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S J Insalaco

Publications and source records attributed to S J Insalaco.

10 recordsLinked to original sources
PubMed1992

Amphicrine carcinoma of the uterine cervix.

A case of amphicrine carcinoma of the uterine cervix is described in a 27-year-old woman whose initial cervical biopsy specimen showed small cell undifferentiated neuroendocrine carcinoma. Despite an initial complete clinical response to VP-16 and carboplatin, residual tumor was noted in the cervical cone biopsy specimen and she was treated with external-beam irradiation and cesium implants. The neoplasm subsequently metastasized and required additional VP-16 and carboplatin for control. The pathologic features and biologic behavior of this unusual type of neuroendocrine neoplasm are described in this case report.

Adult↗
PubMed1985

Unilateral ureteral obstruction secondary to sarcoidosis.

An episode of unilateral ureteral obstruction secondary to sarcoidosis is described. Corticosteroid treatment resulted in prompt and complete resolution of the obstruction and associated lymphadenopathy. We believe this represents the first reported case of ureteral obstruction secondary to sarcoidosis.

Adult↗
PubMed1984

Postmortem methemoglobin concentrations and their significance.

Small concentrations of methemoglobin are present in the blood of normal individuals. Increased concentrations of methemoglobin can be formed by the action of certain chemicals or drugs, or in individuals with specific genetic defects. There is little information available concerning the validity of postmortem methemoglobin concentration as an indicator of antemortem methemoglobinemia. We measured blood concentrations of methemoglobin in 49 autopsy specimens. We conclude that postmortem methemoglobin concentrations are not valid indicators of antemortem methemoglobinemia.

Adolescent↗
PubMed1983

Stage A prostatic carcinoma and repeat transurethral resection: a reappraisal 5 years later.

The treatment of patients with stage A prostatic carcinoma demands precise pathological review. In an attempt to evaluate these patients thoroughly earlier reports from our institution recommended repeat transurethral biopsy. Recent studies have reaffirmed the benign nature of stage A1 disease. To examine the efficacy of this procedure a referee pathologist reviewed 8 years of experience with patients with stage A prostatic carcinoma from our institution. Clinical followup was more than 5 years in most cases. Of the 40 patients who underwent repeat transurethral biopsy the tumor in 38 remained stage A1 pathologically. While 1 patient died of the tumor the the remainder are without clinical disease. This low incidence of upstaging does not support the routine use of repeat resections.

Aged↗
PubMed1982

Benign testis tumors.

Benign testis tumors are reported to be extraordinarily rare. Recent clinical experience has shown a high prevalence (7 of 12 patients) of these tumors, which, although small, is much higher than other reports. We herein present 4 illustrative cases and a practical categorization of the varied pathologic events causing these tumors.

Adult↗
PubMed1981

"Carcinoid" tumor of the breast. A variant of conventional breast cancer?

A breast tumor with the morphologic features of a carcinoid tumor and containing large amounts of estrogen receptor protein was associated with areas of typical in situ and infiltrating lobular carcinoma. The carcinoid areas were argyrophilic and ultrastructurally contained electron dense granules on which silver grains were localized. Of 21 other examples of ordinary breast cancer, five showed histologic similarities to carcinoid tumors. Focal argyrophilia was observed in 11 invasive tumors. The presence of argyrophilic granules could not be correlated with the presence of "neurosecretory" granules, although groups of such granules were found in one case of in situ lobular carcinoma. Argyrophilic and "neurosecretory" granules imply the presence of hormonal substances, although in breast tumors these granules have not yet been chemically or immunochemically characterized. Until such evidence becomes available it would appear that most cases reported as primary carcinoid tumors of the breast have much more in common with conventional breast cancer than with the usual carcinoid tumor. Within this context it can be acknowledged that some breast cancers may focally exhibit a carcinoid-like differentiation.

Aged↗
PubMed1981

Acute lymphocytic leukemia with prominent azurophilic granulation and punctate acidic nonspecific esterase and phosphatase activity.

Cytochemical, ultrastructural, and terminal deoxynucleotidyl transferase determinations in three cases of acute lymphocytic leukemia with azurophilic granules and punctate alpha-naphthyl acetate esterase (ANAE), alpha-naphthyl butyrate esterase (ANBE), and acid phosphatase (AP) activities further described a cytochemical and morphologic variant of acute lymphocytic leukemia. The ANAE, ANBE, and AP activities appeared specially localized within cytoplasmic granules. Electron microscopy substantiated a prominence of membrane-bound dense-core cytoplasmic granules. The variegated appearance of these dense-core granules and the cytochemical profile suggest that the aberrant granules are lysosomal in nature. Both the prominent cytoplasmic granules and the older age distribution led to early misdiagnosis of myelocytic leukemia. The distinctive cytochemical/morphologic profile and the ease of misdiagnosis suggest an important morphologic variant of acute lymphocytic leukemia.

Adolescent↗
PubMed1980

"Melanosis" of the duodenum associated with a gastric ulcer and folic acid deficiency.

Melanosis involving the duodenum is extremely rare. We present endoscopic, microscopic, and histochemical studies of a patient with melanosis of the duodenum associated with a gastric ulcer and a folic acid deficiency. The pigment is similar to that observed in melanosis coli and histochemically does not stain like melanin or lipofuscin. The pigment disappeared with correction of the folate deficiency and healing of the gastric ulcer, suggesting a possible relationship with these entities.

Aged↗