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Biomedical subjects

S Jhangiani

Publications and source records attributed to S Jhangiani.

4 recordsLinked to original sources
PubMed1987

Pancreatitis in a native American Indian population.

We have studied pancreatitis in a population of Southwestern American Indians where gallstones are frequent, alcohol consumption is presumably high, but where smoking is an uncommon habit. Over a 5-year period, 131 cases of pancreatitis (65 males, 66 females) were observed: 66 (50%) were thought to be biliary pancreatitis, 54 cases (41%) alcoholic pancreatitis, and 5 cases (4%) were caused by injuries. In 6 cases (5%) no definite cause was found. Smoking appeared to be increased in male subjects with alcoholic pancreatitis when compared to subjects with alcoholic liver cirrhosis--a group with similar drinking habits. (Adjusted odds ratio = 12.5, p = 0.008). No such relationship was observed for females. Our findings suggest that in this population smoking may be an additional important risk factor for male subjects with alcoholic pancreatitis.

Alcohol Drinking↗
PubMed1987

Riboflavin metabolism in the hypothyroid human adult.

It had been shown that thyroxine regulates the conversion of riboflavin to riboflavin mononucleotide and flavin adenine dinucleotide (FAD) in laboratory animals. In the hypothyroid rat, the flavin adenine dinucleotide level of the liver decreases to levels observed in riboflavin deficiency. We have shown that in six hypothyroid human adults, the activity of erythrocyte glutathione reductase, an accessible FAD-containing enzyme, is decreased to levels observed during riboflavin deficiency. Thyroxine therapy resulted in normal levels of this enzyme while the subjects were on a controlled dietary regimen. This demonstrates that thyroid hormone regulates the enzymatic conversion of riboflavin to its active coenzyme forms in the human adult.

Aged↗
PubMed1986

Clinical zinc deficiency during long-term total enteral nutrition.

Zinc deficiency during long-term total parenteral nutrition has been well reported in the literature. However, there is limited information available on zinc deficiency occurring during total enteral nutrition. Two cases of clinical zinc deficiency in patients on long-term enteral feedings are presented. Nutritional assessment of these two patients on admission revealed hypoalbuminemic malnutrition. Nutritional support in the form of nasogastric tube feedings were initiated in both patients due to altered mental status. The formula used was Ensure (Ross Labs, Columbus, OH), which provided greater than 150% of the RDA for zinc. However, four months and seven months after initiation of adequate nutritional support, both patients developed skin rashes around the groin and under the breasts and axilla. Serum zinc levels were depressed in both patients, to 42 and 54 mg/dL, respectively (normal for the authors' laboratory, 66 to 120 mg/dL). Supplementation with zinc sulfate 220 mg per day via nasogastric tube resulted in disappearance of the rash with return of serum zinc to normal levels. The authors suggest close observation of patients on long-term enteral nutrition for clinical manifestation of zinc deficiency, especially an unexplained skin rash. Further studies are needed to establish minimum daily zinc requirements in patients on long-term enteral feedings.

Aged↗