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Biomedical subjects

S Isaka

Publications and source records attributed to S Isaka.

108 records · Page 6Linked to original sources
PubMed1977

[Therapeutic effect of pipemidic acid trihydrate on urinary tract infections (author's transl)].

Twenty-seven cases of urinary tract infection were treated with daily dose of 1.5 g of pipemidic acid trihydrate. Duration of drug administration varied between 7 and 28 days. The patients were consisted of acute cystitis (10), underlying disease (5) and complicated infection after long period catheterization (12). Following results were obtained: 1. Organisms cultured before treatment were sensitive to pipemidic acid trihydrate. 2. First and second classes of patients were cured by the treatment, however, patients having indwelling catheter were not changed on the view of culture. 3. No serious side effect was observed including hepatic and renal function, and blood.

Adult↗
PubMedDate not supplied

Mutational state of von Hippel-Lindau and adenomatous polyposis coli genes in renal tumors.

Genetic alterations of the von Hippel-Lindau (VHL) tumor suppressor gene and the adenomatous polyposis coli (APC) gene in renal tumors were examined by PCR-SSCP analysis and direct sequencing. Tissues from 58 primary sporadic human renal cell tumors (49 clear-cell carcinomas, 6 non-clear-cell carcinomas and 3 oncocytomas) from Japanese patients were used in this study. Somatic VHL mutations were detected in 26 (53%) of the clear-cell carcinomas, although no mutations in this gene were observed in any non-clear-cell carcinomas or oncocytomas. The frequency of mutations did not correlate with histological grade, clinical stage or any of several other clinical factors examined. No differences in the frequency of VHL mutations or in the exons where mutations occurred within the gene were evident when we compared our results with those reported for American patients. However, frameshifts were more common in our Japanese panel of tumors than in American cases, where single-point mutations appear to be more frequent. No APC gene mutation was detected in any of our samples. These results indicate that VHL gene mutations are related to the carcinogenesis of the clear-cell type of primary renal cell carcinomas, whereas alteration of the APC gene is not involved in the pathogenesis of this cancer.

Adenomatous Polyposis Coli↗