Biomedical subjects

S Hollander

Publications and source records attributed to S Hollander.

2 recordsLinked to original sources

PubMed1990

The plateau in cytotoxic cancer drug discovery.

An examination of the history of cytotoxic cancer drugs development suggests that this activity is now on a plateau. It is striking that there have been no new chemotype cytotoxic anticancer drugs discovered in the past twenty years, despite the massive national effort in this area. It has been estimated that only 40 to 50% of patients currently diagnosed as having cancer will have a five year survival of the disease. This survival rate has been climbing at less than five percent per decade. Our conclusion is that a greater effort in biological response modification is warranted if we are to significantly affect the plateau.

Animals↗

PubMed1979

Recognition memory for typical and unusual faces.

In four studies, recognition memory for faces rated as similar to a prototype was found to be inferior to memory for faces rated as unusual in appearance. This result was obtained under both incidental and intentional learning conditions, at presentation rates ranging from 3 to 15 sec, and with retention intervals from 3 to 24 hr. A fifth experiment established interitem similarity as the structural basis of this typicality effect in recognition memory. Difficulties in interpreting the findings in terms of some current models for classification learning, depth of processing models, or present models of the word frequency effect are discussed.

Attention↗