PubMed Health⌕ Search

Biomedical subjects

S Huether

Publications and source records attributed to S Huether.

5 recordsLinked to original sources
PubMed1989

Cutaneous blood flow and percutaneous absorption: a quantitative analysis using a laser Doppler velocimeter and a blood flow meter.

Cutaneous blood flow has been directly quantitated in vivo for the first time without animal death utilizing the rat skin sandwich flap. This was accomplished by conducting experiments that made a direct correlation between two instruments: a laser Doppler velocimeter and an electromagnetic blood flow meter. Data demonstrate that the correlation between these two instruments is high and reproducible (r = 0.96) with a small (1.3%) coefficient of variation. Blood flow to skin in the unmanipulated state varies from 0.7 to 1.2 mls/min in an anesthetized rat. Application of the blood flow correlation to the determination of percutaneous absorption of caffeine across human skin and benzoic acid across rat skin demonstrates that assuming cutaneous blood flow is a particular value day to day in any skin type results in an apparent wide range of total compound absorbed across that skin on independent occasions. Utilizing actual blood flow measurements to calculate the amount of chemical absorbed reduces the range of variability in the total amount of chemical absorbed and provides a more accurate knowledge of events occurring during a particular time of the absorption process. Quantitation of cutaneous blood flow will be useful in physiologic and pharmacologic studies where actual cutaneous blood flow is likely to be important to the processes studied, e.g., delivery of drug to skin, metabolism within the skin, and disposition of drug to blood and skin following topical drug application.

Animals↗
PubMed1987

An experimental skin sandwich flap on an independent vascular supply for the study of percutaneous absorption.

Further insights into the composite interactive processes of topically applied agents and percutaneous absorption and metabolism by functional skin in vivo have been hampered by the lack of a model system wherein the blood flow to and from the skin is independent but experimentally accessible. Utilizing microsurgical techniques, split-thickness skin grafting with syngeneic skin grafts, and the congenitally athymic (nude) rat, a skin sandwich flap system has been generated that has an independent but accessible vasculature and thus fills this void. We describe the methodology that has been developed to create the flap and present experiments that: demonstrate a lack of significant collateral circulation; quantify the microcirculation of the skin sandwich flap, host side, and graft side at various times during and after the flap has been generated, and note that blood flow to the flap is basically unchanged from host skin; demonstrate the utility of the system in measuring the amount of [14C]benzoic acid that appears in the flap when deposited on the surface in volatile and nonvolatile vehicles as a function of time; and demonstrate the fact that the flap can be reused, and that the total amount of [14C]benzoic acid absorbed across skin does not change in a substantial way as the flap ages.

Animals↗
PubMed1984

Hypertrophic scarring in argon laser treatment of port-wine stains.

The argon laser (488 to 514 nm) is being used with increasing frequency in the treatment of port-wine stains (PWS). Good results are reported, but scarring is a major complication in all series. The purpose of this paper is to describe the incidence and extent of scarring in a more definitive fashion by quantitating this complication in terms of size, elevation, and color in a consecutive series of 146 patients followed for over 1 year. Scars were assigned a severity score of 1 through 5. A midstudy evaluation led to a significant change in treatment methodology. Therefore, the patient population was divided into two groups. Group I consisted of the first 73 patients and included 30 males and 43 females with an age range of 7 to 81 years (M = 35 years). Group II consisted of the next 73 consecutive patients and included 24 males and 49 females with an age range of 12 to 75 years (M = 43 years). Group II received a different treatment technique than group I. In group I the incidence of scarring was 38 percent for patients under 12 years and 21 percent for patients over 12 years. In group II the incidence was 13.7 percent with concomitant reduction in severity. Statistical analysis (M- HX2 ) compared group I children and adults, P = 0.36; children and group II adults, P = 0.08; group I adults and group II adults, P = 0.42. The most frequent and severe scarring occurred on the upper lip and central portion of the face. Individualization of energy fluency and attention to unique patient factors in healing are important in improving results.

Adolescent↗
PubMedDate not supplied

Description of a graduate program in clinical nursing informatics.

This article describes the history and development of the Clinical Nursing Informatics Program at the University of Utah College of Nursing. Program philosophy and curriculum are discussed in the context of the conceptual framework. Courses and student projects are described. The authors reflect on the ensuing stage of program development.

Computer Systems↗