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Biomedical subjects

S Heyman

Publications and source records attributed to S Heyman.

At least 19 recordsLinked to original sources
PubMed2001

Medical relief operation in rural northern Ethiopia: addressing an ongoing disaster.

BACKGROUND: Following the recent drought in Ethiopia, the Jewish Agency, aided by the Israel Ministry of Foreign Affairs, launched a medical relief mission to a rural district in Ethiopia in May-August 2000. OBJECTIVES: To present the current medical needs and deficiencies in this representative region of Central Africa, to describe the mission's mode of operation, and to propose alternative operative modes. METHODS: We critically evaluate the current local needs and existing medical system, retrospectively analyze the mission's work and the patients' characteristics, and summarize a panel discussion of all participants and organizers regarding potential alternative operative modes. RESULTS: An ongoing medical disaster exists in Ethiopia, resulting from the burden of morbidity, an inadequate health budget, and insufficient medical personnel, facilities and supplies. The mission operated a mobile outreach clinic for 3 months, providing primary care to 2,500 patients at an estimated cost of $48 per patient. Frequent clinical diagnoses included gastrointestinal and respiratory tract infections, skin and ocular diseases (particularly trachoma), sexually transmitted diseases, AIDS, tuberculosis, intestinal parasitosis, malnutrition and malaria. CONCLUSIONS: This type of operation is feasible but its overall impact is marginal and temporary. Potential alternative models of providing medical support under such circumstances are outlined.

Adolescent↗
PubMed1999

131I MIBG therapy in neuroblastoma: mechanisms, rationale, and current status.

131I MIBG has been used as palliative treatment of neuroblastoma patients with recurrent or persistent disease who failed other modalities of treatment. Since the results were promising, the concept arose of using it in conjunction with other modalities, either as an up-front treatment or as combination therapy. This article reviews the principle of 131I MIBG treatment, in conjunction with other modalities currently used for the treatment of neuroblastoma, in an attempt to improve the final outcome.

3-Iodobenzylguanidine↗
PubMed1998

Gastric emptying in children.

This article reviews the evaluation of gastric emptying in children with emphasis on scintigraphic techniques. The mechanism of emptying as well as how quantitation may vary with patient positioning, the composition of the standard meal and possibly the size of the meal are discussed. Preliminary data suggest that for children under the age of 2 yr, meal size is less critical. Although normal ranges need to be determined by individual laboratories, values reported in the literature may be used as a guide. Quantitation is useful for the follow-up of patients on therapy.

Child↗
PubMed1997

Gastric emptying of milk feedings in infants and children. Anterior versus conjugate counting.

UNLABELLED: The radionuclide milk scan is a valuable tool for the evaluation of gastroesophageal reflux and gastric emptying in children. There is uncertainty as to whether anterior imaging alone is sufficient for determining gastric emptying in these patients. METHODS: Twenty-five children underwent Tc-99m sulfur colloid milk scans with images acquired in the anterior and posterior projections. Calculations of the 1 hour and 2 hour percentage of gastric residual activity were performed using the anterior counts alone and the geometric mean of the anterior and posterior counts. The anterior and posterior images were visually assessed for the presence of gastroesophageal reflux. RESULTS: The means of the absolute differences at 1 and 2 hours for the two methods of gastric residual calculation were 4.1% +/- 2.1% and 3.4% +/- 2.8%, respectively. There was good correlation between the two methods at 1 and 2 hours with r values of 0.991 and 0.997 respectively. Gastroesophageal reflux was more obvious in the anterior images and three small episodes were only seen on the anterior view. CONCLUSION: Anterior images alone give reliable results for the determination of gastric emptying, and gastroesophageal reflux is more readily visualized anteriorly in the pediatric population.

Adolescent↗
PubMed1997

Volume-dependent pulmonary aspiration of a swallowed radionuclide bolus.

The radionuclide salivagram was introduced as a simple physiologic technique to document the aspiration of saliva in patients with chronic lung disease. We previously reported positive studies to be prevalent in patients with neuromuscular incoordination, as with cerebral palsy, or after surgery involving the upper airway. Many patients referred for a salivagram, however, have an apparent intact swallowing mechanism and are better challenged with a tagged bolus.

Child↗
PubMed1997

Reversed ventilation-perfusion mismatch involving a pediatric patient in congestive heart failure.

Over the past 13 yr, at least 11 specific etiologies of reversed ventilation-perfusion mismatch have been reported in the literature. In this article, a case of reversed ventilation-perfusion mismatch involving a patient in congestive heart failure receiving dobutamine and milrinone therapy is presented. A brief review of the topic of reversed ventilation-perfusion mismatch is presented.

Adolescent↗
PubMed1997

Assessment of gastro-esophageal dysfunction in children.

Scintigraphic methods to assess esophageal transit, gastro-esophageal reflux and gastric emptying are widely used in pediatric patients. This review describes the methodology and considers the clinical application of these techniques as well as the utility of alternative diagnostic studies.

Child↗
PubMed1996

Results of dacryoscintigraphy in massage of the congenitally blocked nasolacrimal duct.

Between November 1990 and November 1993, 580 children with lacrimal outflow obstruction were examined at the Children's Hospital of Philadelphia. After excluding patients previously treated for nasolacrimal duct obstruction, we obtained a prospectively selected series of 20 children for this study. These patients underwent dacryoscintigraphy before and immediately after lacrimal sac massage to investigate the effect of external compression on fluid movement within the lacrimal outflow system. In 12 patients, tracer did not enter the lacrimal outflow system on the side(s) of obstruction. The absence of radiopharmaceutical correlated with clinical obstruction. In eight patients, tracer was noted to enter the lacrimal sac. After massage of the lacrimal sac, we observed progression of the tracer in five of the eight subjects. In these eight subjects, the pre- and postmassage tear column measurements showed a relative increase of 34.3%. Massage of eight clinically normal ducts showed a relative increase of 2.4% (p = 0.06). We conclude that progression of the tear column after lacrimal massage can be demonstrated on dacryoscintigraphy.

Child, Preschool↗
PubMed1996

Fetal mouse lung ultrastructural maturation is accelerated by maternal thyrotropin-releasing hormone treatment.

Maternal administration of thyrotropin-releasing hormone, alone or in combination with corticosteroid, accelerates functional, morphologic and biochemical fetal lung maturation. However, the dose-response relationship of maternal thyrotropin-releasing hormone treatment and acceleration of fetal lung ultrastructural maturation or disaturated phosphatidylcholine content has not been investigated. We administered (i.p.) saline or thyrotropin-releasing hormone (0.2, 0.4 or 0.6 mg/kg/dose) to the pregnant Balb/c mouse on days 16 and 17 (b.i.d.) and on day 18 of gestation (1 h prior to killing). Morphometric ultrastructural analysis and quantitation of disaturated phosphatidylcholine content was done on the 18-day gestation fetal lung. Maternal thyrotropin-releasing hormone treatment resulted in an increase in the number of lamellar bodies and depletion of glycogen in fetal lung type II cells, and an increase in the lung airspace to parenchymal ratio. In addition, a striking difference in the pattern of lung growth was noted in the thyrotropin-releasing-hormone-treated (0.4 and 0.6 mg/kg/dose) groups. These lungs had larger air spaces, thinner alveolar septae and more air-blood barriers. Maternal thyrotropin-releasing hormone treatment did not influence fetal lung disaturated phosphatidylcholine content. We conclude that in the mouse, maternal thyrotropin-releasing hormone treatment enhances fetal lung structural maturation and propose that thyrotropin-releasing hormone plays a role in mammalian fetal lung growth.

Animals↗
PubMed1995

Pediatric gastrointestinal motility studies.

Radionuclide studies for evaluating gastrointestinal transit in adults have been adapted for use in infants and children for assessing esophageal transit, gastroesophageal reflux, and gastric emptying. However, the measurement of small- and large-bowel transit times in these patients has been limited.

Child↗
PubMed1995

Langerhans cell histiocytosis: presentation and evolution of radiologic findings with clinical correlation.

Radiologic images and medical records of 42 children with Langerhans cell histiocytosis (LCH) (histiocytosis X) were reviewed to evaluate the presentation of the disease and the evolution of the radiologic findings. There were 26 male and 16 female patients aged 3 months to 18 years. Twenty-two patients presented with localized disease; 20 presented with multifocal disease. Four patients developed diabetes insipidus. Two patients had organ dysfunction. The radiologic findings were largely due to destructive bone lesions; 83% of the patients had at least one affected bone. Isolated soft-tissue masses, interstitial lung disease, and central nervous system abnormalities were also seen. Of patients in whom results of appropriate follow-up were available, 91% showed improvement in their lesions, 43% developed new lesions, and 92% had good clinical outcomes. LCH is usually a self-limited disease with a varied clinical and radiologic presentation. The prognosis is generally poor in children with organ dysfunction. In the absence of organ dysfunction, children with either localized or multifocal LCH have an excellent prognosis.

Adolescent↗
PubMed1995

Radionuclide studies of the upper gastrointestinal tract in children with feeding disorders.

The case of a female infant with a feeding disorder and with inadequate growth is described. In her workup, there was no evidence of an organic disorder. Barium studies of the upper GI tract showed normal anatomy and function. A radionuclide milk scan was helpful in demonstrating mild reflux and significantly delayed gastric emptying. There was a good response to therapy.

Animals↗