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Biomedical subjects

S Hosaka

Publications and source records attributed to S Hosaka.

At least 19 recordsLinked to original sources
PubMed1995

Growth-related gene product alpha. A chemotactic cytokine for neutrophils in rheumatoid arthritis.

Leukocyte recruitment is critical in the inflammation seen in rheumatoid arthritis (RA). To determine whether the chemokine growth-related gene product alpha (gro alpha) plays a role in this process, we examined synovial tissue (ST), synovial fluid (SF), and plasma samples from 102 patients with arthritis. RA SF contained more antigenic gro alpha (mean 5.3 +/- 1.9 ng/ml) than did SFs from either osteoarthritis (OA) or other forms of arthritis (mean 0.1 ng/ml) (p < 0.05). RA plasma contained more gro alpha (mean 4.3 +/- 1.8 ng/ml) than normal plasma (mean 0.1 ng/ml) (p < 0.05). RA ST fibroblasts (1.2 x 10(5)/cells/mI RPMI 1640/24 h) produced antigenic gro alpha (mean 0.2 +/- 0.1 ng/ml), and this production was increased significantly upon incubation with TNF-alpha (mean 1.3 +/- 0.3 ng/ml) or IL-1 beta (mean 2.3 +/- 0.6 ng/ml) (p < 0.05). Cells from RA SF also produced gro alpha: neutrophils (PMNs) (10(7) cells/mI/24 h) produced 3.7 +/- 0.7 ng/ml. RA SF mononuclear cells produced gro alpha, particularly upon incubation with LPS or PHA. Immunoreactive ST gro alpha was found in greater numbers of RA compared with either OA or normal lining cells, as well as in RA compared with OA subsynovial macrophages (p < 0.05). IL-8 accounted for a mean of 36% of the RA SF chemotactic activity for PMNs, while epithelial neutrophil-activating peptide-78 accounted for 34%, and gro alpha for 28%, of this activity. Combined neutralization of all three chemokines in RA SFs resulted in a mean decrease of 50% of the chemotactic activity for PMNs present in the RA SFs. These results indicate that gro alpha plays an important role in the ingress of PMNs into the RA joint.

Arthritis, Rheumatoid↗
PubMed1995

[Aortic valve replacement for rheumatoid aortic valve regurgitation].

Valve replacement for aortic regurgitation in patient with rheumatoid arthritis was rare in Japan. We report a successful case in which aortic regurgitation necessitated aortic valve replacement. A 62-year-old woman was admitted for shortness of breath, chest pain and progressive edema. She had been treated for rheumatoid arthritis for more than ten years using steroids. The aortic valve was successfully replaced by a prosthetic mechanical valve. The histopathological examination of the excised aortic valve demonstrated rheumatic nodules in the right- and non-coronary cusp. It was supported that these changes caused shrinkage of cusp and resulted in aortic regurgitation. This patient was discharged on the 20th postoperative day. There was no evidence of detachment of the prosthetic valve.

Anti-Bacterial Agents↗
PubMed1995

[Treatment of acute type A aortic dissection with onset of the right coronary insufficiency].

This is a case report of the successful treatment for acute type A aortic dissection with onset of the right coronary artery (RCA) obstruction due to compression of the dissected lumen. A 50-year-old man, who had been received medical therapy for hypertension for seven years, was admitted with profound cardiogenic shock. The ECG demonstrated complete A-V block and acute myocardial infarction (AMI) of right ventricle and inferior wall. Coronary catheter intervention was scheduled because intra-aortic balloon pumping was not effective, and arteriogram revealed aortic dissection, coronary insufficiency and aortic regurgitation (grade I). Soon after inflation of a perfusion catheter at the origin of RCA, elevation of arterial blood pressure and recovery to sinus rhythm were brought successfully by the coronary reperefusion. Replacement of the ascending aorta involving the intimal tear without surgical closure of RCA ostium, aortic valve resuspension and coronary artery bypass grafting with saphenous vein to RCA were performed 11 hours after the onset, and the postoperative course was uneventful. Although aortic dissection with onset of AMI was uncommon, it is suspected that the generalizing of catheter intervention for AMI increases awareness of such cases and it is emphasised that the application of perfusion catheter as an emergency procedure for the illness like this case is useful to preserve hemodinamic stability until the surgical treatment.

Aortic Dissection↗
PubMed1995

[A case of mitral regurgitation due to partial papillary muscle rupture whose etiology was unknown].

The etiology of the papillary muscle rupture includes myocardial infarction, trauma, hypertension, myxomatous degeneration, endocarditis etc. We report a case of partial papillary muscle rupture whose etiology was unknown, in a 77-year-old woman. The preoperative catheterization and coronary angiography showed severe mitral regurgitation and no significant coronary stenosis. And we recognized the mass waving into the left atrium in systole with the echocardiogram. At surgery, we repaired the mitral valve by resecting quadrangular areas of the posterior leaflet including the attachment of the torn papillary muscle. Additionally a number 28 Carpentier-Edwards mitral annuloplasty ring was sewn in place. In pathologic specimen, there were focal fibrosis, necrotic muscle, lymphocytes, and no vegetation.

Aged↗
PubMed1994

Expression of the chemokine superfamily in rheumatoid arthritis.

The infiltration of leucocytes into the joint of rheumatoid arthritis (RA) is believed to be mediated by chemotactic factors released by activated cells. In this study, examination was made of the gene expression and production of the chemokine superfamily in RA patients by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunoprecipitation. Cultured synovial fibroblasts were found capable of expressing and producing IL-8, GRO, monocyte chemotactic and activating factor (MCAF), macrophage inflammatory protein-1 alpha (MIP-1 alpha), MIP-1 beta and RANTES in response to IL-1 alpha. The expression of IL-8, GRO, MCAF, MIP-1 alpha, and MIP-1 beta was clearly shown to increase in freshly isolated synovial fluid mononuclear cells (SFMC) of RA patients, in contrast to peripheral blood mononuclear cells (PBMC) of RA patients and normal subjects. The gene expression of RANTES appeared to be the same for RA SFMC, RA PBMC, and normal PBMC. Thus, the over-expression of various chemokines may promote the recruitment of inflammatory cells into rheumatoid inflamed joints.

Arthritis, Rheumatoid↗
PubMed1994

Cutaneous vasculitis in a patient with dermatomyositis without muscle involvement.

A 74-year-old female patient with cutaneous ulcerations and typical dermatomyositis (DM) skin rash had no muscle disease for a 1-year and 5 months period. Histological examination of the skin ulceration indicated vascular occlusion without cellular infiltration. Cutaneous ulceration is a very rare manifestation of adult-onset DM patients without inflammatory myopathy.

Aged↗
PubMed1994

[Intrabronchial neurilemmoma: a case report].

A 62-year-old woman who was pointed out abnormal shadow at left middle lung field in chest X-ray was followed up as a hamartoma from 1989. In this period, the tumor was growing up in chest X-ray and occupying the left segmental bronchus (B3) in bronchofiberscopic study. It was suspected neurilemmoma by the final biopsy examination. Left upper lobectomy was performed and pathohistological diagnosis was typical neurilemmoma that consist of Antoni type A and Antoni type B. Intrapulmonary or intrabronchial neurilemmoma is rare and only 20 cases have been reported in the Japanese literature.

Bronchial Neoplasms↗
PubMed1992

Adult Still's disease with myocarditis and peritonitis.

A 26-year-old woman had myocarditis and peritonitis during an acute multisystem attack of Still's disease. To our knowledge, these complications are rare manifestations of adult Still's disease. Treatment with high-dose adrenocorticosteroids was rapidly successful in controlling these manifestations.

Adult↗
PubMed1992

[Chest wall reconstruction with a prosthetic material molded from a extirpated specimen].

A new molding technique of the Acryl-resin Marlex-mesh sandwich method is described. After the wide extirpation of the chest wall, the defect size tends to grow up more larger than the specimen. For making a just fit size prosthesis, we cut off a cardboard as the same size as the specimen and the Acryl-resin Marlex sandwich is molded from the cardboard. Other some know-how are in the text.

Acrylic Resins↗
PubMed1991

Follicle-like hemicysts reorganized in monolayer culture of rat thyroid cells in the medium supplemented with isologous serum.

Monolayer culture of the cells isolated from rat thyroid glands formed a number of large and three-dimensional (about 200-microns diameter) hemicysts in media supplemented with isologous and high-concentration serum. The higher was the concentration of isologous serum, the larger was the hemicysts and the higher was the uptake of 131I of hemicysts. Substitution of heterologous serum, such as calf or fetal calf serum, for the isologous serum failed to form hemicysts.

Animals↗
PubMed1991

Dynamic movement of hemicysts reconstructed from monolayer cultures of rat thyroid cells in isologous serum.

Time-lapse studies using cine-microscopic observation showed that the hemicysts formed in a culture of rat thyroid cells in a high concentration of isologous serum were found to arise by swelling from the monolayer sheet, gradually increase in size, and then rapidly collapse. The hemicyst volume increased linearly. We speculate that each hemicyst epithelium transport a constant volume of liquid into the hemicyst lumen.

Animals↗
PubMed1991

[Nonocclusive intestinal necrosis after the successful veno-arterial bypass].

A 52-year-old male suffered from acute viral myocarditis with severe cardiogenic shock. On his admission, he underwent the inotropic and IABP supports, and subsequently was treated effectively by V-A bypass, which was continued for 35 hours. But he died in the period of 69 hours after V-A bypass from extended bowel necrosis and septic shock. The small and large intestinal mucosal necrosis, hemorrhagic hepatic necrosis and acute tubular necrosis were confirmed at necropsy. It is well known that the nonocclusive mesenteric vascular spasm is concerned strongly in their pathogenesis, after prolonged severe cardiogenic shock.

Acute Disease↗
PubMed1991

[A case of Morgagni's hernia: availability of CT scan, ultrasonography, and trans-abdominal surgical approach].

A 60-year-old obese woman was admitted to our hospital to receive surgical treatment for "slow-growing mediastinal lipoma". With the non-invasive examination such as CT scan and ultrasonography, she was revealed as Morgagni's hernia containing a greater omentum. With a trans-abdominal approach, we could take a good surgical field for the bilateral foramina of Morgagni. Several discussions were described for availability of CT scan, ultrasonography and a trans-abdominal approach.

Diagnosis, Differential↗
PubMed1988

Effect of neutrophil activating substances on intracellular generation of phagocyte chemiluminescence by means of luminol-bound microspheres.

The intracellular chemiluminescence of granulocytes was measured by luminol-bound microspheres. After one minute of incubation, which was necessary for the granulocytes to phagocytize microspheres, intracellular chemiluminescence was generated. The intracellular chemiluminescence was enhanced by the introduction of granulocyte stimuli including concanavalin A, phorbol-myristate acetate, and formyl peptides. This incremental effect was the result of certain metabolic changes inside the cells. This newly discovered chemiluminescent reagent promises to be a useful tool for examining metabolic changes inside phagocytic cells.

Concanavalin A↗