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Biomedical subjects

S J LaBrooy

Publications and source records attributed to S J LaBrooy.

10 recordsLinked to original sources
PubMed1987

Increase in bile secretion after water ingestion in cholecystectomised patients.

The effect of water ingestion on bile secretion was investigated in nine cholecystectomised patients with T-tube biliary drainage. The effect of ingestion of a standard meal on bile secretion was also studied in these patients. Water ingestion produced a significant increase in bile secretion compared with fasting levels. This increase in bile secretion was comparable to that produced by a standard meal. Ingestion of water or meal did not produce any significant change in bile osmolality or sodium and potassium concentrations of bile.

Aged↗
PubMed1983

Medical management of gastric ulcer.

The aetiopathogenesis of gastric ulceration suggests that though gastric acid plays an essential role, damage to the gastric mucosal barrier may be of more importance. Gastric ulceration is a complex disease and certain factors such as the size and site of the ulceration may influence healing. If these are not carefully standardised assessment of various therapeutic agents may produce conflicting results. The factor which has perhaps most influenced the approach to therapy of gastric ulcers is the difficulty in differentiating benign from malignant ulceration. The first accepted form of treatment for gastric ulceration was carbenoxolone sodium and though a high incidence of side effects were reported with its use, it enabled treatment on an outpatient basis. More recently the histamine H2-receptor antagonists have been shown to be equally effective and minimal reported adverse effects have made them the treatment of choice. Newer drugs are available but are yet to be fully evaluated. At present maintenance therapy is not advisable in patients with gastric ulceration unless the risk of relapse in these patients outweighs the danger of delaying diagnosis of malignancy. Where maintenance therapy is used patients should be closely monitored clinically and endoscopically.

Aged↗
PubMed1983

Gastritis and duodenitis--a clinical, endoscopic and histological study and review of the literature.

A clinical, endoscopic and histological study of gastritis and duodenitis was carried out in 50 patients. The endoscopic diagnosis of mucosal inflammation was found to be highly reproducible. However there was poor correlation between endoscopic and histological diagnoses of gastritis or duodenitis. Neither endoscopic nor histological gastritis or duodenitis correlated with symptoms. These findings are in agreement with others reported in the literature. Gastritis and duodenitis should not be diagnosed by history alone but only by endoscopy or histology. When gastritis or duodenitis is the only pathology demonstrated only symptomatic therapy should be given. The literature on the diagnosis and aetiology of gastritis as well as that of specific varieties of gastritis is reviewed.

Adult↗
PubMed1983

The influence of sex, race and dialect on peptic ulcer and non-ulcer dyspepsia in Singapore.

A consecutive series of 2,277 patients presenting for upper gastrointestinal endoscopy was analysed. The following groups of patients were studied with reference to sex, race and dialect groups: those presenting with dyspepsia but no haemorrhage, those presenting with upper gastrointestinal haemorrhage, those with non-ulcer dyspepsia, gastric ulcer and duodenal ulcer. Males out-numbered females in all diagnostic groups. Male and female Malays were under-represented in all diagnostic groups when compared to the Singapore population. Amongst female Chinese, there was an excess of Cantonese patients and an under-representation of Teochew patients in most diagnostic groups. These dialect differences were not remarkable amongst male Chinese. The possible reasons for these differences and their significance are discussed.

Adolescent↗
PubMed1983

Psychological characteristics of duodenal ulcer patients (a pilot report on 30 patients).

A psychological investigation of 30 duodenal ulcer patients showed that their profile differed from that of the Western patients in that drinking, smoking, anxiety, depression and psychopathy were not more common than in the general population. Psychological stress as measured by recent life events was low, but 40% had complaints relating to their work. Their scores for Friedman's Type A Behavior as measured by the Bortner's Scale was low. They had a high Lie Score for the Eysenck Personality Inventory indicating a desire to project a socially desirable image.

Adult↗
PubMed1981

Investigations on the penetration of ranitidine into the cerebrospinal fluid and a comparison of the effects of ranitidine and cimetidine on male sex hormones.

Cerebrospinal fluid (CSF) ranitidine concentrations were measured in 13 normal subjects undergoing routine myelography following either one, or two doses ranitidine 200 mg. Small amounts of the drug were detectable in the CSF. A separate investigation of duodenal ulcer patients compared the effects of ranitidine 150 mg twice-daily and cimetidine 1 g daily on basal and stimulated levels of male reproductive hormones in the plasma. Although cimetidine treatment resulted in a small rise in basal and stimulated testosterone, neither drug was associated with significant changes in basal or stimulated hormone levels.

Adult↗