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S Hirosawa

Publications and source records attributed to S Hirosawa.

97 records · Page 6Linked to original sources
PubMed1983

Normalized natural killer (NK) cell activity in long-term remission of acute leukaemia.

NK cell activity was studied in 28 cases of acute leukaemia in remission. It was found that patients in long-term remission for 5 years or more had normal NK cell activity but those in remission for less than 5 years had significantly lowered activity. This suggests that patients with acute leukaemia had not been constitutionally deficient in NK cell activity. Low activity was augmented but not fully restored by interferon pretreatment in vitro. Therefore, the low NK cell activity observed during remission is not solely attributable to inadequate secretion of interferon in the host. It is suggested that the production of NK cells in bone marrow is impaired, or the function of NK cells is suppressed, by the leukaemia itself or by chemotherapeutic agents. Increased consumption of NK cells is also a possibility.

Acute Disease↗
PubMed1982

Malignant histiocytosis: a clinico-pathological study of three autopsied cases.

Clinicopathological features of three male cases with malignant histiocytosis (MH) are described. Case 1, aged 27, had had an indurated swelling of the left mandibular region, histologically being chronic lymphocytic inflammation, with ebb and flow for 4 years prior to the onset of MH, with low grade fever, lymphadenopathy and pulmonary infiltration. Histology of the lymph node was compatible with MH, and only a temporary improvement was obtained by COP therapy. Case 2, aged 32, showed acute febrile onset with severe anemia and splenomegaly. Diagnosis of MH was determined by bone marrow histology. COP therapy appeared effective, but caused severe leukopenia and thrombocytopenia resulting in fatal gastrointestinal bleeding. Case 3, aged 16, had high fever and cutaneous mass of the left chest wall, histology of which suggested MH. Bone marrow biopsy was also diagnostic. Severe pancytopenia allowed only a limited therapy. Morphology of the histiocytes was variable in each case. Diffuse infiltration of neoplastic histiocytes in many organs and erythrophagocytosis in the bone marrow were commonly found in all the cases. The present cases suggested a diagnostic value of bone marrow biopsy and possible effect of antineoplastic combination therapy on earlier stage of MH.

Adolescent↗
PubMedDate not supplied

Urinary procoagulant activity and tissue factor levels in patients with diabetes mellitus.

We characterized a factor important for the normal procoagulant activity in human urine and measured urinary tissue factor (TF) and thrombomodulin (TM) levels in patients with diabetes mellitus (DM). Urine shortened normal plasma-based clotting time, which is inhibited by antibody to the human TF. TF in urine presents in membrane-nonassociated and associated forms. The urine TF antigen levels in DM patients were significantly lower than those in healthy subjects, particularly in DM patients without retinopathy. Levels of TM in patients with DM and normal subjects were similar. Although urinary TF might be necessary to repair tissue injury of damaged sites in the excretory pathway of urine, the clinical relevance of the reduced TF in the urine needs further investigation.

Blood Coagulation↗