[Pathophysiological basis of using animal experiments].
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Biomedical subjects
Publications and source records attributed to S Ia Zhuravlev.
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The functional activity of the transplanted (additional) liver and its efficiency in the treatment of critical hepatic insufficiency was studied in experiments on dogs. Without an immunosuppression being used the additionally transplanted liver manifests its functional activity in the recipient's organism within 4 days and is able to support the animal's life for 3-4 days.
The ways of settling some surgical aspects of a temporary heterotopic transplantation of the liver are analysed in the article. According to the obtained data the placement of the graft into the iliac zone of the abdominal cavity is the most convenient for a temporary heterotopic transplantation of an additional liver. An adequate vascularization of the additional organ can be effected via hepatic artery, which simplifies considerably the removal and replacement of this organ. For a free placement of the graft the weight of the donor should be 2 or 3 times less than that of the recipient.
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