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S J Fowler

Publications and source records attributed to S J Fowler.

21 records · Page 2Linked to original sources
PubMed1988

Individual specific DNA fingerprints from a hypervariable region probe: alpha-globin 3'HVR.

A probe detecting a hypervariable region (HVR) 3' to the alpha globin locus on chromosome 16 has been used to produce DNA fingerprints. Segregation analysis has revealed multiple, randomly dispersed DNA fragments inherited in a Mendelian fashion with minimal allelism and linkage. The fingerprints are highly polymorphic (probability of chance association between random individuals much less than 10(-14]. The probe is, therefore, a powerful discriminating tool: it is envisaged that this probe will have forensic applications, including paternity cases, and will be informative in linkage analysis.

Alleles↗
PubMed1975

Ontogeny of thermoregulatory mechanisms in the rat.

The ability of rats to select a warm environment was studied as a function of postnatal age (birth to 13 days). Animals younger than 5 days demonstrated no choice response (movement to a warm compartment, 36-37 degrees C); however, they did demonstrate movement within the start compartment (23 degrees C). Increasing the motor capabilities of the pups, by injection of L-3,4 dihydroxyphenylalanine (L-dopa, 50 mg/kg), elicited a choice response in 4-5 day-old animals. Younger animals demonstrated no choice of a warm environment even though they moved considerably. Also there was no difference between L-dopa-treated and control animals in the magnitude of temperature change in pups isolated from their mother for 1 hr. The evidence suggests development of behavioral thermoregulatory mechanisms prior to abilities for internal regulation.

Age Factors↗