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S J Fleming

Publications and source records attributed to S J Fleming.

45 records · Page 3Linked to original sources

Influence of intraperitoneal dialyzate on blood pressure during continuous ambulatory peritoneal dialysis.

Blood pressure (BP) of patients on continuous ambulatory peritoneal dialysis (CAPD) must be well controlled. The present study tests a clinical impression that BP recordings are higher with dialyzate within the peritoneal cavity than after it is drained out. 8 CAPD patients had systolic BP, diastolic BP and heart rate measured both with dialyzate in situ and after drainage. Paired t-tests showed systolic BP and diastolic BP but not heart rate to be significantly (P less than 0.05) higher with dialyzate in situ. To avoid a false impression of good BP control it is recommended patients on CAPD measure BP with dialyzate in situ.

Adult↗

In vitro pairing of Echinostoma revolutum (trematoda) metacercariae and adults, and characterization of worm products involved in chemoattraction.

In vitro pairing studies were done on chemically excysted metacercariae and on adults of Echinostoma revolutum maintained in vitro in agar-Locke's petri dish cultures at 39 +/- 1 C for up to 24 hr. Whereas newly excysted metacercariae did not pair, both immature and mature adults showed significant pairing. Adult echinostomes confined in dialysis sacs emitted excretory-secretory (EC) products which significantly attracted single echinostome adults in vitro. Only the lipophilic fraction of ES products was found to elicit attraction. Preparative TLC analysis of adult echinostomes produced three major bands as follows: I (phospholipids); II (free sterols); and III (free fatty acids + triglycerides). When tested in vitro, only the free sterol fraction significantly attracted single adult echinostomes. TLC and GLC analyses of free sterols of E. revolutum have indicated that cholesterol is the major free sterol.

Animals↗

Testing hearing.

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Audiometry↗

Acute lowering of plasma oncotic pressure increases filtration fraction and sodium excretion in conscious sheep.

We examined the effect of acutely lowering the colloid osmotic pressure by removing plasma (36.2 +/- 3.1 ml/kg) and replacing it with Hartmann's solution (93.0 +/- 8.2 ml/kg) in 6 conscious merino sheep. The colloid osmotic pressure was reduced significantly (p < 0.05) from 20.3 +/- 0.9 to 8.5 +/- 2.5 mm Hg 0 h after plasmapheresis and to 15.2 +/- 0.8 mm Hg 20 h after treatment. The filtration fraction increased from 0.16 +/- 0.02 to 0.27 +/- 0.02 at 0 h (p < 0.05 vs. control) and to 0.20 +/- 0.02 at 20 h after treatment (p < 0.05 vs. control). At 0 h after plasmapheresis, there was an increase in both sodium excretion from 187 +/- 69 to 459 +/- 82 mumol.min-1 (p < 0.05) and in fractional sodium excretion from 1.6 +/- 0.4 to 4.4 +/- 1.0% (p < 0.05). The results are consistent with the hypothesis that acute alteration of Starling forces produce clinically significant effects on both glomerular filtration and tubular reabsorption.

Animals↗