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Biomedical subjects

S J Mann

Publications and source records attributed to S J Mann.

47 records · Page 3Linked to original sources
PubMed1972

Inheritance of hair constrictions in mice.

The frequencies of multi-constricted hairs in the pelage is the same (75%) in the caudal mid-dorsum of C57BL/10 and CBA inbred mice, but there are more single-constricted hairs in C57BL mice (9.41%) than in CBA mice (0.13%). This structural feature is used as a basis for genetic analysis of the hair coat.-The frequency of single-constricted hairs (4.41%) in F(1) mice is intermediate between the frequencies observed in the CBA and C57BL parent strains. Data from the F(2) crosses and backcrosses to the respective parent strains indicate that the presence of numerous single-constricted hairs in the pelage is an inherited characteristic. The mode of inheritance is controlled primarily by a semi-dominant autosomal gene (single-constriction; Hct), without the involvement of maternal factors.

Animals↗
PubMedDate not supplied

Severe paroxysmal hypertension. An automatic syndrome and its relationship to repressed emotions.

In most patients with severe and symptomatic paroxysmal hypertension, a pheochromocytoma or other medical cause is rarely identified. This article presents the psychosocial assessment of 10 such patients, in whom the absence of any emotional distress preceding paroxysms had discouraged consideration of any psychological basis. However, a causative role of repressed unreported emotions was strongly suggested by 1) a history of unusually severe emotional trauma in 8 of 10 patients, 2) the absence of feelings related to the trauma, and 3) the prompt and sustained response of 3 patients to psychotherapeutic or psychopharmacologic intervention. These observations suggest that some cases of unexplained paroxysmal hypertension have a psychosomatic etiology and result from repressed rather than perceived and reported emotions. Treatment options are explored.

Adult↗
PubMedDate not supplied

Cardiovascular responses to infused epinephrine: effect of the state of physical conditioning.

Arterial pressure and heart rate responses to intravenous infusions of epinephrine at rates of 4-64 ng/kg/min were determined in 15 healthy subjects. The state of physical conditioning in these subjects was assessed by resting (preinfusion) heart rate and bicycle ergometry. Predicted maximal oxygen consumption (pMVO2) was determined by performance at submaximal work loads. Significant correlations were observed between both preinfusion heart rate and pMVO2 and the threshold for the effect of epinephrine on systolic pressure, and the magnitude of the increase in systolic pressure. Neither preinfusion heart rate nor pMVO2 correlated significantly with the chronotropic effect of epinephrine (threshold or absolute increase in heart rate). The pMVO2 and preinfusion heart rate did not correlate significantly with preinfusion venous plasma epinephrine concentration or with plasma levels achieved during infusion. We conclude that physical conditioning increases the effect of circulating epinephrine on systolic arterial pressure without altering the chronotropic effect of this hormone.

Adult↗
PubMedDate not supplied

Improved hypertension control after disclosure of decades-old trauma.

This report presents the case of a 49-year-old woman who had been treated unsuccessfully for 6 years for longstanding severe and refractory essential hypertension. Although she reported no extraordinary stress or distress, her disclosure of a 3-decade-old rape and the experiencing of previously repressed and unconfided emotions related to it were followed by a dramatic and sustained improvement in her blood pressure. This case suggests that repressed emotions, which patients cannot report, may contribute substantially to the development of essential hypertension, even when they are related to decades-old events. More attention to repressed emotions, and better means of studying them, are needed before the mystery of the links between psychological factors and essential hypertension is unraveled.

Adult↗