Biomedical subjects

S Hick

Publications and source records attributed to S Hick.

4 recordsLinked to original sources

PubMed2002

[Corneal ulcers associated with rheumatoid arthritis].

Keratoconjonctivitis sicca, scleritis and keratitis remain the major ocular manifestation, associated with rheumatoid arthritis. Corneal ulcers are a rare complication but can lead to perforation. Unstable epithelial barrier and immune disorders play a key role in the pathophysiology of such corneal melting. Moreover the association with systemic vasculitis reveals the need for an appropriate immunosuppressive treatment. New surgical approaches and early immunotherapy allow to maintain ocular integrity even if the visual prognosis is poor.

Arthritis, Rheumatoid↗

PubMed2000

[Refractive power evolution following cataract surgery].

A retrospective study was carried out to evaluate and quantify the refractive power evolution following cataract procedure. Three different intraocular lenses were compared: Corneal ACR6D (acrylic), Kelios 600 (silicone), Storz HM60 (hydrogel). Visual acuity and post-operative refraction were compared at one week and after two months. The spherical equivalent change after those follow-ups shows the refractive evolution. Refraction is stable with time for the Storz and Kelios lenses. However, post-operative hyperopia was found for monobloc Corneal implant.

Acrylic Resins↗

PubMed1995

Isolation of the endothelin B receptor from bovine lung. Structure, signal sequence, and binding site.

Bovine lung endothelin-B receptor has been isolated in good yield with a new procedure involving the use of endothelin-1 coupled to iminobiotin with a long spacer and avidin-agarose affinity chromatography. Contrary to previous reports, evidence has been obtained that the native form of this receptor corresponds to the full-length transcript expected on the basis of cDNA clones. The binding of endothelin to a variety of shortened fragments of the full receptor suggests that the long N-terminal sequence of this receptor has very little influence on the binding of endothelin and that the main determinants of the endothelin binding site might be constituted by residues in the sixth, and possibly the seventh, transmembrane helices.

Amino Acid Sequence↗

PubMed1995

Isolation of endothelin A receptor from bovine lungs.

We isolated endothelin receptor A (ETA) from bovine lungs in a single-step purification procedure using antibodies raised against synthetic peptides that correspond to extra- and intracellular domains of the rat bradykinin receptor. Two receptor species of 55 and 35 kDa were isolated and subjected to N-terminal microsequencing. The difference between the observed and expected molecular weight species suggests that bovine ETA receptor is glycosylated.

Animals↗