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Biomedical subjects

S Hervei

Publications and source records attributed to S Hervei.

At least 19 recordsLinked to original sources
PubMed1981

"Dot-17 alpha-hydroxyprogesterone" radioimmunoassay for identification of congenital adrenal hyperplasia in young infants.

Using a simplified radioimmunoassay method for the determination of 17-hydroxyprogesterone (17-OHP) concentration in blood dried on filter paper seven untreated cases of congenital adrenal hyperplasia were identified among newborns and infants at risk for congenital adrenal hyperplasia (CAH) having ambiguous genitalia and/or failure to thrive with electrolyte disturbances. In three additional cases the diagnosis of congenital adrenal hyperplasia was confirmed by high 'dot-17-OHP' values even after glucocorticoid therapy had been started. Capillary blood samples taken in a local hospital on a filter paper routinely used for the screening of phenylketonuria can be sent by mail into a central laboratory for performing the analysis. Assays of 'dot-17-OHP' are clearly of diagnostic value in the C21-hydroxylase form of CAH and permit a rapid diagnosis of this condition in the newborn period.

Adrenal Hyperplasia, Congenital↗
PubMed1977

[Hearing- and vestibular functions after neonatal hyperbilirubinaemia (author's transl)].

Cochlear- and vestibular function were investigated in 72 patients, aged between 4 and 7 years who had neonatal hyperbilirubinaemia. Markedly more and more serious damage was found in the group of patients, who as neonates had serum bilirubin levels above 25 mg-%. The frequency of loss of cochlear and vestibular function was significantly higher in patients with hyperbilirubinaemia for more than 4 days. Contrary to data published until now, it can be concluded that the vestibular apparatus is the most sensitive part of the nervous system to bilirubin.

Audiometry↗
PubMed1976

Acid-base changes of mature and premature neonates following exchange transfusion.

The changes of acid-base values of 60 mature and premature neonates treated by exchange transfusion were followed. It could be shown that the blood conserves having acidic pH values caused no acidosis if the acid-base balance of the patients had been normal before transfusion. An existing acidosis frequently increased significantly in the first day of life of the mature but also in the later days in premature neonates. Thus, the determination of acid-base state prior and after transfusion of such patients seems to be important. In the case of pronounced acidosis its correction and also the control of the acid-base values after the exchange transfusion are necessary.

Acid-Base Equilibrium↗
PubMed1976

[Hypoglycaemia in neonates following exchange transfusion (author's transl)].

In 30 newborns the blood sugar level was determined before and after exchange transfusion. At the end of exchange transfusion, the blood sugar reached in each case 200 mg-% or more, but with in one hour fell back to the starting level. If the patient did not get an adequate quantity of sugar during that time, hypoglycaemia developed. It is known, that patients with severe haemolytic disease have hyperinsulinism, but we investigated only such patients, who were born with Hgfv levels above 10 g-%. Therefore, it seems, that the hypoglycaemia in those cases is not due to the haemolytic disease, but a reaction to the sugar, given with the ACD blood.

Blood Glucose↗