Biomedical subjects

S Holm-Jensen

Publications and source records attributed to S Holm-Jensen.

5 recordsLinked to original sources

PubMed1979

The significance of the target frequency and the target speed in optokinetic nystagmus (OKN).

The significance of the frequency of the stimuli (target frequency) and the angular velocity of the stimuli (target speed) on horizontal optokinetic nystagmus (OKN) was investigated in 6 normal human subjects using target frequencies from 1/3 Hz to 24 Hz and target speeds from 5 degrees/sec to 120 degrees/sec. Regularity and reproductiveness of the OKN were obtained only in test conditions where each transit of targets was followed by an optokinetic response either as one beat or as a sequence of beats. This is called synchronous response and was found when the target frequency was below 3 Hz and the target speeds below 20--30 degrees/sec, depending on the actual frequency. At higher target frequencies and target speeds, the eyes were unable to take up every target, resulting in uneven responses (hyposynchronous response). Very low target frequencies and target speeds were likewise unsuitable due to drifting of the eyes from one target to another. A target frequency and a target speed close to the upper limit for synchronous response is advocated in clinical tests of OKN. 2 Hz and 20 degrees/sec is proposed as a suitable combination of frequency and target speed.

Adolescent↗

PubMed1976

[Ototoxic agents].

Explore the source record for details and available documents.

Aminoglycosides↗

PubMedDate not supplied

Oncocytic cysts of the larynx.

Oncocytic cysts make up a pathologically well-defined sub-group of cystic lesions in the larynx. As a rule they originate from the ventricle and occur in middle-aged or elderly persons. Clinically these tumours are uncharacteristic. Such oncocytic cysts are interpretable as retention cysts rather than actual new growths. The question concerning their rare occurrence is discussed on the basis of 5 cases diagnosed within a period of 2 months.

Aged↗

PubMedDate not supplied

Nasopharyngeal bacteriology and secretory otitis media in young children.

A prevalence study was performed on the nasopharyngeal bacteriology of 112 young children, aged 4-6 years. During the preceding 2 years, 74 of these children had suffered from secretory otitis media (SOM) and 40 had had normal middle ear ventilation. At the examination, one-third of the children with SOM had improved their middle ear status (previous SOM group), whereas otomicroscopy and tympanometry remained unchanged in the healthy group. The nasopharyngeal swab sample was obtained from behind the soft palate by the oral route. The isolation rate of Streptococcus pneumoniae was significantly higher in the SOM group than in the two other groups of children (p less than 0.006). The most commonly isolated capsular types of pneumococci were 6, 19, and 23, corresponding to the types involved in acute otitis media. The isolation rate of Haemophilus influenzae was 50% and an even distribution was found among the three groups of children examined. Biotypes I, II, III and IV accounted for 75% of the isolated cases of H. influenzae. As in acute otitis media, S. pneumoniae also seemed to play an important role in the pathogenesis of tubal dysfunction and SOM, and the difference is probably caused by variations in the quantitative colonization of pneumococci in the nasopharynx.

Child, Preschool↗

PubMedDate not supplied

Dominantly inherited low-frequency hearing loss.

Two families with dominantly inherited low-frequency hearing loss are described. The two families are different in mode of transmission and in audiological findings. On the basis of these two differences, it is claimed that two types of inherited low-frequency hearing loss can be distinguished. One type is the dominantly inherited low-frequency hearing loss with fully penetrant abnormal genes. The other is also most probably due to an autosomal dominant gene, but with incomplete penetrance and probably represents a malformation in the middle ear combined with a defect in the apical part of the cochlear mechanism.

Audiometry↗