PubMed Health⌕ Search

Biomedical subjects

S J Hawkes

Publications and source records attributed to S J Hawkes.

5 recordsLinked to original sources
PubMed2006

Herpes simplex virus type 2: epidemiology and management options in developing countries.

Genital herpes simplex virus type 2 (HSV2) is highly prevalent worldwide and an increasingly important cause of genital ulcer disease (GUD). Continued HSV2 transmission is facilitated by the large number of undiagnosed cases, the frequency of atypical disease and the occurrence of asymptomatic shedding. The lack of easy, affordable diagnostic methods and specific antiviral treatment in countries with low and middle income is of great concern, given the ability of GUD to enhance HIV transmission and acquisition. With rising HSV2 prevalence contributing to an increase in the proportion of GUD attributed to genital herpes in high-HIV prevalence settings, a safe and effective HSV vaccine is urgently needed. Meanwhile, multifaceted interventions are required to improve recognition of genital herpes, to prevent its spread and also to prevent its potential to promote HIV transmission in developing countries.

Antiviral Agents↗
PubMed2006

Radiological characterisation of photon radiation from ultra-high-intensity laser-plasma and nuclear interactions.

With the increasing number of multi-terawatt (10(12) W) and petawatt (10(15) W) laser interaction facilities being built, the need for a detailed understanding of the potential radiological hazards is required and their impact on personnel is of major concern. Experiments at a number of facilities are being undertaken to achieve this aim. This paper describes the recent work completed on the Vulcan petawatt laser system at the CCLRC Rutherford Appleton Laboratory, where photon doses of up to 43 mSv at 1 m per shot have been measured during commissioning studies. It also overviews the shielding in place on the facility in order to comply with the Ionising Radiation Regulations 1999 (IRR99), maintaining a dose to personnel of less than 1 mSv yr(-1) and as low as reasonably practicable (ALARP).

Humans↗
PubMed1993

Travel, migration and HIV.

This is a review of recent publications on the subject of travel (taken in its widest sense) and HIV/AIDS. As with all epidemics caused by transmissible pathogens, AIDS has been seen in many countries as an imported problem. What this perspective fails to recognize is that with the explosion of international travel in the past thirty years it is virtually impossible to prevent the spread of infectious disease across international frontiers. Here we highlight the relative paucity of studies that describe or investigate the context in which sexual risk behaviour of travellers takes place, and suggest areas of further research which could increase understanding of the nature of sexual risk taking, and help in the design of health education programmes.

Cross-Cultural Comparison↗
PubMed1986

Liver glycogenolysis during exercise in adrenodemedullated male and female rats.

Previous studies have shown that adrenodemedullation has no effect on the rate of liver glycogenolysis during exercise in male rats. Mature female rats have been reported to have a higher hepatic beta-adrenergic receptor activity than do male rats of the same age. The present study was undertaken to determine the role of plasma epinephrine in stimulating liver glycogenolysis during exercise in female rats. Both male and female rats were adrenodemedullated or sham operated. Three weeks later rats were run for 60 min at 21 m/min up a 15% grade. The rate of liver glycogenolysis during exercise was not affected by adrenodemedullation in either female rats or male rats. Hepatic adenosine 3',5'-cyclic monophosphate increased to approximately the same extent in sham operated as in adrenodemedullated female rats during exercise. Adrenodemedullation caused a significant reduction in the amount of glycogen utilized by the soleus muscle and in the degree of hyperglycemia during exercise. We conclude that epinephrine is unessential for stimulation of liver glycogenolysis during exercise in either male or female rats.

Adrenal Medulla↗