Primary squamous syringometaplasia with no underlying malignancy.
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Biomedical subjects
Publications and source records attributed to S Jerasutus.
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Twenty-nail dystrophy is a distinctive pattern of nail changes, in which all 20 nails are uniformly affected with excessive longitudinal ridging and loss of luster. Because of the rarity of this disorder, and controversy surrounding its cause and pathogenesis, we share our experience with five patients whose clinical diagnoses were consistent with 20-nail dystrophy. Histologically, all patients showed distinctive changes of spongiotic inflammation of the nail matrix. The cause and pathogenesis of these changes are still unknown. We suggest the concept that they represent a subgroup of endogenous eczema with a predilection for the nail matrix. A second, and less likely, hypothesis is that these lesions represent an autoimmunologic response to the nail matrix.
A case of papillary eccrine adenoma was studied by electron microscopy. Dilated ducts that contained granular eosinophilic material, often associated with intraluminal papillary projections were observed. The ductlike structures were composed of basal and luminal cells. Within the luminal cells there were intracytoplasmic cavities, but neither secretory granules nor glandular structure were observed. On the basis of our observations, papillary eccrine adenoma appears to differentiate toward ductal structures of the eccrine sweat apparatus.
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