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Biomedical subjects

S Isenberg

Publications and source records attributed to S Isenberg.

27 records · Page 2Linked to original sources

Studies on L-serine deaminase in Escherichia coli K-12.

l-Serine deaminase has been studied in toluene-treated cells of Escherichia coli K-12 and shown to be a discrete entity distinct from l-threonine deaminase. Its level in the cell varies as a function of nitrogen nutrition, carbon source, and amino acids (glycine and leucine). The metabolic role of the enzyme remains unclear but may be related to serine toxicity. The enzyme is unstable within the cell in the presence of its inducers, glycine and leucine, but not in their absence.

Amino Acids

Systemic effects of mydriatics in low weight infants.

Two-and-a-half percent phenylephrine eye drops were used in combination with 0.5% tropicamide for routine pupillary dilation in 10 low weight infants. Significant systolic blood pressure elevation was noted in eight of 10 infants. A matched control group dilated with cycloplegics alone did not show a significant rise in systolic blood pressure. The mean change in pupillary dilation in the study group was 3.9 mm compared with 3.1 mm in the control group. This difference is not statistically significant. We therefore recommend that cycloplegic agents alone be used for pupillary dilation in these high risk infants.

Blood Pressure

Marcus Gunn jaw winking and Duane's retraction syndrome.

A three-month-old female presented with the unusual findings of Marcus Gunn Jaw Winking Phenomenon and Duane's Retraction Syndrome in the same eye. In considering suggested etiologies for these two disorders, a misdirection of peripheral innervation would account for both these entities co-existing. In reviewing the ophthalmic literature, the association of these disorders was first described around the turn of the century but much less in recent years.

Blepharoptosis

Torsion and elevation under general anesthesia and during voluntary eyelid closure (Bell phenomenon).

The amount and interrelationship of ocular torsion and elevation was measured in 30 patients under general anesthesia; half received muscle relaxants (pancuronium bromide) during induction and half did not. Similar measurements were made in 20 patients during voluntary eyelid closure (Bell phenomenon). The mean amount of excycloduction was between 2.0 degrees and 2.5 degrees when the patients were under general anesthesia, whether or not muscle relaxants were used, and during voluntary eyelid closure. No statistically significant difference in the amount of torsion was found among the three groups. Elevation was significantly greater during voluntary eyelid closure (mean 5.3 mm) than during general anesthesia (p less than 0.01). No statistically significant difference in ocular elevation was found in patients under general anesthesia whether they were given a muscle relaxant (mean 1.5 mm) or not (mean 1.2 mm).

Adolescent