transplantation is reported, and an algorithm for those instances is suggested. According to the literature, this is the 5th report of hepatic complications in HELLP syndrome necessitating liver transplantation. Since all but one of the transplanted patients survived (as opposed to a high mortality in non-transplanted patients), it is concluded, that a timely decision for transplantation is a safe option in this high risk group.

Adult↗
PubMed1993

Plasma volume estimation using indocyanine green. A single intravenous injection method.

The validity and reliability of plasma volume estimation using indocyanine green were investigated in five in vitro experiments and in three in vivo series. The in vitro measurements reflected real volumes with an error of about 1%. Comparative measurements in the same patients using indocyanine green or Cr51 labelled red cells differed by 1.7% (r = 0.97). The mean (SD) plasma volume difference between two successive plasma volume measurements using indocyanine green was 38 (43) ml (r = 0.99). Plasma volume measured before and about 7 min after a hyperosmolar saline bolus (100 ml, 1 molar) was increased by 223 (102) ml and 286 (49) ml when determined by indocyanine green and plasma protein changes respectively. Nevertheless, the necessity for central venous injection and arterial sampling restricts the possible application of the method to intra-operative or emergency care use.

Blood Volume Determination↗
PubMed1991

Short term volume effects of a hypertonic saline bolus during neurosurgery.

Intracranial hypertension which does not respond to customary hyperosmotic agents may successfully be treated with hypertonic saline. The absence of diuresis and the maintainance of intravascular volume are supposed to be the main advantages of hypertonic sodium chloride. Volume overload and toxic hyperosmolality from frequent application of such solutions are possible disadvantages. The presented experiments checked the time course of intravascular volume shifts after a 100 ml 1-molar saline bolus in 14 patients during neurosurgery using plasma protein concentration changes. An initial intravascular volume expansion of about 270 ml remained quite unchanged for the first 8 minutes, followed by a nearly linear decrease. Extrapolation of the curves demonstrated that the preinfusion state would have been reached after about 20 minutes. Osmolality remained increased by about 4 mosmol/kg 15 min after the bolus. Thus it appears that repetitive infusion of these amounts of hypertonic saline will cause no serious volume overload if 30 minutes intervals are kept, but osmolality should be checked before each bolus.

Adult↗
PubMed1990

Determination of circulating blood volume by measurement of indocyanine green dye in hemolysate: a preliminary study.

In 8 emergency care patients blood volume was determined using Cr5I labelled erythrocytes and indocyanine green (ICG). Prior to measurement of ICG in blood with a spectrophotometer, the blood was hemolyzed with Triton-X. A close correlation of r = 0.97 between the Cr51 and the ICGTR-X estimates was found; the ICGTR-X volume was about 3% lower than the Cr51 volume. In five additional in vitro experiments the ICGTR-X method was found to reflect real volumes with an insignificant error of less than 1%. Blood volume determination with ICGTR-X cannot be applied in cases of circulatory failure. ICG should be administered in a dose of 0.5 mg/kg of body weight. For calibration purposes, a two point calibration curve (point 1: point of intersection of x and y axis; point 2: 5 mg ICG/1 of blood) is sufficient. From these preliminary experiments it is concluded that the ICGTR-X method is a rapid and simple technique of blood volume determination with multiple reproducibility which can be carried out in any clinical laboratory.

Blood Volume Determination↗