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S Hinz

Publications and source records attributed to S Hinz.

6 recordsLinked to original sources
PubMed1999

The guide RNA database (3.0).

The RNA editing process within the mitochondria of kinetoplastid organisms is controlled by small, trans -acting RNA molecules referred to as guide RNAs. The guide RNA database is a compilation of published guide RNA sequences, currently containing 254 entries from 11 different organisms. Additional information includes RNA secondary and tertiary structure models, information on the gene localisation, literature citations and other relevant facts. The database can be accessed through the World Wide Web (WWW) at http://www.biochem.mpg.de/ goeringe/

Animals↗
PubMed1997

Histological and biochemical changes induced by total bile duct ligation in the rat.

The aim of the present investigation was to assess in a correlated biochemical and morphological study the dynamics of fibrogenesis after bile duct ligation and to compare the time course of alterations with those occurring in thioacetamide induced liver fibrosis. The data show that, after bile duct obstruction, the deposition of connective tissue elements and formation of ductular proliferates rapidly set in. The index of fibroplasia correlated well with the changes of the OH-proline concentration of the liver. Comparing the biliary fibrosis with the thioacetamide induced liver fibrosis, the progress of the former occurred more rapidly, even though in both cases only a few necroses were observed. Therefore, we suggest that in biliary fibrosis other mechanisms are responsible for the rapid onset of production of extracellular material and proliferative processes than in thioacetamide-induced liver fibrosis.

Alanine Transaminase↗
PubMed1993

[Isolation and characterization of hepatocytes from chronic cholestatic damage to rat livers after bile duct ligation].

The aim of these investigations was the isolation and characterisation of hepatocytes from chronic injured rat livers after bile duct ligation. In three months old female Uje:WIST rats the distal common bile duct was double ligated. 14 days after the ligation 80% of the rats survived. The content of hepatic OH-prolin was increased in relation to shamoperated control animals. The histological examination showed a marked fibrous and oedematous spreading of the portal tract as well as an extensive bile duct proliferation after 14 days. A correlation between OH-prolin content of the liver and index of fibrosis was found. 14 days after ligation the hepatocytes were isolated according to Seglen (7). The yield of hepatocytes isolated from the liver of cholestatic rats and from control animals was on average 4 x 10(8) cells with a viability of 80%. Ultrastructural the most hepatocytes showed intact organells without injury. We can conclude, that it is possible to isolate hepatocytes from chronic cholestatic rat livers with a good yield and viability as well as with an intact ultrastructure. These cells are suitable for additional metabolic investigations.

Animals↗
PubMedDate not supplied

[Blood PCDD/F levels in blood of residents of a former cable incineration facility].

Increased levels of polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofuranes (PCDF) were found in soil and roof dust of a residential area located near a metal reclamation plant in Northern Germany. In order to assess the degree of exposure of persons residing near to this plant, venous blood samples were collected from 14 subjects and analysed for PCDD/F and fat content. Furthermore, blood samples collected from the members of a farmer's family living nearby were analysed for PCDD/F. Previous studies had shown significantly increased PCDD/F levels in chicken eggs produced on this farm. Regarding the group of residents, the PCCD/F levels in blood fat were not increased when compared to background levels. However, some members of the farmer's family had increased PCDD/F levels in blood fat. The findings of these studies suggest that long-term consumption of contaminated animal products, especially chicken eggs, may result in increased PCDD/F levels in the body, whereas increased levels of PCDD/F in dust and soil do not noticeably affect the PCDD/F levels in human blood fat.

Adult↗