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Biomedical subjects

S J Tovey

Publications and source records attributed to S J Tovey.

12 recordsLinked to original sources
PubMed1990

Efficacy of ceftizoxime in the treatment of uncomplicated gonorrhoea: comparison with amoxycillin.

Four centres contributed a total of 466 patients to a study comparing the efficacy of oral amoxycillin with that of probenecid and intramuscular ceftizoxime. Both treatments were equally efficacious, except in the small number of penicillinase-producing Neisseria gonorrhoeae patients, all of whom responded to ceftizoxime and none to amoxycyllin. Both treatments were well tolerated, the only two adverse effects occurring in the ceftizoxime group.

Adolescent↗
PubMed1989

Primary and secondary syphilis, 20 years' experience. 2. Clinical features.

The notes of 946 patients with primary and 854 with secondary syphilis were retrospectively reviewed. Of the 184 heterosexual men with primary syphilis, 182 (99%) had chancres affecting the penis, compared with 467 (64%) of the 728 homosexual men (p less than 0.0001). Anorectal chancres occurred in 249 (34%) of homosexual men. The commonest features of secondary syphilis included a rash, lymphadenopathy, and mucous patches of the mouth or genital area. Hepatitis, meningitis, other neurological problems, iridocyclitis, and periostitis were all exceptionally rare. The clinical features of primary and secondary syphilis do not appear to have changed in recent years.

Chancre↗
PubMed1989

Primary and secondary syphilis, 20 years' experience. 3: Diagnosis, treatment, and follow up.

The methods of diagnosis (dark ground microscopy and serology), treatment, and follow up of 946 patients with primary and 854 with secondary syphilis who presented to a London STD clinic between 1965 and 1984 were reviewed retrospectively. On dark ground microscopy spirochaetes typical of Treponema pallidum were seen in 673 (78%) of 884 patients with primary syphilitic chancres. Of the patients with primary syphilis, 137 (14.5%) had negative serology results at presentation. Eight (0.9%) of the patients with secondary syphilis had negative results at presentation, but seven of these gave positive results one month later. Procaine penicillin was the treatment used most, and erythromycin the commonest alternative. The Jarisch-Herxheimer reaction occurred more often after treatment with penicillin than with erythromycin or tetracycline (p less than 0.005). In most patients the Venereal Diseases Research Laboratory (VDRL) test showed a consistent fall in titre after treatment; a small proportion, however, continued to give positive results (some at a high titre) with no other evidence of reinfection or treatment failure.

Erythromycin↗
PubMed1987

Primary and secondary syphilis, 20 years' experience. 1. Epidemiology.

The case notes of 946 patients with primary and 854 with secondary syphilis who attended the department of genitourinary medicine at the Middlesex Hospital in 1965-84 were analysed retrospectively. Most patients were homosexual men, and the proportion of homosexuals showed a significant (p less than 0.0005) upward trend during the study period. There was also a significant upward trend in the percentage of British attenders (p less than 0.0001), as well as an increase in patients in social classes I, II, or III non-manual (p less than 0.0001). Homosexual men had a greater number of sexual partners than heterosexuals or women, and were also more likely to have had a sexually transmitted disease. The proportion of homosexuals with multiple partners showed a significant (p less than 0.0005) upward trend during the study period.

Adolescent↗
PubMed1986

Prevalence of urinary tract infection in homosexual and heterosexual men.

Homosexual practices might be expected to result in an increase in urinary tract infection in adult men. Midstream urine specimens were collected from 200 homosexual and 205 heterosexual men attending a clinic for sexually transmitted diseases. Three specimens from each group yielded more than 10(5) Escherichia coli per ml. The prevalence of urinary tract infection among homosexuals was therefore similar to that in the heterosexual population.

Adult↗
PubMed1977

Hypophosphataemia and phosphorus requirements during intravenous nutrition.

Seven patients with acute illnesses developed hypophosphataemia whilst receiving intravenous nutrition which included a fat emulsion, Intralipid, a possible source of phosphorus. The authors' observations cast doubt on the bio-availability of the phosphorus contained in the phospholipid content of the fat emulsion. The currently recommended allowance of phosphorus for this type of patient appears to be too low and it is suggested that 0-5-0-75 mmol/kg body weight be provided, preferably as a neutral phosphate solution. Sine hypophosphataemia can occur at various time intervals after starting intravenous nutrition and precede clinical sequelae it is recommended that routine serum phosphate measurements are made in all patients receiving this treatment.

Adult↗
PubMedDate not supplied

High cumulative incidence of genital herpes amongst HIV-1 seropositive heterosexuals in south London.

The cumulative incidence of sexually transmitted diseases (STD) in a cohort of 51 (35 female, 16 male) HIV-1 seropositive STD clinic attenders who had acquired HIV-1 infection via heterosexual transmission was investigated through a retrospective review of the case notes. The women were followed up for a mean 11.6 months and the men for 18 months. Thirty-one (88%) of the women and 13 (81%) of the men were of sub-Saharan African origin. Approximately half of the subjects were first diagnosed as HIV-1 positive with CD4 counts < 200 x 10(6)/1 and a quarter with CD4 counts < 50 x 10(6)/1. STDs detected in women were: genital herpes 15 (43%), candida 12 (34%), bacterial vaginosis 9 (25%), and in men: genital herpes 6 (38%), non-gonococcal urethritis 4 (25%). No cases of gonorrhoea were detected. At the time of first diagnosis of genital herpes at the clinic, the mean CD4 count in women was 275 x 10(6)/1 and in men 285 x 10(6)/1. Genital herpes was the AIDS defining diagnosis in 3 of the women. The recognized risk of HIV transmission via genital lesions should be stressed in HIV-1 positive subjects with genital herpes. The incidence of other STD was low--both knowledge of HIV status and safer sex counselling may limit unsafe sexual behaviour and should be evaluated further as a strategy for limiting the spread of HIV-1 infection.

Female↗