Biomedical subjects

S Hseuh

Publications and source records attributed to S Hseuh.

3 recordsLinked to original sources

PubMed1995

Pulmonary tuberculosis as a source of infection after total hip arthroplasty. A report of two cases.

Two cases of septic loosening due to a tuberculosis infection occurred 18 months and 14 years after total hip arthroplasties. The primary source was pulmonary tuberculosis. Treatment was by removal of the prosthesis and radical debridement with the local implantation of gentamicin PMMA beads, followed by antituberculosis chemotherapy for one year. In the first case, a revision arthroplasty was carried out 20 months later; the second was reconstructed with a vastus lateralis transposition one month later. There was no recurrence of infection after a follow up of 3 and 2 years respectively. Although this is a rare complication, the possibility must be born in mind. Early diagnosis and treatment of pulmonary tuberculosis may prevent the secondary infection of a total hip arthroplasty.

Adult↗

PubMed1987

Cutaneous protothecosis. A clinicopathologic study.

In what we believe to be the first case of cutaneous protothecosis identified in Taiwan, a 5-year-old Chinese girl presented with a pruritic erythematous plaque on her right upper eyelid. A clinical diagnosis of eczematous dermatitis was made initially, and sporotrichosis was diagnosed subsequently. Later, histopathologic and cultural studies of the lesion finally led to the diagnosis of protothecosis. The recognition of the characteristic sporangia containing symmetrically arranged endospores is the most important initial diagnostic clue of protothecosis. Biochemical assimilation tests and direct immunofluorescence study using species-specific antibodies identified the organism as Prototheca wickerhamii. Systemic ketoconazole treatment proved to be effective for our patient. The in vitro minimal inhibitory concentrations of tetracycline hydrochloride, amphotericin B, and ketoconazole were also determined.

Biopsy↗

PubMedDate not supplied

Preliminary tear film measurements of tolerant and non-tolerant contact lens wearers.

BACKGROUND: The relationship between contact lens intolerance and tear stability, tear quantity, distribution and consistency has yet to be clearly established. In this study, we have examined the tear film of several tolerant and non-tolerant soft contact lens wearers. We aimed to develop a number of clinical and biochemical techniques to establish a correlation between one or more factors leading to contact lens intolerance. METHODS: Subjects were separated by their self-described tolerance to contact lens wear. Five tolerant and five non-tolerant subjects were chosen. A McMonnies symptomatology questionnaire was used to ascertain subject history, while non-invasive tear break-up time (TBUT) examined tear stability. Basal tear collection was performed using glass capillary tubes, the tear flow rate was measured and one dimensional gel electrophoresis used to analyse protein differences. RESULTS: Non-tolerant subjects experienced primary symptoms, such as dryness and grittiness, more often than tolerant subjects (p = 0.007). The TBUT of non-tolerant lens wearers was also reduced (average of seven seconds) compared to tolerant lens wearers (p < 0.002). Tolerant lens wearers had a longer more stable tear film with an average TBUT of 20 seconds and this correlated with a fast tear flow rate (p < 0.04). Protein gel electrophoresis showed that some subjects who were non-tolerant to lens wear had variations in their tear protein profiles compared to tolerant subjects. CONCLUSION: These preliminary results demonstrate that clinical and biochemical tear profiles can be used to differentiate subjects with good lens wear tolerance from those who may be non-tolerant to lens wear.

Journal Article↗