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Biomedical subjects

S J Hutt

Publications and source records attributed to S J Hutt.

5 recordsLinked to original sources

Sensorimotor rhythm feedback training and epilepsy: some methodological and conceptual issues.

This study examined the hypothesis that the enhancement of a 12-16 Hz sensorimotor rhythm in the EEG is inhibitory to epileptic seizure activity. The effects of training to enhance 12-16 Hz central EEG, to enhance 8-10 Hz central EEG, to suppress high voltage EEG activity, and of random feedback were compared over a period of 12 months in three adult patients suffering from chronic, drug-refractory epilepsy. All three patients experienced a significant reduction in seizure rate by the end of the study, but this was not related to any one particular training condition. It is suggested that the therapeutic mechanism might involve placebo effects, relaxation training, or a facilitation of EEG desynchronization, the effect being idiosyncratic to the individual patient.

Adult

Prenatal progesterone. I. Its effect on development and on intellectual and academic achievement.

The development of two groups of children whose mothers had been given progesterone supplements during pregnancy to relieve symptoms of toxaemia was assessed, one group at 2 yr of age and the other at 16 yr of age. There was no evidence that progesterone supplements accelerated development in the 2-yr-old age group or enhanced intellectual and academic attainment in the 16-yr-old age group. In addition, the evidence regarding the reported beneficial effects on intellectual attainment of in utero exposure to excess sex steroids is discussed.

Achievement

Information processing during two types of EEG activity.

A 15-year-old girl whose EEG contained frequent bursts of generalized sub-clinical spikewave activity was examined on a paced serial-choice response task with simultaneous EEG control. The task was carried out at three different speeds and three different information loads. Performance was compared during paroxysms of spike-wave activity and during normal EEG background activity. Four parameters of performance were compared, each parameter being somewhat differently affected by spike-wave activity. "Response ambiguity" was significantly increased in the presence of spike-wave activity, with a corresponding decrease in the amount of "information transmitted". The "absolute rate" at which information could be transmitted in relation to presentation rate was consequently reduced during spike-wave activity, the effect being most marked at the intermediate speed of presentation (1 signal/2 sec). However, when signals were presented very slowly (1/4 sec) the child's "relative information transmitted" during spike-wave activity approached that achieved under normal background conditions. Thus, accuracy of performance per se is not critically affected by spike-wave; rather it is the rate at which signals can be handled. Spike-wave may therefore be conceptualized as a form of "neural noise" whose effect is to reduce a subject's channel capacity.

Adolescent