Cancer chemotherapy in the elderly.
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Aged↗
Biomedical subjects
S J Walsh
Publications and source records attributed to S J Walsh.
Arboviruses recovered from sentinel livestock in northern Australia.
Over 700 arboviruses were recovered between 1981 and 1987 from the blood of sentinel livestock near Darwin. Twenty-three isolates were made from sheep, goats, swamp buffalo (Bubalus bubalis) and horses, and the remainder were from cattle. The isolates have been typed as 27 separate viruses belonging to the bluetongue, epizootic haemorrhagic disease, Palyam, Simbu, bovine ephemeral fever, Tibrogargan and alphavirus groups. Ten of these viruses have not been isolated elsewhere in Australia and four have been isolated only in Darwin. Considerable annual variations in virus activity and in the durations of detectable viraemia were observed.
Animals↗
Arboviruses recovered from sentinel cattle using several virus isolation methods.
A group of 20 sentinel steers was bled weekly for 5 months in 1986 and the blood samples were examined for arboviruses by inoculation firstly into embryonated chicken eggs (ECE), baby mice, Aedes albopictus cells and BHK21 monolayers. A second group of cattle was similarly examined for virus in 1987, except that baby mice were not used. Viruses were recovered from 26% of the 878 weekly bleeds. The viruses identified consisted of 14 types belonging to the bluetongue, epizootic haemorrhagic disease (EHD), Palyam and Simbu groups with a single isolation of bovine ephemeral fever virus. The ECE system was found to be the best for isolating bluetongue and Simbu viruses, though the eggs were not usually killed by the inoculum. The ECE and A. albopictus systems were equally sensitive for recovering EHD viruses, while Palyam group viruses were most efficiently isolated in BHK21 monolayers.
Animals↗
The New Zealand DNA databank: its development and significance as a crime solving tool.
The New Zealand DNA Databank was established following the introduction of legislation in August 1996. Using the Second Generation Multiplex (SGM), DNA profiles from over 13,000 convicted offenders and volunteer donors have been completed to the National DNA Database. Since June 1998, DNA profiles from over 1,400 unsolved crimes have been entered onto the Crime Sample Database. Of all unsolved crimes analysed, 33% are linked to individuals and 21% are linked to other unsolved crimes. Several high profile types of case including homicides, sexual offenses and burglaries are amongst those regularly solved.
Crime↗
The collation of forensic DNA case data into a multi-dimensional intelligence database.
The primary aim of any DNA Database is to link individuals to unsolved offenses and unsolved offenses to each other via DNA profiling. This aim has been successfully realised during the operation of the New Zealand (NZ) DNA Databank over the past five years. The DNA Intelligence Project (DIP), a collaborative project involving NZ forensic and law enforcement agencies, interrogated the forensic case data held on the NZ DNA databank and collated it into a functional intelligence database. This database has been used to identify significant trends which direct Police and forensic personnel towards the most appropriate use of DNA technology. Intelligence is being provided in areas such as the level of usage of DNA techniques in criminal investigation, the relative success of crime scene samples and the geographical distribution of crimes. The DIP has broadened the dimensions of the information offered through the NZ DNA Databank and has furthered the understanding and investigative capability of both Police and forensic scientists. The outcomes of this research fit soundly with the current policies of 'intelligence led policing', which are being adopted by Police jurisdictions locally and overseas.
Databases, Nucleic Acid↗
Goodness-of-fit issues in ROC curve estimation.
Zhou recently considered goodness-of-fit (GOF) testing for receiver operating characteristic (ROC) curves estimated by applying the binormal and other bidistributional models to rating method data. He interpreted significant GOF tests as evidence that different decision thresholds were applied to diseased and nondiseased subjects and concluded that, in such circumstances, an ROC curve does not exist. In this article the author demonstrates that the GOF test accommodates many alternative hypotheses and that a significant test result need not be equated with an interaction between disease status and decision criteria or with non-existence of an ROC curve. He develops a new family of ROC curves based on a fully parameterized bidistributional model. The family includes the binormal ROC curve, but generalizes its structure by signifying all identifiable deviations in parameters of the latent distributions that define the model. The family provides a unified framework of alternative models to the binormal assumption and of alternative hypotheses to the GOF test for that assumption.
Binomial Distribution↗
Hepatitis B vaccine responsiveness in Connecticut public safety personnel.
OBJECTIVE: To determine the level and determinants of vaccine response in recently inoculated public safety personnel. DESIGN: Prevalence survey. PARTICIPANTS: Public safety personnel who had completed vaccination 1 to 6 months prior to testing and had no serological evidence of previous exposure to hepatitis B virus. MAIN OUTCOME MEASURE: An inadequate level of antibody to hepatitis B surface antigen was defined as less than 10 mlU/mL. RESULTS: All subjects in the study had been vaccinated using Recombivax HB, a recombinant hepatitis B vaccine. Of 528 individuals, 11.9% were found to have no or inadequate levels of antibody. The frequency of inadequate level of antibody increased significantly relative to age, from 2.8% among those younger than 30 years to 42.1% among those older than 60 years (P < .0001). Smoking (odds ratio [OR], 3.6; 95% confidence interval [CI], 2.0 to 6.4), extreme obesity (OR, 13.3; 95% CI, 3.8 to 49.1), and increasing time interval since completing the vaccine series (P < .01) were also associated with inadequate levels of antibody. These findings were confirmed by multivariate analysis using logistic regression. CONCLUSIONS: Routine immunization of public safety personnel should include selective use of postvaccine testing. Postvaccination testing optimally should be performed in the 30- to 90-day interval after the last vaccine dose. New vaccination strategies are needed to improve response rates in persons with predictably poor response to hepatitis B vaccine.
Adult↗
Acute staphylococcal osteomyelitis of the clavicle.
Osteomyelitis of the clavicle is a rare condition that is difficult to diagnose. We have reviewed five cases of acute staphylococcal osteomyelitis of the clavicle that have been collected over a 3-year period in our center. All patients had pain, fever, and swelling over the clavicle. All had a raised erythrocyte sedimentation rate with positive Staphylococcus aureus blood cultures at presentation. Three of our five patients required surgical drainage. Two of these patients had pathologic fracture of the clavicle while receiving treatment and then went on to develop complete resorption of the medial clavicle. Isolated reports of acute staphylococcal osteomyelitis of the clavicle in children occur in the literature. This behaves very differently from chronic sclerosing osteomyelitis and tuberculous osteomyelitis of the clavicle, which are more commonly reported. Our impression is that early treatment with high-dose intravenous antistaphylococcal antibiotics helps avoid the complication of pathologic fracture. The functional result after resorption of the medial clavicle is very good in the short term.
Acute Disease↗