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S Imagama

Publications and source records attributed to S Imagama.

4 recordsLinked to original sources
PubMed2004

Intestinal thrombotic microangiopathy after allogeneic bone marrow transplantation: a clinical imitator of acute enteric graft-versus-host disease.

Thrombotic microangiopathy after bone marrow transplantation (post-BMT TMA) is a serious transplant-related complication. We identified 16 patients with TMA after allogeneic BMT who showed histopathological evidence of intestinal TMA in their gut specimens (six autopsies, 10 biopsies). In all, 14 patients had grade II-IV acute graft-versus-host disease (GVHD). The first seven patients were retrospectively diagnosed with TMA. Since six of them were diagnosed with progressive GVHD at that time because there was no awareness of the existence of intestinal TMA, they received more intensive treatment for GVHD, but all died between days +49 and +253. In contrast, the remaining nine patients were recently diagnosed with intestinal TMA on the basis of colonoscopic biopsies. For eight of these patients, the immunosuppressants were reduced, and the patients' intestinal symptoms improved gradually. Six of the nine patients were still alive 12 months after the diagnosis of TMA. Our findings suggest that the gut may be a site involved in post-BMT TMA, presenting as ischemic enterocolitis. Differentiating intestinal TMA from acute GVHD is important in patients suffering from severe and refractory diarrhea after BMT.

Acute Disease↗
PubMed1990

Three-dimensional analysis of averaged electroretinograms for the evaluation of rhegmatogenous retinal detachment and related pathological conditions.

Retinal functional imaging in patients with rhegmatogenous retinal detachment and related pathological conditions was undertaken in 62 eyes of 44 cases by means of three-dimensional analysis (X-Y plane and time) of electroretinogram (ERG) topography. The analysis revealed that the area of maximal amplitude in both dominantly photopic and scotopic conditions deviated to the skin area closest to the location of the retinal detachment (hereafter referred to as paradoxical localization). In temporal retinal detachment, for example, the location of the maximal amplitude of the a- and b-waves deviated toward the temporal side on surface topography. Flicker ERG with a stimulus frequency of 30 Hz was especially successful for disclosing the existence and the location of posterior involvement of retinal detachment within the area surrounding the temporal vascular arcades. The mechanisms of paradoxical localization were considered to be changes in the axis of the equivalent dipole in detachment eyes. These abnormalities disappeared after the retina was reattached. Although the buckling procedure and argon laser retinopexy had little effect on the topographical distribution of the a- and b-waves, it was markedly distorted by cryoretinopexy. No remarkable changes in the topographical distribution of the waves were detected in pathological conditions predisposing to rhegmatogenous retinal detachment. This new method for functional imaging of the retina promises to be valuable for objective clinical evaluation of retinal detachment.

Adult↗
PubMed1989

[Three dimensional analysis (XY plane and time) of averaged electroretinograms for the evaluation of rhegmatogenous retinal detachment and related pathological conditions].

Retinal functional imaging in patients with rhegmatogenous retinal detachment and related pathological conditions was investigated by three dimensional analysis of ERG topography. The three dimensional analysis revealed that the area of maximal amplitude deviated to the skin area closest to the location of the retinal detachment (paradoxical localization). In temporal retinal detachment, for example, the maximal amplitude of the a- and b-waves deviated toward the temporal side on the surface topography. The depth of the retinal detachment was clearly indicated by differential ERG topography. Flicker ERG with a stimulus frequency of 30Hz was especially successful in showing the existence and location of macular detachment within the area surrounding the temporal vascular arcades. ERG topography also indicated the meridional extent of retinal detachment. When there was detachment in two quadrants (e.g., two inferior quadrants), deviation in the surface topography of a- and b-waves appeared in the same quadrants. When detachment expanded into three quadrants, deviation of the amplitude of a- and b-waves closely resembled the extent of the detachment. In addition, however, there was inverse a- and b-wave surface topography on the opposite skin area. When there were two quadrants of retinal detachment, there were two quadrants of inverse a-and b-waves. When there were three quadrants of retinal detachment, there was only one quadrant of inverse a- and b-waves. No inverse a- and b-waves were detected when there was only one quadrant of retinal detachment. In such cases, however, deviation in the surface topography covered three quadrants. These abnormalities were detected in 90.6% of all cases with the retinal detachment disappeared after the retina was reattached. While the buckling procedure and argon laser retinopexy had little effect on the topographical distribution, it was markedly distorted by cryoretinopexy. No remarkable changes in the topographical distribution of a- and b-waves were detected in pathological conditions related to rhegmatogenous retinal detachment. This new method for functional imaging of the retina should be valuable for objective clinical evaluation of retinal detachment.

Adult↗