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S I Moiseev

Publications and source records attributed to S I Moiseev.

25 records · Page 2Linked to original sources
PubMed1986

[Characteristics of the changes in microcirculatory hemostasis in patients with exercise-induced stenocardia].

In patients with angina of effort all links in the system of microcirculatory hemostasis are activated and closely interconnected. Changes in one and the same index could be compensatory and pathological and it should be taken into account in attempts to interfere in the system of hemostasis. Lipid metabolic derangement in patients with angina of effort should be regarded as one of the most unfavorable factors in a course of disease. The prevention of angina attacks in such patients means the prevention of atherosclerosis progression.

Adult↗
PubMedDate not supplied

[Clinical experience using the cryoprotector "hecmolit" in performing autologous bone marrow transplantation].

The authors summarize clinical evidence obtained on the efficacy of a new Russian cryoprotector hecmolit in the conduction of autotransplantation of 8 patients with acute leukemia. The markers of the preserved hemopoietic potential of the unfrozen bone marrow were the amount of myelokaryocytes, their viability in the test with vital stain, CFU-GM level. Infusions of the marrow suspension incorporating hecmolit (120-180 ml) produced minimaL side effects. After thawing myelokaryocytes remained in the amount 81.7 +/- 8.2% or 1.6 +/- 0.4 x 10(8) cell / kg, on the average. Estimation of the aggregates in terms of the weight revealed that hemopoietic potential was sufficient for the transplant survival (2.9 +/- 0.7 x 10(3) CFU-GM/kg) though only 50 +/- 10% of CFU-GM remained safe. Hecmolit tolerance was satisfactory. The preparation is thought convenient for bone marrow transplantation practice.

Adolescent↗
PubMedDate not supplied

[Current principles of treatment of acute nonlymphoblastic leukemia].

Present-day chemotherapy warrants complete remissions in 45-70% of patients with acute nonlymphoblastic leukemia. However, therapeutic policy at the stages of remission induction and residual disease remains disputable. The authors studied the role of 3 chemotherapy programs (7 + 3, 7 + 3 + vincristine, C-ROPM) in achievement of remission of acute leukemia and effects of long-term standard regimens of remission maintenance and bone marrow transplantation on long-term relapse-free survival of patients. The addition of vincristine to the program 7 + 3 failed to make remission more frequent and recurrence-free survival longer. C-ROMP program warranted remission in 70% of patients, this proportion being significantly higher than on programs 7 + 3 and 7 + 3 + vincristine. More intensive chemotherapy during remission induction resulted in a rise of 4-year recurrence-free survival from 12 to 44%. Bone marrow transplantation used for treatment intensification in remission increased 4-year recurrence-free survival compared to standard chemotherapy from 44 to 80%.

Adolescent↗