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Biomedical subjects

S J Kilpatrick

Publications and source records attributed to S J Kilpatrick.

At least 55 records · Page 3Linked to original sources
PubMed1986

Role of Ca 125 as tumor marker in ovarian carcinoma.

Thirty-three healthy women (group 1), 20 patients with a history of ovarian carcinoma but no manifest disease at the time of the study (group 2), and 45 patients with surgically demonstrable ovarian cancer (group 3) were studied to establish guidelines for the use of the ovarian cancer antigen Ca 125 in monitoring the course of ovarian carcinoma. Ninety-nine percent of all Ca 125 titers of patients in groups 1 and 2 were less than or equal to 25 U/mL. By contrast, 96% of patients with manifest ovarian cancer had Ca 125 levels greater than 25 U/mL. Ca 125 values rising from the normal range to greater than 25 U/mL predicted recurrent disease in all of ten patients, provided benign causes (four cases) for titer elevations such as bowel obstruction could be ruled out. Seven of ten patients with recurrent cancer had elevated antigen levels two to five months before the diagnosis could be made clinically. In patients with Ca 125 values greater than 25 U/mL, titer changes of greater than or equal to 50% compared with reference values predicted tumor response or progression in 41 of 43 patients (95%) with antigen positive tumors. Antigen levels less than or equal to 25 U/mL did not exclude the presence of tumor at second look operation in six of 13 patients (46%). It is concluded that the Ca 125 is useful for the detection of persistent and recurrent disease, and for the evaluation of treatment responses.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMed1985

Prostaglandins and nicotinate-provoked increase in cutaneous blood flow.

The mechanism of topically applied methyl nicotinate-induced local cutaneous erythema was studied in normal human subjects. Aqueous methyl nicotinate (0, 0.1, 1.0, 10.0, and 100 mmol/L) was applied to the volar forearms in quadruplicate after oral pretreatments with 25 mg doxepin hydrochloride, 600 mg ibuprofen, 50 mg indomethacin, 975 mg aspirin, and lactose placebo. The cutaneous vascular response was monitored by laser Doppler velocimetry. Although doxepin did not affect the cutaneous vascular response to methyl nicotinate, indomethacin, ibuprofen, and aspirin significantly suppressed the response. Because indomethacin, ibuprofen, and aspirin have different chemical structures, the common property of inhibition of the response to methyl nicotinate may be assigned to their common pharmacologic action, i.e., inhibition of prostaglandin bioformation.

Administration, Oral↗
PubMed1983

The maternal pheromone of the rat: testing some assumptions underlying a hypothesis.

Herein we report four experiments relating to the maternal pheromone of the rat that show (a) preweanling young consume pheromone-containing feces most conspicuously between 14 and 27 days; (b) they consume those feces preferentially; (c) such feces contain high levels of deoxycholic acid; and (d) preweanling young are deficient in deoxycholic acid. The data of these experiments lend support to the hypothesis that in responding to the pheromone the young ingest deoxycholic acid, a steroid believed to promote gut immunocompetence and brain myelination.

Animals↗
PubMed1982

The effect of estrogen and progesterone on beta-adrenergic receptor activity in rabbit lung tissue.

Study of the effect of sex steroids on the development of beta-adrenergic receptors may be essential to an understanding of the mechanisms of both lung maturation and the initiation of labor. (3H)Dihydroalprenolol (DHA) was used to quantify beta-adrenergic receptor sites in mature and immature rabbit lung tissue. DHA binding was rapid, saturable, of high affinity (dissociation constant = 2 nM), and of low capacity (246 to 576 fmoles/mg of protein), and a adrenergic competitors demonstrated both stereoselectivity ([-]isomer much greater than [+]isomer) and a rank order of potency (isoproterenol much greater than norepinephrine greater than epinephrine) characteristic of the beta-adrenergic receptor. beta-Adrenergic receptors in the lung tissue of both mature and immature female New Zealand White rabbits were investigated under various sex steroid situations. Estrogen (diethylstilbestrol, 5 micrograms/day for 10 days) increased the beta-adrenergic receptor site number in immature rabbits compared to matched controls (435 versus 339 fmoles/mg of protein, p less than 0.02 by paired t test). Addition of progesterone (diethylstilbestrol, 5 micrograms/day for 10 days, plus progesterone, 5 mg/day for 3 days) returned the beta-adrenergic receptor site number to control values (321 fmoles/mg of protein, p less than 0.01). In mature rabbits, treatment with progesterone alone (10 mg/day for 4 days) caused a significant reduction in beta-adrenergic receptor site numbers compared to untreated, matched controls (357 versus 493 fmoles/mg of protein, p less than 0.05 by paired t test). in the presence of estrogen, beta-adrenergic receptor activity is enhanced in both mature and immature rabbit lung tissue. Addition of progesterone restores this activity to control values.

Animals↗
PubMed1982

Manipulation of testosterone in the neonatal rat and pheromonal emission in the adult.

The question we addressed is why the male rat fails to emit the maternal pheromone when caring for young or when injected with prolactin. Our hypothesis was that exposure to androgen neonatally decreases the prolactin sensitivity of the male liver, making that liver incapable of secreting sufficient cholic acid for pheromonal synthesis. Accordingly, we castrated male rats prior to 2 hr of age and injected female rats with testosterone propionate within 8 days of age. Only those animals that had been spared exposure to androgen neonatally showed evidence of the pheromone when injected with prolactin as adults. Moreover, these same animals exhibited a higher output of cholic acid per g liver than their control counterparts (sham-operated males and vehicle-injected females). We conclude that the sex-related capacity for pheromonal emission is differentiated perinatally and involves the sensitivity of the liver to prolactin and its consequent secretion of cholic acid.

Animals↗
PubMed1980

The maternal pheromone and bile acids in the lactating rat.

Bile was drawn from virgin rats and from postpartum rats that were with young for 5, 12, 21, and 30 days, respectively. The bile thus drawn was analyzed enzymatically after chromatographic separation to test an hypothesis relating cholic acid and one of its metabolites, deoxycholic acid, to the appearance of the maternal pheromone. Our finding that cholic acid, but not deoxycholic acid, reached a peak that was tied specifically to the period of pheromonal emission led us to advance a revised hypothesis. We now think that cholic acid alone, or more likely a cholic metabolite other than deoxycholic acid, underlies the appearance of the pheromone.

Animals↗
PubMed1977

Consultation frequencies in general practice.

Some models of the process by which individuals seek medical care suggest the negative binomial as the underlying distribution of the frequencies of consultations in a given practice. Data from the 1970-71 National Morbidity Survey of General Practice are used to test these competing models. It is shown that the negative binomial distribution successfully fits consultation frequencies in aggregate and in subdivisions according to age, sex, and duration of registration. In this article is is assumed that the consultation process has two components: the patient's decision to visit his doctor for a new illness and the follow-up visits that results from this new problem. Supplementing previous evidence that the distribution of episodes of new illnesses follows a negative binomial distribution, this article shows that consultation frequencies among individuals presenting with one new illness also follow a negative binomial distribution. A unifying model is required to synthesize these findings.

Adolescent↗