Biomedical subjects
Publications and source records attributed to S I Dokumov.
Pregnancy, aggravated by hyperprolactinaemic empty sella syndrome, is a risky and rare event. A case with such complication and continuous bromocriptine treatment during the whole gestation is presented. Neither fetal abnormalities nor deterioration of maternal pituitary pathology or the course of gestation are observed.
Specialized sensory perception was examined in 20 women with polycystic ovary syndrome and in 20 healthy women with normal ovulatory genital cycle. None of the healthy women disclosed any anomaly in sensory perception while with no exception all patients with polycystic ovary syndrome disclosed anomalies in sensory perception of one or other sensory analyzer. Defects in smell (hypoosmis) were more common (19 cases) than those of taste (hypogeusia) (II cases), of vestibular (14 cases) or auditory (3 cases) function, although defects in two or more analyzers occurred together in most of the cases. The association of the syndrome with anomalies in the sensory perception suggested that various central nervous structures beside these controlling the releasing factors are involved in the pathomechanism of the disease and that specialized sensory perception in man has much more to do with the neuroendocrine system than previously believed.
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We studied basal plasma FSH, LH, testosterone and oestradiol levels and post-OHRH plasma FSH and LH levels in ten patients both before and after a wedge resection of the ovaries for Stein-Leventhal syndrone. We compared the results with those obtained in 15 healthy patients between the third and seventh day of a normal menstrual cycle. Before operation, patients with the Stein-Leventhal syndrome had raised basal and post-LHRH LH levels and raised plasma testosterone levels. All these abnormalities disappeared after wedge resection of the ovaries. Both before and after operation patients with the Stein-Leventhal syndrome had low plasma oestradiol levels. These results are used to formulate a hypothesis about the aetiology of the Stein-Leventhal syndrome.
Twelve patients with Meyer-Rokitansky-Küster-Hauser syndrome were examined by means of pneumogynecography. The results obtained disclose the great diagnostic value of the method in this disorder.
The olfactory, auditory, and gustatory functions of 20 women with gonadal dysgenesis were studied. Various abnormalities of these functions were found, and they occurred principally in patients with mosaicism of the sex chromosomes. This is further evidence of the increased likelihood of various somatic abnormalities among women with gonadal dysgenesis, and particularly among those who carry more than one line of sex chromosomes.
Sex chromatin frequency was investigated in nuclei from epithelial cells of the oral mucosa in 20 healthy, mature newborn females in the first 10 days of the neonatal period and compared with the hormonal state of the infant. From the analysis of the results obtained it was evident that sex chromatin incidence of the newborn female fluctuated in the neonatal period in values similar to those of healthy, nonpregnant woman. However, a specific correlation was disclosed between the alterations of the sex chromatin frequency and the hormonal crisis of the newborn infant.
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Explore the source record for details and available documents.
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