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Biomedical subjects

S Hugon

Publications and source records attributed to S Hugon.

8 recordsLinked to original sources
PubMed1999

Mutation at codon 210 (V210I) of the prion protein gene in a North African patient with Creutzfeldt-Jakob disease.

A point mutation at codon 210 of the prion protein gene (PRNP), resulting in the substitution of isoleucine for valine (V210I) has been found in a 54-year-old Moroccan patient affected with Creutzfeldt-Jakob disease (CJD). This patient is the first carrier of the PRNP V210I mutation reported from North Africa. The clinical presentation of the patient was rather similar to that seen in classical CJD, except that unusual early sensory symptoms were observed. The mother of the proband, aged 72, is a further example of an asymptomatic elderly carrier of the PRNP V210I mutation, suggesting an incomplete penetrance of the disease.

Amino Acid Substitution↗
PubMed1991

[A nicardipine-isoflurane combination in the microsurgery of the middle ear].

Middle ear microsurgery requires a bloodless operative field, achieved through deliberate hypotension techniques. The present work was designed to analyze the quality of the deliberate hypotension induced by the combination of isoflurane with nicardipine, an injectable calcium channel blocker. Eleven patients, ASA I, 10 minutes after induction of anaesthesia, received nicardipine as a bolus of 25 mg renewed every five minutes (maximum 4) and as a perfusion (5 mg/hour). The bloodless operative field was excellent in all cases with a 29.7% drop in arterial blood pressure after 15 minutes (heart rate: +22.3% after 25 min); values then remained stable until nicardipine was stopped; then hemodynamic data returned to the preanaesthetic values in 66 +/- 56 minutes. No side effect was registered. As a conclusion, deliberate hypotension induced by isoflurane--nicardipine combination provides good conditions for middle ear microsurgery.

Adult↗
PubMed1984

[Hemodynamic interferences between diltiazem and thiopental--experimental study in the pig].

The clinical applications of calcium channel blockers are rapidly growing; as barbiturates interfere with intracellular calcium movements, the possibility of drug interaction at this level must be considered. We have studied the haemodynamic interaction of Thiopentone and Diltiazem in pigs. A loading dose of Diltiazem (0.15 mg X kg-1) was injected followed by a continuous administration of 0.07 mg X kg-1 X hour. From the fifth to the tenth minute, the reduced afterload was associated with a moderate depression of the contractility of the left ventricle. These values returned to the initial level within 30 minutes. Heart rate and cardiac output were not modified. The stability of these two parameters is thought to result from the complex interaction of both drugs on the sympathetic nervous system and the ventricular function.

Animals↗
PubMed1984

[Anesthesia in surgery of Basedow's disease].

Adequate preparation for surgery can be achieved in patients with Grave's disease by a combination anti-thyroid medication, Lugol's solution and beta-blockers, mainly propranolol. Only in rare cases when this treatment had failed has plasmapheresis been used. No thyroid storm occurred in the 35 cases reported. Should this complication be encountered, plasmapheresis appears to be the treatment of choice.

Adrenergic beta-Antagonists↗
PubMed1982

[Peridural analgesia with high doses of fentanyl: failure of the method for early postoperative kinesitherapy in knee surgery].

Following orthopedic surgery of the lower limb, ten patients were given fentanyl 5 micrograms . kg-1 in a single epidural injection. Almost complete analgesia (P less than 0.001) was rapidly obtained. The total period of analgesia was rather short (182.3 +/- 32.1 min). The maximal analgesia period was 87 +/- 8.34 minutes. Despite this high dose of fentanyl (245 to 450 micrograms), in five patients the passive mobilization of the knee following surgery was extremely painful and, for that matter, impossible in three of them. Such high doses of fentanyl entail the risk of respiratory depression as respiratory rate is decreased (P less than 0.01) and the Pco2 is increased (P less than 0.01). Fentanyl should not be used at such high dosage and should probably not be preferred to morphine, considering that the duration of analgesia is short, that the analgesic score is identical to that obtained with lower doses or with longer lasting narcotics, that it does not prevent passive mobilization pains and that it entails a definite risk of respiratory depression.

Adult↗
PubMed1981

[Actuality of ambulatory anaesthesia in oto-rhino-laryngologic surgery (author's transl)].

The ambulatory intervention in ORL surgery presents a certain amount of constraint : anaesthetic, surgical, medicolegal and socio-economic. In spite of the lack of medicolegal definition for ambulatory anaesthesia, these anaesthetic intervention may take place in conditions approaching the other anaesthetic intervention provided that some rules are respected. The authors propose a practical treaty for the ambulatory intervention ORL surgery and as an illustration to this presentation propose a sample of a hundred ambulatory interventions.

Ambulatory Surgical Procedures↗