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Biomedical subjects

S Hiwatashi

Publications and source records attributed to S Hiwatashi.

11 recordsLinked to original sources
PubMed2001

Sarcoidosis associated with psoriasis vulgaris.

We report a 70-year-old patient with sarcoidosis associated with psoriasis vulgaris. He had a nodule on the medial lower lid of his right eye. Oral corticosteroid for the sarcoid lesions and oral PUVA for psoriasis were employed. The cutaneous lesion disappeared within two months after starting the therapy. No relapse of sarcoidosis has been seen for eight years. The association of sarcoidosis with psoriasis has been previously reported; however, it is still unclear whether this association coincidental or meaningful.

Aged↗
PubMed1998

[Studies on the conditions of blood sampling and storage for the liposome-based CH50 assay].

The CH50 values in the serum and plasma, especially those from chronic hepatitis caused by hepatitis C virus (HCV), are strongly affected and reduced through a process known as cold activation. We attempted to optimize the conditions of blood sampling and storage for the CH50 assay with a recently developed liposome-based assay kit. The bloods were obtained from HCV hepatitis patients as well as healthy donors. Regardless of the temperature (room temperature, 4 degrees C or 37 degrees C) at which samples were kept until the assay, higher values were always obtained in the serum than in the plasma. The plasma samples could either be heparinized or given any of the other anticoagulants, EDTA-2K and sodium citrate, at the time of sampling. We also attempted to optimize the temperature at which the fresh specimens were left during the period from sampling to assay and the temperatures to freeze them for storage and to thaw for assays. In the assays immediately after sampling, higher values were obtained when the specimens were left at 37 degrees C than at room temperature or 4 degrees C. To store at -80 degrees C rather than at -20 degrees C and to thaw rapidly at 37 degrees C rather than slowly at room temperature were found to be advantageous.

Blood Preservation↗
PubMed1996

Vitamin A is involved in estrogen-induced cell proliferation but not in cytodifferentiation of the chicken oviduct.

We examined vitamin A-deficient chicks to determine whether vitamin A affects the estrogen-induced development of the chick oviduct. When oviduct development was stimulated for 5 days with the synthetic estrogen, diethylstilbestrol, the wet weight of the oviduct in vitamin A-deficient chicks was only half that in control chicks. The DNA content in this tissue showed that the decreased oviduct weight in the vitamin A-deficient chicks was caused by the decreased proliferation of oviduct cells. However, the estrogen-induced expression of the ovalbumin gene was not affected by the vitamin A deficiency, suggesting that estrogen-induced cytodifferentiation is not affected by vitamin A. To clarify the vitamin A action on estrogen-induced development in the oviduct, transcripts of nuclear estrogen receptor (ER) and all-trans-retinoic acid (RAR alpha, beta and gamma) receptors, which exert the effects of estrogen and vitamin A, were measured. The ER, RAR alpha and RAR beta genes, but not that of RAR gamma, were expressed during oviduct development, indicating that estrogen and vitamin A may control the expression of target genes through their cognate receptors. Thus, we have shown that vitamin A is involved in estrogen-induced cell proliferation but not in cytodifferentiation of the chicken oviduct.

Animals↗
PubMed1981

Dissociation of the eyes in saccadic movement.

In horizontal saccades, abduction and adduction are not conjugate. Abduction starts shortly before adduction and reaches the turning point shortly after abduction. The duration in binocular recording is much shorter than in monocular recordings. The abducting eye has a tendency to move gradually on the new target. The adducting eye has, on the contrary, a tendency to overshoot. The characteristics of quick phases of horizontal optokinetic nystagmus, in which both eyes jump disconjugately to the new target, are similar to those of horizontal saccades. The main cause of this disparity may be a difference in neural mechanisms between abduction and adduction. Vertical saccades are not disconjugate.

Adult↗
PubMed1979

Optokinetic nystagmus in artificial hemianopsy.

Optokinetic nystagmus in cases of artificial hemianopsy was studied. Hemianopsy was produced by using a combination of a projector, an erasing device and DC ENG. The effect of the condition of foveal vision in hemianopsy, whether reserved or involved, was discussed. When foveal vision was reserved, nystagmus during stimulation in cases of hemianopsy was essentially the same as in the normal eye. In cases of hemianopsy in which foveal vision was involved, there was a remarkable difference between the mystagmus induced by foveofugal stimulation and that induced by foveopetal stimulation. In the former case the nystagmus was very fine and irregular, in spite of the fact that the nystagmus was well induced (it was nearly the same as in the normal eye in the latter case). Foveal vision is very important for the formation of the slow component of optokinetic nystagmus. Foveopetal movement of the image on the peripheral retina is very important for the formation of the quick component. Foveofugal movement on the peripheral retinal has, on the contrary, only a small effect in attracting the eye.

Eye Movements↗