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Biomedical subjects

S Homatidis

Publications and source records attributed to S Homatidis.

16 recordsLinked to original sources
PubMed1999

Chromosomal abnormalities in a series of children with autistic disorder.

In a series of 127 children diagnosed with autistic disorder the karyotypes of 8, on whom data were available, showed the following chromosomal abnormalities: breakage, a 47 XY pattern, trisomy 13, inversion-duplication of chromosome 15, 47 XY, +der (15) (pter q15: p11 pter), 47 XXY and 46 XY, inv (2) (p11:q13pat, 3q+). Compared to those who were not karyotyped or had normal karyotypes, the children with abnormalities, although cognitively more delayed, were not rated as more severely autistic. Facial dysmorphias and minor physical anomalies tended to be more frequent in the chromosomally deviant subgroup. No differences in demographic characteristics or parental ages were evident. Results are consistent with the view of variability of expression of marker chromosome deviations and a greater severity of retardation and symptoms of autism in those affected. The relevance of the findings to a multimodal genetic etiology of autistic disorder is discussed.

Autistic Disorder↗
PubMed1992

Assessing resources and stress in parents of severely dysfunctional children through the Clarke modification of Holroyd's Questionnaire on Resources and Stress.

The Holroyd (1974) Questionnaire on Resources and Stress (QRS) although clinically useful may be too inclusive and not exclusively relevant to severely dysfunctional individuals. Hitherto, efforts at shortening and psychometrically validating the QRS have met with some success: the shorter forms however still target both mentally and physically handicapped children and are clinically not as useful as the original instrument. The 78-item Clarke modification of the QRS, mainly a subset of the original, was an attempt to remedy these problems. It was validated with mothers and fathers of autistic, mentally retarded, learning-disabled, and asymptomatic children. Good internal consistency, split-half reliability, and coefficient of stability were obtained. Construct and concurrent validities were also acceptable. The questionnaire discriminated best between the two more severely affected groups and the controls. Group differences were found for 8 of its 9 scales and sex of parent differences were found for 3. The Clarke modification of the QRS is recommended for clinical use with parents of children with autism and mental retardation.

Activities of Daily Living↗
PubMed1991

Effects of developmental disorder on parents: theoretical and applied considerations.

Only recently have we begun to examine systematically the effect of dysfunctional children on other family members. This article addresses several issues: (1) It presents two models of family stress, the ABCX and the social ecology model, and discusses how they can be employed for a systematic mapping of known key variables that, in complex interplay, appear to influence the family's ability to cope with a dysfunctional child. (2) It reviews evidence from our own work and research by others related to the main elements of the ABCX model of family stress. (3) It offers an outline of what appear to us to be the key methodologic considerations for improving quality of research in this area. (4) It provides a few recommendations to clinicians working with families of severely dysfunctional children based on the evidence and our clinical experience.

Adaptation, Psychological↗
PubMed1989

Parental perception of learning-disabled children's adjustment problems and related stress.

Mothers and fathers of learning-disabled (LD) children rated their children's problems on the Child Behavior Checklist (CBCL) and the stress they experienced as a result of each problem. Data were examined as a function of (a) the child's sex, age, birth order, IQ, discrepancy IQ, and degree of LD, (b) the parents' age, locus of control, and self-concept, and (c) family SES, family size, and mother's working status. Both parents rated externalizing behaviors higher than internalizing. Boys were rated as significantly more problematic and stressful than girls. Greater child adjustment problems and concomitant parental stress were reported by the younger half of the maternal sample and their spouses, and by fathers with a lower self-concept and their wives. Although mothers did not differ from fathers in behavior ratings, they reported greater stress in response to them. This was particularly true of mothers of middle or upper SES with an external locus of control.

Adaptation, Psychological↗
PubMed1989

Assessing child symptom severity and stress in parents of autistic children.

Parents of 44 autistic children rated their children's symptom severity and their own stress on a 14-item symptom scale. Thirteen child and family characteristics were also examined to assess how they affected symptom perception and stress. Preschoolers were rated less symptomatic by their parents than by clinicians. Lower functioning, nonverbal, odd-looking, self-abusive, seizuring and hyperirritable children were rated more symptomatic than their peers. Best predictor of stress for both parents was a child's self-abuse; for mothers hyperirritability and older age were also associated with elevated stress scores. Compared with parents of matched normal children, mothers of autistic children reported the most aggravations and expressed the need for additional support from their spouses.

Adaptation, Psychological↗
PubMed1988

Maternal speech to verbal and higher functioning versus nonverbal and lower functioning autistic children.

The relationship between autistic children's level of functioning and maternal speech to children was examined. Ten higher functioning verbal and 10 lower functioning nonverbal children were videotaped in a 15-minute interaction with their mothers. Results revealed that mothers of the higher functioning verbal children asked more questions, used more language modeling, gave more reinforcement for language, and answered more children-initiated questions than did mothers of the lower functioning nonverbal children. Mothers of the nonverbal children employed more directives, used shorter mean lengths of utterance, and reinforced their children's motoric rather than spoken behavior. Far from being poor models for linguistic behavior, mothers of autistic children appear, therefore, to be quite responsive to their children's relative capabilities.

Autistic Disorder↗
PubMed1987

Ear infections in autistic and normal children.

The frequency of ear infections, ear tube drainage, and deafness was examined through parental reports in autistic and yoke-matched, normal children. For the autistic group these difficulties were additionally examined as a function of the children's cognitive and communication abilities, verbal versus nonverbal status, sex, and degree of autistic symptomatology. Autistic children had a greater incidence of ear infections than matched normal peers. Lower-functioning children had an earlier onset of ear infections than their higher-functioning autistic peers. Ear infections coexisted with low-set ears, and with a higher autistic symptomatology score. The findings are discussed in terms of greater CNS vulnerability in the autistic children, which is likely present since embryogenesis. The possible adverse consequences of intermittent hearing loss on language, cognitive, and socioaffective development are considered.

Adolescent↗
PubMed1985

Dominance hierarchies in normal and conduct-disordered children.

Two groups of conduct-disordered children in day treatment and two groups of normal matched controls were observed over eight sessions in a free-play situation. The purpose of the study was to examine whether disturbed children formed dominance hierarchies, and to compare the power relations among disturbed children to those of normal peers. Results indicated that the hospitalized children did form dominance hierarchies, although their hierarchies were not as stable as those of their normal peers. Moreover, an inverse relation was noted between intragroup conflict and the hierarchy's stability. In addition, the pattern of targeting differed between the normal and disturbed youngsters. Conflict among the children in both control groups tended to be concentrated among members of adjacent ranks. The disturbed children, on the other hand, were less discriminating as to their target's rank, exhibited greater intragroup conflict, and lost more frequently in their agonistic encounters.

Agonistic Behavior↗
PubMed1984

Aggressive and prosocial behaviours before and after treatment in conduct-disordered children and in matched controls.

Aggressive and prosocial behaviours and responses to prosocial acts were examined in groups of conduct-disordered and normal children. The observations were repeated following therapeutic intervention. Before treatment, the clinic groups displayed greater levels of peer-directed aggression and responded inappropriately to social overtures. Following intervention, both clinic groups showed improved responsiveness to their peers' social overtures and the older clinic children reduced their aggression while the younger children did not. Independent evaluations of each child's medical file and case disposition revealed that the observational data served as a sensitive index of the status of the two clinic groups.

Aggression↗
PubMed1983

Effectiveness of cognitive mediation and behaviour modification with hospitalized hyperactives.

This study examined the efficacy of behaviour modification and cognitive mediation in treating two groups of hyperactive boys in day treatment. The study marks a departure from other research in two main areas: a) the severity of the children's symptomatology was such that it necessitated their removal from school; b) the interventions employed were intensive and of long duration (10 months), as opposed to the brief, short-term efforts commonly reported. Multiple outcome measures were employed to assess the effectiveness of each of the behavioural treatments. The children were administered a battery of tests shortly after their admission and again prior to discharge, 10 months later. Six main areas, considered relevant to the syndrome of hyperactivity, were tapped. These were: impulsivity, motor activity, sustained attention, self-concept, field-dependence/independence, and an overall hyperactivity rating independently assessed by a clinician. Results indicated that the two groups of children made comparable gains in each of the main areas studied. Moreover, the children of both groups were considered sufficiently improved by their clinical team to be discharged back to the regular school system.

Attention↗
PubMed1982

Gait patterns of depressed patients and normal subjects.

The authors compared the gait patterns of 15 patients with affective disorders with those of 15 normal control subjects. The procedure involved a frame-by-frame analysis of a film of each subject walking at normal speed. Angle measurements were made of the hip and knee at their maximum extension during a single gait cycle (one stride). The results generally support the hypothesis that depressed patients walk with a lifting motion of the leg, whereas normal control subjects propel themselves forward.

Adolescent↗
PubMed1975

Sensorimotor and physiological effects of various alcoholic beverages.

Effects of a standard dose of alcohol (1.3 g/kg) in the form of Canadian rye whisky, Canadian beer and a sparkling table wine were compared with those of a nonalcoholic carbonated control beverage. Sixteen young male and eight female subjects, all moderate drinkers, were tested in a Latin square design. Measurements were made on the pursuit rotor and quantitative Romberg tests, and of skin temperature, heart rate, malar flush and blood alcohol concentration during the prealcohol baseline period and at regular intervals over the 4-hour drinking period. The three alcoholic beverages produced blood alcohol curves that did not differ significantly. All three alcoholic beverages produced increasing sensorimotor impairment over time, which corresponded in degree to the increasing blood alcohol concentration. There were no significant differences between the three beverages on either the sensorimotor or physiological measures at any blood alcohol value. The results of this study indicate that the degree of impairment after alcohol ingestion in a socially relevant manner is not dependent on the type of beverage consumed, but only on the resulting blood alcohol concentration.

Adult↗