Biomedical subjects

S Jäger

Publications and source records attributed to S Jäger.

77 records · Page 5Linked to original sources

PubMed1979

[Contribution on household dust allergy (author's transl)].

In 1970 the allergy out-patient department of the First Otolaryngological University Hospital of Vienna reported for the first time about the increasing significance of mould fungus allergies in the respiratory tract. RAST now makes in possible to analyze the indivudual fractions of a household dust sensitization by way of experiments. We have seen that in the case of positive RAST reactions to household dust, which is a mixed antigen unspecific as such, evidence can be found for at least one of the antigens "mould fungus", "household dust mite", or "animal hair" in positive RAST categories. Among the 107 cases of the RAST categories 2 und 3 with respect to household dust (h3) a household-dust mite sensitization was evidenced in 88 percent, the respective figures for animal hair sensitization being 49 percent and for mould fungus sensitization 43 percent.

Austria↗

PubMed1977

[Computer documentation of allergological data on patients suffering from allergies of the ENT-tract (author's transl)].

After a brief discussion of the purpose of EDP in medicine an EDP system is described that serves the collection of data on patients of an allergy department. It was taken into account that in addition to data concerning case histories and the general and special status data on the different courses of therapies and test results can be collected. The system is specifically adapted to the problem of allergies of the respiratory tract, but may also be used--with minor additions or alterations--for internal or dermatological cases. The aim of this documentation is the systemization and at the same time the rationalization of the examination course, without, however, ruling out individual extensions. Such a system facilitates and accelerates not only the collection of data, it also allows a faster systematic disclosure of errors and makes a meaningful scientific evaluation possible.

Acute Disease↗

PubMed1976

[Antigen spectrum of allergic rhinitis (author's transl)].

The results of 10.000 individual tests have shown that it is necessary to revise and supplement the influences and the emergence of new antigens support this demand. Refined testing for grass pollen seems to be of particular importance, whereby cross reactions must be taken into account. The test program we must, furthermore, take into consideration the geographical incidence distribution of trees and herbs. In Austria, a considerable amount of ragweed pollen has recently been ascertained to be a cause of pollinosis and asthma. The grain pollens are of great importance and so is household dust, which contains regionally different antigens. Animal hairs and epithelia must be tested if the case history indicates possible involvement of these factors. Special mention is made of the increasing significance of mold spores and bacteria. The variety of listed antigens, each of which may cause allergic rhinitis, shows the importance of supplementing the Hansen test. The new priorities in the test programme are incorporated in, and juxtaposed to the Hansen scheme (see Table 1) for clarification.

Allergens↗

PubMed1976

[Tumour frequency in autopsy cases. V. The leucoses (author's transl)].

The analysis is based on the catalogue of neoplasms notifiable in the German Democratic Republic (ICD-Code Nrs. 140-209, 210.2, 211.3, 211.9, 225, 226.2, 226.3, 253.2, 702, 757.2). At the Medical Academy of Erfurt 22155 autopsies (12212 males, 9943 females) of adults (15 years and upwards) were registered in the period from 1950 to 1966. Among them 322 leucoses (1,5% of autopsies and 4,3% of malignant tumours) were observed. The cases are distributed among 175 males (1,4% of males) and 147 females (1,5% of females). There is no sex difference in frequency. Age and sex distribution are presented for all leucoses and for chronic lymphatic leucosis, chronic myeloic leucosis and acute leucoses.

Adolescent↗

PubMedDate not supplied

Immunotherapy with sublingual birch pollen extract. A short-term double-blind placebo study.

The aim of this double-blind placebo-controlled study was to evaluate the efficacy and tolerability of short-term birch pollen sublingual immunotherapy. Forty-one patients suffering from allergic rhinoconjunctivitis caused by Betula alba were included. Exclusion criteria were the following: undergoing immunotherapy within the last 2 years, contraindications to immunotherapy, pregnancy and nursing. The treatment schedule comprised a 28-day basic course, followed by a 3-month maintenance treatment. The evaluation of the parameters was performed before treatment and 4 months after the last maintenance dose. Skin prick test and conjunctival provocation test (CPT) in a dilution series were carried out to determine the threshold of the reaction. The objective parameters used were the diameter of the skin wheals and the lowest concentration, of the allergen extract to induce the symptoms of itching and reddening of the eyes. The allergic reaction in general was evaluated with the help of a 2-h birch pollen challenge in the Vienna Challenge Chamber (VCC); nasal flow and resistance was measured by rhinomanometry; and nasal secretion was quantified by weighing used handkerchiefs. Bronchial reactions were objectified by spirometry; subjective symptoms of the eyes, the nose and the bronchial tract were documented by the patients via a visual analog scale. Birch pollen specific IgE and IgG were evaluated by monoclonal antibody enzyme immunoassay before (T0) and after (T1) treatment. For statistics p < 0.05 was applied. At T0 there was no decisive difference in the in vitro and in vivo results between the two groups. After the treatment period (T1), actively treated patients showed a significantly higher tolerance to the birch pollen CPT (p < 0.01). The skin reaction was significantly lower than in the placebo group. Furthermore, actively treated patients produced less than half of the nasal secretion of placebo-treated patients during the challenge session. The rhinomanometry analysis during the challenge showed significant differences for verum and placebo in favor of the actively treated patients (p = 0.033). There was no significant difference in the specific IgE and IgG concentrations. The side effects and compliance during the treatment were comparable in both groups. In conclusion, sublingual immunotherapy is a well tolerated and clinically effective method of treatment.

Administration, Sublingual↗