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Biomedical subjects

S I Ivanov

Publications and source records attributed to S I Ivanov.

At least 19 recordsLinked to original sources

[General approach to evaluation, comparison and norm-setting of health risks associated with various environmental factors].

The authors analyze modern approaches to health risk evaluation and establishing safety standards concerning ionizing radiation, chemicals, and other health hazard sources. Some recommendations on general approaches are given. A special individual risk index is offered to make decisions concerning human safety: establishing safety standards and other levels of protection, comparing different health hazard sources, etc. General approach to establishing public and occupational safety standards in terms of this index has been developed.

Environmental Exposure↗

[Range of combined treatment of locally advanced skin cancer].

Due to combined use of surgery, chemo- and radiotherapy, 58.8% of patients with locally advanced squamous cell carcinoma survived for 5 years. More organ-saving operations could be performed as a result of administering cisplatin, bleomycin and 5-fluorouracil chemotherapy in conjunction with radiation and subsequent surgery. Greater extent of tumor excision and microsurgery involved lower incidence of relapse. Yet, the preliminary results of our combined treatment pointed to relatively high frequency of objective response matched by lower incidence of relapse which calls for further investigation.

Age Distribution↗

Solid cancer incidence among the Chernobyl emergency workers residing in Russia: estimation of radiation risks.

An analysis is presented of solid cancer incidence during 11 years of follow-up (1991-2001) of Chernobyl emergency workers residing in Russia. The analysis is based on data from the cohort of male emergency workers from 6 regions in Russia including 55718 persons with documented external radiation doses in the range of 0.001-0.3 Gy who worked within the 30 -km zone in 1986-1987. The mean age at exposure for these persons was 34.8 years and the mean external radiation dose 0.13 Gy. In the cohort 1370 cases of solid cancer were diagnosed and 3 follow-up periods were considered: 1991-1995, 1996-2001 and 1991-2001. The second follow-up period was chosen to allow for a minimum latency period of 10 years being characteristic of solid cancers. For risk assessment two control groups have been introduced, the first 'external' one representing incidence rates for corresponding ages in Russia in general, the second 'internal' one consisting of emergency workers. The risk estimates were based on spontaneous incidence rates of solid cancer. The estimated standardized incidence ratio (SIR) is in good agreement (95% CI) with that of the control. The values of excess relative risk per unit dose (ERR/Gy) for solid malignant neoplasms have been estimated to be 0.33 (95% CI: -0.39, 1.22) (internal control) for the follow-up period 1991-2001 and 0.19 (95% CI: -0.66, 1.27) for 1996-2001.

Chernobyl Nuclear Accident↗

[Dynamics of morbidity among liquidators of Chernobyl nuclear power station accident].

The article represents data on distribution of liquidators in Russian State Medical Dosimetry Register according to account categories, residing territories (regions of Russia), age, sex, dose groups, coverage by medical examinations and health groups. During 1991-1996 the liquidators demonstrated higher occurrence of endocrine, neurologic and sensory, circulatory, digestive and malignant diseases.

Adult↗

[Thermoradiotherapy in locally extensive soft tissue sarcoma].

The report discusses 138 cases of soft-tissue sarcoma: 92 patients initially received thermoradiotherapy, 46-radiotherapy. Local electromagnetic hyperthermia was found to potentiate the antitumor effect of ionizing radiation and to be followed by a significant increase in the frequency of complete and considerable regression of tumor, as compared with exposure to total doses of 30-32 Gy (66-70 Units). As a result, 5-year survival rate in cases of post-thermoradiotherapy conservative surgery rose to 54 +/- 5.2%, as compared with 26 +/- 6.8% after conservative surgery + radiotherapy. The percentage of patients who survived more than 5 years after conservative surgery + thermoradiotherapy or radiotherapy was 37 +/- 7 and 23 +/- 7.8, respectively.

Combined Modality Therapy↗