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S Irvin

Publications and source records attributed to S Irvin.

6 recordsLinked to original sources
PubMed2000

The experiences of the registered nurse caring for the person dying of cancer in a nursing home.

This paper reports on research that set out to identify and describe the experiences of the registered nurse caring for the resident dying of cancer in a nursing home. The research method used was a qualitative single case study involving five registered nurses in one nursing home. Thematic analysis of data from unstructured interviews and reflective journals was used to explicate the nurses' experiences. Four major themes were extracted from the data. These themes were the exclusivity of the relationships, difficulties in the management of pain, the expectations of the registered nurse and the impact of caring. The nurses' experiences were loving, fascinating, compelling and rich. The overarching experience of the nurses came from the relationship they formed with the residents. A crucial finding in this study was that these registered nurses valued the elderly resident and developed meaningful relationships with them. All aspects of the relationships were unique and profound. However, the emotional involvement with the resident, multiple death losses, confrontation of personal losses, limited workplace support such as counselling, potentially places these registered nurses at emotional risk from burnout and complicated bereavement. The implications of these findings for nursing practice, education and research are discussed.

Adaptation, Psychological↗
PubMed1997

A Bcl-2 antisense oligonucleotide increases alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) toxicity in cortical cultures.

Both alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated neurotoxicity and the induction of death-regulatory genes have been implicated in the pathophysiology of delayed ischemic neuronal injury. To assess the role of the antiapoptotic gene Bcl-2 in the modulation of AMPA toxicity, we exposed neuron-enriched cultures from rat cerebral cortex to AMPA, in the absence or presence of an antisense oligodeoxynucleotide (ODN) directed against Bcl-2. AMPA produced concentration-dependent toxicity detected by a decrease in fluorescence of the redox indicator Alamar blue and by an increase in lactic acid dehydrogenase release. This effect was accompanied by the induction of Bcl-2 protein expression, with maximal induction at 100 microM AMPA. A phosphorothioate antisense ODN against Bcl-2 reduced the AMPA-stimulated induction of Bcl-2 protein levels, detected by western blotting, by about 70%. In the presence of the antisense ODN, but not sense or scrambled ODNs, the toxicity of 100 microM AMPA was increased by about 60%. These findings suggest that induction of Bcl-2 expression by AMPA may have a protective role to limit AMPA receptor-mediated neuronal damage and that modifying Bcl-2 expression could have therapeutic potential in ischemia.

Animals↗
PubMed1996

Alexithymia, anger, and interpersonal behavior.

BACKGROUND: We explored the relationship between alexithymia and interpersonal behavior, particularly the expression of anger. METHODS: Ninety-eight college students completed the Toronto Alexithymia Scale. A median split was used to divide participants into a low-alexithymia and a high-alexithymia group. The experimenter intentionally engaged in a series of anger-provoking behaviors. RESULTS: Compared to individuals in the low-alexithymia group, individuals in the high-alexithymia group were more interpersonally avoidant and exhibited more nonverbal anger, yet there was a trend for them to describe their lab experience as more pleasant. Among individuals in the high-alexithymia group, the different measures of anger and interpersonal behavior were less strongly associated than they were among individuals in the low-alexithymia group. CONCLUSIONS: The results provide evidence of a complex association between alexithymia and anger, and of the lack of coherence in the communication of individuals with high levels of alexithymia.

Adolescent↗
PubMedDate not supplied

Methodologic issues in randomized trials of liaison psychiatry in primary care.

Most anxiety, depressive, and substance abuse disorders are treated exclusively in the primary care health system. However, recognition and treatment of these disorders in primary care is deficient. Psychopharmacologic and psychotherapeutic interventions have been developed and proven effective in randomized trials in specialty care. However, the results of successful trials of mental health interventions in specialty settings may not generalize to primary care settings because of epidemiologic differences in patients, differences in skills of providers, as well as differences in the very structure of care. The importance of the development of innovative randomized trials to improve recognition and treatment of mental illness in primary care is emphasized, as well as the methodologic problems inherent in carrying out these trials.

Humans↗