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S J Cheng

Publications and source records attributed to S J Cheng.

50 records · Page 3Linked to original sources
PubMed1985

A mutagenic metabolite produced by Fusarium moniliforme isolated from Linxian county, China.

Fusarin C, a fungal metabolite, was recently isolated and identified from corn meal inoculated with Fusarium moniliforme which was one of the most common fungi associated with corn in Linxian county, a high-incidence area of esophageal cancer. In the presence of S-9 mix, fusarin C significantly increased the number of revertants in Salmonella typhimurium TA 100, and induced SCE, micronuclei, chromosome aberrations and 6-TG resistant mutants in V79 cells. The toxic action of fusarin C on V79 cells was much stronger in the absence of S-9 mix. However, fusarin C did not show, at the largest concentration used, any significant mutagenic or clastogenic effect on the cells without the addition of S-9 mix. The possible relationship between the consumption of corn contaminated with F. moniliforme and the cause of esophageal cancer was discussed.

Animals↗
PubMed1985

[Studies on a new mutagen produced by fusarium moniliforme isolated in Linxian County].

A new mutagen, Fusarin C has been recently isolated and identified from corn meal inoculated with Fusarium moniliforme, one of the most common fungus pollutant of corn in Linxian County, a high-risk area of esophageal cancer. Fusarin C significantly induced sister chromatid exchange (SCE), micronucleus increase, chromosome aberrations, and 6-thioguanine resistant mutants in V 79 cells in the presence of microsomal preparations. Fusarin C also induced 6-thioguanine resistant mutants in V 79 cells cocultured with primary rat liver cells. The toxic action of Fusarin C on V 79 cells was much stronger in the absence of the microsomal preparations. However, Fusarin C did not show, at the highest concentration, any significant mutagenic or chromosomal damage on V 79 cells without the addition of the metabolic activation system. The possible relationship between the consumption of corn contaminated with Fusarium moniliforme and the etiology of esophageal cancer is discussed.

Animals↗
PubMed1981

Promoting effect of Roussin's red identified in pickled vegetables from Linxian China.

Roussin's red (dimethylthiotetranitrosodiiron) has been identified as a non-alkylating N-nitroso compound present in pickled vegetables from Linxian, a high risk area for oesophageal cancer in China. In vitro experiments showed that Roussin's red had no significant mutagenic and transforming activities at the doses used, but it did enhance transformation in C3H/10TI/2 cells initiated with 3-methylcholanthrene (0.1 microgram/mI) and it decreased the number of sebaceous glands and increased the epidermal thickness in short term skin tests. In this respect Roussin's red resembled 12-O-tetradecanoyl-phorbol-13-acetate and the results indicate that it may be a new naturally-occurring tumour promoter. The in vitro promoting effect of extracts of pickled vegetables that has been previously reported can be explained, at least in part, by the presence of Roussin's red. The possible role of Roussin's red in the aetiology of oesophageal cancer is discussed.

Animals↗
PubMed1980

Mutagenic, transforming and promoting effect of pickled vegetables from Linxian county, China.

A recent epidemiological survey in China showed that there is a regional distribution of esophageal cancer and a correlation between mortality for this cancer and environmental factors, especially the consumption of pickled vegetables. A series of experimental studies with pickled vegetable extract were done using different in vitro biological systems. The results showed that pickled vegetable extract induced 6-thioguanine-resistant mutants in V79 cells and increased sister chromatid exchanges in the same cells and in Syrian hamster embryo cells. Pickled vegetables extract induced transformed foci in Syrian hamster embryo cells and in 3-methylcholanthrene initiated C3H/10T1/2 cells. The mutagenic, transforming and promoting activities of pickled vegetable extract seen in vitro conform with in vivo results and provide evidence for the presence of a mutagen and/or a carcinogen in pickled vegetable extract. A possible role of pickled vegetables consumption in the etiology of esophageal cancer is discussed.

Animals↗
PubMedDate not supplied

Congenital nasal pyriform aperture stenosis and single central maxillary incisor: CT and MRI findings.

The authors report five cases of congenital nasal pyriform aperture stenosis (CNPAS). Four cases are presented as neonatal nasal obstruction and also have single central maxillary incisor (SCMI). Computed tomography examination indicates three of the SCMI are unerupted and one is erupted. The fifth case has an erupted SCMI and short stature. The associated SCMI in CNPAS is believed to be more than an isolated anomaly. Awareness of the associated features of CNPAS among the radiologist and otolaryngologist may help the diagnosis and treatment of the patient.

Abnormalities, Multiple↗