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Biomedical subjects

S I Sergeev

Publications and source records attributed to S I Sergeev.

18 recordsLinked to original sources
PubMed1978

[Copper content and the ceruloplasmin activity in the blood in melanoma of the skin].

In comparative studies on the copper content and ceruloplasmin activity in blood of 212 patients with malignant melanoma, cancer and benign skin neoplasms, hypercupremia and an increased activity of the enzyme was revealed in 80% of patients with melanoma. Serum copper uptake in patients with non-pigmented melanoma was manifest to a greater extent. Some redistribution mechanisms are likely to underlie hypercupremia, that is especially indicated by the migration of copper from blood erythrocytes. Hypercupremia in patients with melanoma may be of a certain clinical interest as an accessory criterion for the differential diagnosis between malignant melanomas and benign skin neoplasms.

Adolescent↗
PubMed1977

[Hyperbaric oxygenation in the preoperative radiotherapy of soft tissue sarcomas].

Based on the study of clinical and morphological criteria for estimation of the efficacy of distance gammatherapy under hyperbaric oxygenation in the combined treatment of patients with soft tissue sarcomas, it was concluded that hyperbaric oxygenation employed in radiotherapy contributed to the increased rate of neoplasms damage. The latter resulted in a decreased percentage of the recurrence. The attenuation of local radiation and less number of postoperative complications indicate that healthy tissues surrounding the tumor are preserved. No rise in the percentage of distant metastases was noted in irradiation under hyperbaric oxygenation.

Adult↗
PubMed1976

[Humoral immunity in human sarcomas].

Studies on humoral immunity were performed in sarcoma patients before, during and after the treatment. Cytotoxic test was carried on with target cells of human mesenchymoma stable line. The activity of serum and its immunoglobulin fractions in 15 patients with soft tissue sarcoma and in 10 patients with congenital sarcoma was studied. It was found that 19S fraction of patient's blood serum contains cytotoxic antibodies. 7S fraction was permanently inactive. The whole serum was cytoloxic before the treatment in 8 of 12 patients with soft tissue sarcoma. Among 20 healthy donors only 3 were active. There was revealed a possibility of strong specific binding of 19S immunoglobulins (and more rarely of 7S immunoglobulins) with target-cells surface. It evidences the capacity of immunoglobulins to render not only cytotoxic action but also presumably, a blocking effect. Irradiation treatment in doses of 1800-9000 rad fail to diminish the cytotoxic activity of the whole serum and its 19S fraction.

Antibodies, Neoplasm↗
PubMed1976

[Metastatic tumors of the retroperitoneal space].

In 22 patients retroperitoneal nonorganic tumors, considered to be primary, proved to be metastatic. Prior to surgery the character of neoplasms was recognized only in 4 patients. Due to unwarranted efforts of "radical" removal of tumors 2 of 4 patients died. In 3 cases neoplasms were urgently removed due to internal hemorrhage and obstruction. In 7 cases a palliative effect of radiotherapy. 5-fluoruracil thiophosphamide employed prior to detection of the primary focus, was obtained. The latter was found following 3-12 months in the stomach (1), small intestine (1) and rectum (4), kidneys (4) and genitalia (9) in further follow-up of patients.

Adult↗
PubMed1976

[Activity of lymphocytes from patients with malignant melanoma in a culture with phytohemagglutinin].

In the present work, the authors have employed a test for blasttransformation and mitotic activity of lymphocytes in the culture with phytohemagglutinin (PHA-Difeo) to estimate the state of cell immunity in patients having malignant melanoma (95). A correlation was made between these tests and the number of lymphoid cells in patients blood prior to and 10--14 days after surgery, radio- and combined therapy. The most informative index of the cell immunity state in patients with malignant melanoma before application of special therapeutic measures was the absolute number of lymphocytes in blood, while following the treatment- the kinetics of the complex of tests under study.

Adult↗
PubMed1975

[Rehabilitative and supportive therapy for oncologic patients].

The results of treatment in 674 oncological patients in a special department of accessory therapy have been studied. The patients admitted were previously subjected to various kinds of radical surgery. The analysis has evidenced that due to a careful dynamic exploration of patients and pathogenetic therapy with a protective regimen and labor therapy, the results of surgical treatment in patients with cancer of the stomach, lung and mammary gland were found to be considerably improved. This is especially evident from observations over patients with lung cancer. Among 168 patients followed up since 1965 up to date 126 patients (75%) show no signs of tumor recurrence. Thus, there can be no doubts as to the rationality of further elaboration of rehabilitation measures in oncological patients.

Adult↗