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Biomedical subjects

S I Tkachev

Publications and source records attributed to S I Tkachev.

At least 19 recordsLinked to original sources
PubMed2005

[Thermoradiotherapy as a component of desmoid tumor management: 10-year experience].

Data on radio- and thermoradiotherapy of 83 patients with extra-abdominal desmoid tumors are discussed. In a group of 57 patients followed up for 10 years or less, the relapse-free survival rates, in thermoradiotherapy-treated cases, were significantly higher (74.4% and 28.6%) than in those receiving radiotherapy (9.3% and 57.1%). Monitoring tumor temperature during local hyperthermia is a factor of relapse-free survival of vital importance.

Disease-Free Survival↗
PubMed2005

[Thermoradiochemotherapy of inoperable soft-tissue sarcoma].

Three groups of patients with inoperable soft-tissue sarcoma received preoperative radiotherapy (57), thermoradiotherapy (102) and thermoradiochemotherapy (16) (n=175). Five year recurrence-free survival in group 1 was 37+/-7%, group 2 48+/-6%, and group 3 - 56+/-1,7%. Patients survived 5 years and more in group 3 (60+/-2%), group 2 - 50+/-7%, and group I 44+/-8% (p>0.05). Local hyperthermia used in conjunction with radio- and chemoradiotherapy was followed by a significant rise in the rate of complete and partial tumor regression.

Adult↗
PubMed2005

[Radiotherapy as a component of treatment for Ewing's sarcoma].

The main stages of development of such conservative modalities as radio- and chemoradiotherapy for localized Ewing's sarcoma are discussed. Factors affecting five-year overall and recurrence-free survival of patients treated with chemoradiotherapy are presented.

Adult↗
PubMed2005

[Range of combined treatment of locally advanced skin cancer].

Due to combined use of surgery, chemo- and radiotherapy, 58.8% of patients with locally advanced squamous cell carcinoma survived for 5 years. More organ-saving operations could be performed as a result of administering cisplatin, bleomycin and 5-fluorouracil chemotherapy in conjunction with radiation and subsequent surgery. Greater extent of tumor excision and microsurgery involved lower incidence of relapse. Yet, the preliminary results of our combined treatment pointed to relatively high frequency of objective response matched by lower incidence of relapse which calls for further investigation.

Age Distribution↗
PubMed2001

[Problems of radiation therapy of patients with malignant tumors and modern ways of resolving them].

At the present stage of radiation oncology, treatment successes are mainly determined by improvement of multimodality therapy that utilizes benefits of each modality in individual patients. Radiotherapy is mostly empiric, as demonstrated by dose fractionation. Its significance in many situations is underestimated, which leads to unreasonably excessive irradiation or, vice versa, to its unreasonable refusal. So clinical searches for new knowledge of the actual role of radiotherapy in specific clinical situations are therefore continued. The advent of new-generation radiation therapy apparatuses opens up fresh opportunities for development of rational radiation methods by mathematically optimizing dosage fields of irradiation and creating its conformable conditions. The necessary conditions for further radiotherapy successes are continuation of research developments in rational simulation of spatial dosage distribution, in the use of radio sensibilizers and radio protectors, and in contact methods of radiotherapy and intraoperative irradiation.

Humans↗
PubMed1999

[Standard and hyperfractionated irradiation for locally advanced tumors (T3NOMO) of the larynx].

Two modalities of radiotherapy of locally advanced tumors (T3N0M0) of the larynx were compared in the treatment of 89 patients. Forty-six patients of group I received 2 Gy daily, 5 times a week (COD 65-70 Gy), while 43 patients of group 11--1.1 Gy of multifractionated radiation twice a day, at 4-hr interval (COD 70-75 Gy). Five-year survival in group 1 was 67.1--11%, recurrence-free rate--54 +/- 7.3%, while in group 11--76 +/- 6.5 and 67 +/- 7.1%, respectively, (p < 0.4).

Adult↗
PubMed1999

[Preoperative thermoradiotherapy in the combined treatment of rectal tumors is the inferior ampullar segmentŏ].

Data on the examination of 260 radically-treated patients with rectal tumors in the inferior ampullar segment are presented. 107 patients received surgery alone, another 75--preoperative radiotherapy, while still another 78--preoperative thermoradiotherapy. Combined treatment of stage III tumors significantly reduced recurrence incidence and was followed by significant increase in recurrence-free survival rates. In cases of tumor disseminated to the regional lymph nodes, recurrence-free survival was observed after preoperative thermoradiation only.

Adult↗
PubMed1998

[Problems of dose fractionation in radiotherapy of patients with locally advanced esophageal cancer].

Patients with local inoperable tumors of the esophagus received a radiation course consisting of three modalities--conventional, continuous accelerated and split fractionation using large single fractions. Significant overall beneficial effect--complete or partial remission--was registered more often in those treated with the two non-traditional modalities. Their application was followed by a 20% rise in palliative effect.

Dose Fractionation, Radiation↗
PubMed1998

[Adjuvant radiotherapy in the combined treatment of rectal cancer].

Radiotherapy was given postoperatively to 37 out of 81 patients with metastases into the regional lymph nodes (stage C after Dukes) to prevent relapse. All the patients had undergone radical surgery. No significant decrease in relapse incidence could be achieved unless an absorbed dose of 40 Gy was received postoperatively. However, combined treatment failed to produce a significant rise in five-year survival due to deaths from distant metastases.

Combined Modality Therapy↗
PubMed1996

[Use of thermal radiochemotherapy in patients with anal epidermoid cancer].

The authors have developed a new original procedure for combined and multimodal treatment of patients with anal dermoid cancer, which includes radiation therapy, polychemotherapy (platidiam and bleomycin) by using topical superhigh-frequency hyperthermia and antioxidants. The treatment regimen proposed has turned out to be highly effective. It allows sphincter-preserving therapy to be performed without rectal extirpation in most primary patients with anal dermoid cancer.

Antibiotics, Antineoplastic↗
PubMed1996

[Thermoradiotherapy in locally extensive soft tissue sarcoma].

The report discusses 138 cases of soft-tissue sarcoma: 92 patients initially received thermoradiotherapy, 46-radiotherapy. Local electromagnetic hyperthermia was found to potentiate the antitumor effect of ionizing radiation and to be followed by a significant increase in the frequency of complete and considerable regression of tumor, as compared with exposure to total doses of 30-32 Gy (66-70 Units). As a result, 5-year survival rate in cases of post-thermoradiotherapy conservative surgery rose to 54 +/- 5.2%, as compared with 26 +/- 6.8% after conservative surgery + radiotherapy. The percentage of patients who survived more than 5 years after conservative surgery + thermoradiotherapy or radiotherapy was 37 +/- 7 and 23 +/- 7.8, respectively.

Combined Modality Therapy↗
PubMed1992

[An assessment of the efficacy of preoperative radio- and thermoradiotherapy in treating rectal cancer].

Immediate results of combined and surgical treatment of 415 patients with stage III rectal cancer were analysed. Combined treatment including intensive preoperative irradiation and preoperative thermoradiotherapy was not associated with higher postoperative lethality as compared to surgery alone, the indexes being 1.9 +/- 0.9%, 3.8 +/- 2.6% and 2.7 +/- 1.3%. Pyoinflammatory complications developed in 40.7 +/- 3.3% and 45.6 +/- 6.8% of cases in the two combined treatment groups, respectively, and in 33.2 +/- 3.8% in the control group. In patients subjected to preoperative irradiation in combination with microwave hyperthermia, no increase in the occurrence of pyoinflammatory complications was observed, but surgical wounds took longer to heal. The rate of complications following sphincter-sparing procedures, whether used alone or in combination treatment, was similar. It is concluded that the use of combined modality treatment should not bar sphincter-sparing surgery.

Adenocarcinoma↗
PubMed1991

[The thermoradiotherapy of malignant salivary gland tumors].

The paper is devoted to the discussion of problems of the effectiveness of thermoradio- and radiotherapy of patients with locally advanced malignant tumors of the salivary glands. The 1st group of 14 patients received gamma-beam therapy, and the 2nd group of 32 patients was given radiotherapy combined with local microwave hyperthermia. After delivering a dose of 40 Gy a decrease of a tumor size by greater than 50% was noted in 50% of the patients of the 1st group and in 76% of the patients of the 2nd group. Thermoradiotherapy prove to be most effective in patients with adenoid cystic carcinoma, tumor regression over 75% was noted in half of them. Complications in thermoradiotherapy were unnoticed.

Combined Modality Therapy↗