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Biomedical subjects

S I Riabov

Publications and source records attributed to S I Riabov.

At least 19 recordsLinked to original sources
PubMed1996

[The problems in optimizing the delivery of general therapeutic care at the regional level during the transition to compulsory medical insurance].

The authors hold that perfection of local therapeutic service in present-day situation when insurance principles are introduced in medical care may be achieved through design of medico-economic standards of guaranteed minimum of medical aid for each citizen of Russian Federation. This approach allows accurate estimation of required personnel and equipment. The standards should not replace the principle of individual approach to each case.

Delivery of Health Care↗
PubMed1996

[Assessment of the clinical course of chronic glomerulonephritis].

Clinical course of chronic glomerulonephritis (CG) with recognition of 4 types by frequency of exacerbations was investigated in 592 patients with morphologically verified diagnosis observed for a long time. The disease ran a stable course. Contrary to patients with mesangioproliferative CG who had rare or moderate-frequency exacerbations, patients with membranoproliferative disease had exacerbations annually. This suggests correlation between the form of anatomical changes and the process activity. Irrespective of CG morphological form, the survival of CG patients is closely related to the disease course. Taken into account, this fact may serve the tool of prognosis, choice of treatment intensity and duration of follow-up.

Actuarial Analysis↗
PubMed1996

[New approaches to therapy in glomerulonephritis patients].

Before starting treatment of chronic glomerulonephritis it is desirable to determine the patient's drug sensitivity in vitro because in the absence of such sensitivity chemotherapy should be preceded by immunomodulation with tactivin or thymalin and 3-5 sessions of plasmapheresis to stimulate drug sensitivity. Further measures include prednisolone or cyclophosphamide intravenously for 3-5 days in a dose 300-500 followed by oral administration. Active treatment lasts for 4-8 weeks. After that the patients receive maintenance for 1-2 years.

Antineoplastic Agents↗
PubMed1996

[Aortic valve prosthesis and the plication of a dissecting aneurysm of the ascending aorta in a patient with infectious endocarditis against a background of chronic kidney failure and its management by regular hemodialysis].

Some literature data are presented on the problem of cardiac surgery in patients with chronic renal insufficiency under regular hemodialysis and on the specificity of performing operations on such patients under conditions of artificial circulation. The authors describe their first experience of a one-step prosthezing of the aortal valve and plication of the dissecting aneurysm of the ascending part of the aorta in the patient receiving the regular hemodialysis during 5 years as well as the positive results of this original operation in dynamics of the first year of observations.

Acute Disease↗
PubMed1996

[Structural-metabolic features of uremic gastroenteropathy].

Concentrations of uremic toxins in the blood and jejunal juice of 72 patients with chronic renal failure (CRF) were studied as well as morphologic changes in biopsies from jejunal mucosa and submucosa, activity and location of acid and alkaline phosphatase as markers of intracellular and transmembrane transport. It was found that maximal excretion of uremic toxins in the jejunum occurs in CRF stage IIA and IIB. In terminal CRF excretion of uremic toxins delays from their concentration in the blood. This process is related with changes in enzymic processes. Histologically, all the examinees exhibited signs of chronic enteritis.

Chronic Disease↗
PubMed1996

[The effect of Recormon therapy on the quality of life of patients on hemodialysis treatment].

Recormon was given to 34 patients on hemodialysis. The drug's effects on quality of life were judged by the results of clinical, laboratory, experimental and psychological dynamic investigations. The highest effect occurred on the therapy month 6-12. Recormon contributed to relief of asthenic and depressive syndromes, to an increase of activity and improvement of well-being, quality of life by Karnofsky scale within the first year of treatment. The dynamics of life quality changes depended on initial psycho-physical condition of the patients, the age, blood pressure, hematocrit. Recormon treatment is associated with the risk of euphoria.

Adult↗
PubMed1996

[Variants in the transient deterioration of kidney function in chronic glomerulonephritis].

A transient inhibition of glomerular filtration and/or elevation of blood creatinine were detected in 126 of 296 patients with chronic glomerulonephritis. Some of the patients had 2-4 episodes which occurred more frequently in exacerbations (56.3% of cases), less frequently in cytostatic treatment or in sanatorium. The predominance of nephrotic syndrome and frequent recurrences or hypertension, long-term course in different causes of the disease suggests several pathogenetic variants of nephrotic syndrome. Transient deterioration of renal function does not affect survival, but its emergence in the course of cytostatic treatment or sanatorium treatment worsens the prognosis being related with sclerosis of the renal tissue.

Adult↗
PubMed1995

[Lipid peroxidation and the system of antioxidant protection in patients with chronic glomerulonephritis and normal kidney azoturic function].

As indicated by blood tests, chronic glomerulonephritis (CGN) patients with intact renal function have impaired lipid peroxidation and antioxidant defense. In nephrotic syndrome these plasm changes are more pronounced, but red cells remain relatively intact. Persistent nephrotic syndrome produces a trend to shifts in red blood picture. In CGN patients free of nephrotic syndrome red cells exhibited lipid peroxidation and weak antioxidant defense. The above facts support the validity of antioxidants use in combined treatment of CGN.

Adult↗
PubMed1994

[Results of treatment of patients with chronic glomerulonephritis at different health resorts].

The results of sanatorium treatment were compared for different health resorts (in the Middle Asia, Yalta, Sestroretsk) where 374 patients underwent 455 courses for chronic glomerulonephritis. The results of the treatment were similar except for the Middle Asia and Yalta sanatoria where the condition of the patients aggravated. This suggests a conclusion of an unfavorable effect of hot climate on the course of chronic glomerulonephritis.

Chronic Disease↗
PubMed1994

[New findings in the pathogenesis of chronic glomerulonephritis].

30 untreated patients with membranoproliferative glomerulonephritis (MPGN) with isolated urinary syndrome were examined for cellular and humoral immunity. There was a significant (p < 0.05) reduction of the number of T-helpers/inductors (T4/4B4) and early undifferentiated lymphoid precursors with the marker enzyme. T-lymphocytes with markers T1, T3, T11, T12 as well as T-suppressors/cytotoxic cells (T8/2H4) occurred in normal quantities. IL-1 and IL-2 production was inhibited. Mature T-lymphocytes with markers T11, suppressors T8, early precursors of T-cells (T6) were higher in number in development of dystrophic changes in tubular epithelium. It is suggested that T-cell factor may be involved in nephron impairment observed in MPGN patients. Humoral immunity disorders are of the secondary nature.

Animals↗
PubMed1994

[The progression rates of different morphological forms of chronic glomerulonephritis in the pre-azotemia period (is the morphological form of chronic glomerulonephritis the factor that determines the prognosis?)].

The multivariate analysis of overall clinicomorphological symptoms in 121 patients with chronic glomerulonephritis (CGN) allowed formulation of independent prognostic factors indicative of the time to chronic renal failure. Similar for diverse morphological CGN forms prognostic characters are those of CGN aggravation frequency, arterial hypertension, serum creatinine concentration, the pattern of tubulointerstitial changes at the time of renal biopsy. The speed of CGN morphological variants is approximately the same in similar expression of prognostically significant characters.

Adult↗
PubMed1994

[Changes in the filtration function of the kidneys during the treatment of chronic glomerulonephritis].

The implications of the treatment variant and chronic glomerulonephritis (CGN) characteristics in the changes of renal function were evaluated by 220 treatment courses for CGN aggravation. A number of statistical methods were employed. In CGN patients free of renal insufficiency glomerular filtration was either unaffected or recovered after transitory decline. In chronic failure further creatinine clearance diminution was observed, serum creatinine levels went up. Corticosteroid treatment was much safer for the kidneys than cytostatics. With increasing duration of CGN, functional affection of the kidney becomes more frequent irrespective of the treatment kind. The same is true for the number of exacerbation and hypertension which are also involved in renal functional decline.

Adolescent↗
PubMed1993

[A trial of the clinical use of intestinal dialysis in chronic kidney failure].

The authors analyze pilot experience with clinical introduction of intestinal dialysis in 7 uremic patients. Repeated sessions of the dialysis relieved some symptoms of uremic intoxication. The method may be of value in contraindications to chronic hemodialysis for chronic renal failure. The technique is easily performed and well tolerated by the patients. The investigations should be continued.

Adult↗
PubMed1992

[Evoked potentials and electric resistance of the cerebral cortex under the effects of strychnine and atropine].

The effect of strychnine and atropine on the amplitude of the evoked potentials (EP) of the cerebral cortex was studied. It was shown, that both drugs increased amplitude of the EP. When we used strychnine, increased amplitude of the EP determined modification of the electrical resistance and current sources of the electrical field of the EP. Atropine did not change electrical resistance and in this case only electrical current sources determined modification of the EP.

Animals↗