Distribution and excretion of 3H-venoms of Crotalus adamanteus, Crotalusatrox, and Agkistrodon piscivorus and 3H-serum of Lampropeltis getulus in rats.
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Animals↗
Biomedical subjects
S J Liu
Publications and source records attributed to S J Liu.
The crystal and molecular structure of the barium salt of an antibiotic containing a high proportion of oxygen.
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Anti-Bacterial Agents↗
The acute oral toxicity of parathion in relation to dietary protein.
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Animals↗
The acute oral toxicity of parathion in relation to dietary protein.
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Animals↗
Toxicity of starch administered by mouth.
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Animal Nutritional Physiological Phenomena↗
Substance P-immunoreactive nerve fibres in the pars distalis of the anterior pituitary of macaques.
The anterior pituitary glands of Macaca mulatta and M. assamensis were stained with antiserum against substance P (SP). A substantial amount of SP-immunoreactive (ir) nerve fibres with numerous varicosities were found in the pars distalis of the anterior pituitary. They were located in the median part of the gland and were distributed mainly in its dorso-posterior region. The great majority of the varicosities were found to be related to the glandular tissue, although some apparently were located along the walls of the blood sinuses. In addition, many SP-ir cells, mostly large and oval, were distributed at the periphery of the gland. In areas where both SP-ir nerve fibres and cells were present, many cells were found to be in close proximity to the nerve fibres.
Animals↗
Effects of phenobarbital and SKF 525-A on the in vivo metabolism of morphine in rats.
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Animals↗
Brain and plasma levels of methadone and their relationships to analgesic activity of methadone in rats.
The levels of methadone in brain and plasma of rats after acute administration of several different doses of methadone were measured at several time points and relationships to analgesic activity were examined. Both brain and plasma levels of methadone as well as the analgesic activity of methadone, expressed as analgesic area and as percentage of maximum possible effect, were all increased by increasing dosage. All these measurements dropped rapidly after reaching the peak levels 30 min after administration of methadone. At the time of maximal analgesia, the analgesic effect of methadone was quantitatively related to both brain and plasma levels of methadone with 50% of the analgesic maximum possible effect corresponding to the concentrations of 1.44 nmol/g and 0.52 nmol/ml of methadone in brain and plasma, respectively. Our data suggest that measurement of changes in the plasma concentration of methadone at the time of maximal analgesia reflects changes in the brain concentration of methadone and may provide an index of changes in the analgesic effect of methadone.
Analgesics, Opioid↗