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Biomedical subjects

S Hidalgo

Publications and source records attributed to S Hidalgo.

4 recordsLinked to original sources
PubMed1992

[Accidental exposure to health care workers of blood and body fluids from patients].

Due to the growing concern of Health Care Workers (HCW) regarding the possibility of acquiring blood borne infections through accidental occupational exposure and the fact that HIV and Hepatitis B infections have occurred in that setting, an evaluation of the frequency of accidents and their circumstances, suffered by HCW with blood or body fluids from patients was carried out. 1,340 self administered questionnaires were given to HCW with direct contact with patients in a general 800 beds hospital, requiring information of accidental percutaneous, mucosal or cutaneous (it not intact) exposures to blood or certain (risky) body fluids ever and/or in the last 6 months. Sixty five percent of HCW referred some exposure ever and 46% in the last 6 months. The rate of exposure ever ranged from 36.6% in medical students to 69.5% in doctors, 78.5% in nurses to 100% in dentists. Seventy seven percent of the exposures were seen during routine care, 28.5% were perceived as due to personal carelessness, 19.9% due to patient agitation, 33.5% as inherent to the procedure and 8.9% to abandonment of material. Exposures were mostly to blood. One hundred eleven out of 331 (33.5%) exposures were produced during handling of syringes; 33.2% during invasive procedures and 13% during cleaning of material. Sixty out of 107 (56%) non surgical doctors (NSD) and 61/67 (92.5%) of surgical doctors (SD) had had exposures ever (p < 0.01), 16.8% and 65.6% had had one or more in the last 6 months respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Accidents, Occupational↗
PubMed1990

[Autoimmune polyglandular syndrome. Clinical experience in 21 cases].

The autoimmune polyglandular syndrome is characterized by the association of 2 or more endocrine disorders of autoimmune origin which may coexist with autoimmune disorders in other organs. Roughly 25% of patients with an autoimmune endocrinopathy show evidence of autoimmune disease elsewhere. We report 21 patients with autoimmune polyglandular syndrome classified according to Neufeld.

Adult↗
PubMedDate not supplied

Y chromosome sequences in Turner's syndrome: association with virilization and gonadoblastoma.

UNLABELLED: The presence of Y chromosome fragments in patients with Turner's syndrome is known to increase the risk of gonadoblastoma and virilization. Y chromosome material is detected in up to 6% of patients with Turner's syndrome by karyotype. By DNA analysis, Y chromosome sequences have been reported in 0-60% of patients. The putative gonadoblastoma gene has been mapped to the pericentromeric region of the Y chromosome increasing the interest in studying these sequences. AIMS: 1. To determine the frequency of occult Y chromosome sequences in patients with Turner's syndrome. 2. To analyze the clinical implications of Y sequences detected by karyotype and occult Y sequences. STUDY DESIGN: Cross-sectional study of 58 patients with Turner's syndrome (30 45,X; two with structural anomalies; 26 mosaic [two of whom were 45,X/46,XY]). SRY, TSPY and DYZ3 sequences were amplified by PCR using genomic DNA from peripheral blood. RESULTS: All three Y chromosome sequences were found in one out of 56 patients whose karyotype was not suggestive of having Y chromosome material and in one patient with 45,X/46,Xr(X) karyotype. The patients with the ring chromosome and 45,X/46,XY karyotype underwent surgery and were found to have a gonadoblastoma and dysgerminoma. The four patients with Y chromosome material had non-virilized female genitalia. CONCLUSIONS: Analysis by PCR was more sensitive in detecting Y chromosome sequences than conventional karyotype. The presence of Y material was not associated with virilization. We confirmed the association of Y fragments and gonadoblastoma at an early age.

Adolescent↗