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Biomedical subjects

S J Baum

Publications and source records attributed to S J Baum.

5 recordsLinked to original sources
PubMed1978

Stimulatory effects of products from inflammatory exudates upon stem cell production.

The present study is based on the hypothesis that a humoral agent produced in inflammatory exudates is transported to the bone marrow where it stimulates CFU-S to differentiate into leukocytic precursors. Inflammatory exudates were produced by the subcutaneous implantation of a sterile acrylic cup filled with bacteria-free Hanks' balanced salt solution (HBSS) into B6D2F1 mice. The cups were removed 24 h later and the cells were separated from the supernatant. Cells collected from individual mice were pooled, as was the supernatant. Thereafter, normal mice received via tail vein either exudate cells, supernatant, plasma from cup-implanted or from normal mice, bone marrow cells or splenic cells from normal animals or HBSS. Another 24 h later bone marrow was removed from all mice and injected into previously lethally irradiated mice or suspended in vitro in agar-supported media. Nine days later the mice were euthanatized, the spleens removed, and colonies (CFU-S) counted. At the same time, colonies (CFU-C) were enumerated from the agar plates. The results clearly indicate that the bone marrow obtained from mice stimulated with either exudate cells or with super-natant or plasma obtained from cup-implanted mice contained a significantly greater number of CFU-S and CFU-C than did any one of the four control groups. These findings appear to substantiate the hypothesis.

Animals↗
PubMed1977

Nasal projection.

The challenge of enduring tip projection is met with the use of a septal cartilage graft between the medial crura. With suturing, a "sandwich" is created composed of the two medial crura and the graft between them. The sandwich can be trimmed as necessary, in accordance with the surgeon's taste requirements for good tip profile and projection. The graft allows much more projection than from the medial crura alone. We describe the Goldman technique of rim incisions, delivery of the lower lateral cartilages, bisection of each, and then creation of the sandwich. The technique has been performed on more than 40 patients, in most of whom the results have remained successful more than six months postoperatively. The results indicate excellent fixation of the projected tip with maintenance of position, strength, and form. The indications for this tip technique are the classical ones for medial crura projection, such as hypoplastic tip cartilages, short columella revision rhinoplasty, and most importantly, the increase of real projection not attained by simple rotation.

Cartilage↗